Modulating hesperetin bioavailability at the level of its intestinal metabolism and ABC transporter mediated efflux studied in Caco-2 monolayers

Brand, Walter; Wel, Petronella A.I. van der; Williamson, Gary; Bladeren, P.J. van; Rietjens, I.M.C.M.

doi:10.1016/j.cbi.2007.06.006

Cited by 3 publications

(3 citation statements)

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“…It is now clear that many flavonoid conjugates interact with ABC transporters, and that these transporters are crucial for determining their distribution around the body. For example, ABCC2 is situated on the brush border of small intestine enterocytes, and effluxes some conjugates back towards the gut lumen and, in effect, these compounds per se are no longer bioavailable to the body (Brand, van der Wel, Williamson, van Bladeren, & Rietjens, ; Williamson et al., ). ABCG2 also plays an important role in the efflux of flavonoid conjugates from cells (Zhang, Yang, & Morris, ).…”

Section: Interaction Of Flavonoids With the Gastrointestinal Tractmentioning

confidence: 99%

The Bioavailability, Transport, and Bioactivity of Dietary Flavonoids: A Review from a Historical Perspective

Williamson

Kay

Crozier

2018

Comp Rev Food Sci Food Safe

419

288

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Flavonoids are plant-derived dietary components with a substantial impact on human health. Research has expanded massively since it began in the 1930s, and the complex pathways involved in bioavailability of flavonoids in the human body are now well understood. In recent years, it has been appreciated that the gut microbiome plays a major role in flavonoid action, but much progress still needs to be made in this area. Since the first publications on the health effects of flavonoids, their action is understood to protect against various stresses, but the mechanism of action has evolved from the now debunked simple direct antioxidant hypothesis into an understanding of the complex effects on molecular targets and enzymes in specific cell types. This review traces the development of the field over the past 8 decades, and indicates the current state of the art, and how it was reached. Future recommendations based on this historical analysis are (a) to focus on key areas of flavonoid action, (b) to perform human intervention studies focusing on bioavailability and protective effects, and (c) to carry out cellular in vitro experiments using appropriate cells together with the chemical form of the flavonoid found at the site of action; this could be the native form of compounds found in the food for studies on digestion and the intestine, the conjugated metabolites found in the blood after absorption in the small intestine for studies on cells, or the chemical forms found in the blood and tissues after catabolism by the gut microbiota.

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Section: Interaction Of Flavonoids With the Gastrointestinal Tractmentioning

confidence: 99%

The Bioavailability, Transport, and Bioactivity of Dietary Flavonoids: A Review from a Historical Perspective

Williamson

Kay

Crozier

2018

Comp Rev Food Sci Food Safe

419

288

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“…52 Many flavonoid adducts have been well studied for their interactions with ATP-binding cassette transporter proteins, which are critical in determining their distribution in vivo. 53 Metabolism and transport back to the lumen from the enterocyte via the ATP-binding cassette transporter is thought to limit the bioavailability of flavonoids.…”

Section: Bioavailability Of Flavonoid Compoundsmentioning

confidence: 99%

“…It has been shown that genistein can interact with the family of transporter proteins (OATP1B1), and further studies have shown that the flavonoids mangiferin and silymarin interact with human OAT1, whereas quercetin, naringenin, and naringenin‐7‐ O ‐rutinoside (Narirutin) do not 52 . Many flavonoid adducts have been well studied for their interactions with ATP‐binding cassette transporter proteins, which are critical in determining their distribution in vivo 53 . Metabolism and transport back to the lumen from the enterocyte via the ATP‐binding cassette transporter is thought to limit the bioavailability of flavonoids.…”

Section: Bioavailability Of Flavonoid Compoundsmentioning

confidence: 99%

Flavonoids and intestinal microbes interact to alleviate depression

et al. 2021

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Flavonoids have a variety of biological activities that are beneficial to human health. However, owing to low bioavailability, most flavonoids exert beneficial effects in the intestine through metabolism by the flora into a variety of structurally different derivatives. Also, flavonoids can modulate the type and structure of intestinal microorganisms to improve human health. It has been reported that the development of depression is accompanied by changes in the type and number of intestinal microorganisms, and gut microbes can significantly improve depressive symptoms through the gut-brain axis. Therefore, the interaction between flavonoids and intestinal microbes to alleviate depression is discussed.

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Dietary Flavonoids

Williamson

2012

Present Knowledge in Nutrition

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Modulating hesperetin bioavailability at the level of its intestinal metabolism and ABC transporter mediated efflux studied in Caco-2 monolayers

Cited by 3 publications

References 0 publications

The Bioavailability, Transport, and Bioactivity of Dietary Flavonoids: A Review from a Historical Perspective

The Bioavailability, Transport, and Bioactivity of Dietary Flavonoids: A Review from a Historical Perspective

Flavonoids and intestinal microbes interact to alleviate depression

Dietary Flavonoids

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