Modulating hesperetin bioavailability at the level of its intestinal metabolism and ABC transporter mediated efflux studied in Caco-2 monolayers

Brand, Walter; Wel, Petronella A.I. van der; Williamson, Gary; Bladeren, P.J. van; Rietjens, Ivonne M.C.M.

doi:10.1016/j.toxlet.2007.05.276

Cited by 2 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…52 Many flavonoid adducts have been well studied for their interactions with ATP-binding cassette transporter proteins, which are critical in determining their distribution in vivo. 53 Metabolism and transport back to the lumen from the enterocyte via the ATP-binding cassette transporter is thought to limit the bioavailability of flavonoids.…”

Section: Bioavailability Of Flavonoid Compoundsmentioning

confidence: 99%

“…It has been shown that genistein can interact with the family of transporter proteins (OATP1B1), and further studies have shown that the flavonoids mangiferin and silymarin interact with human OAT1, whereas quercetin, naringenin, and naringenin‐7‐ O ‐rutinoside (Narirutin) do not 52 . Many flavonoid adducts have been well studied for their interactions with ATP‐binding cassette transporter proteins, which are critical in determining their distribution in vivo 53 . Metabolism and transport back to the lumen from the enterocyte via the ATP‐binding cassette transporter is thought to limit the bioavailability of flavonoids.…”

Section: Bioavailability Of Flavonoid Compoundsmentioning

confidence: 99%

See 1 more Smart Citation

Flavonoids and intestinal microbes interact to alleviate depression

et al. 2021

View full text Add to dashboard Cite

Flavonoids have a variety of biological activities that are beneficial to human health. However, owing to low bioavailability, most flavonoids exert beneficial effects in the intestine through metabolism by the flora into a variety of structurally different derivatives. Also, flavonoids can modulate the type and structure of intestinal microorganisms to improve human health. It has been reported that the development of depression is accompanied by changes in the type and number of intestinal microorganisms, and gut microbes can significantly improve depressive symptoms through the gut-brain axis. Therefore, the interaction between flavonoids and intestinal microbes to alleviate depression is discussed.

show abstract

Section: Bioavailability Of Flavonoid Compoundsmentioning

confidence: 99%

Section: Bioavailability Of Flavonoid Compoundsmentioning

confidence: 99%