Modulating Effects of Thyme and Its Major Ingredients on Oxidative DNA Damage in Human Lymphocytes

Aydın, Sevtap; Başaran, Ahmet; Başaran, Nurşen

doi:10.1021/jf0402375

Cited by 76 publications

(53 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Similarly, "Oregpig" (commercial feed additive containing 60 g carvacrol and 55 g thymol per kilogram) had non-specific immunostimulatory effects on porcine immune cells, and the proportion of CD4, CD8, MHC class II antigen, and non-T/non-B cells in peripheral blood lymphocytes was significantly higher in the Oregpigreceiving pigs than in the control animals (Walter and Bilkei 2004). On the other hand, Aydin et al (2005) showed in their in vitro study that high concentrations of carvacrol, thymol and γ-terpinene are able to induce lymphocytes DNA damage. This fact could Table 3.…”

Section: Discussionmentioning

confidence: 99%

Anti-Inflammatory Effects of Thyme Essential Oil in Mice

Juhás¹,

Bujňáková²,

Rehák³

et al. 2008

Acta Vet. Brno

View full text Add to dashboard Cite

Juhás Š., D. Bujňáková, P. Rehák, Š. Čikoš, S. Czikková, J. Veselá, G. Iľková, J. Koppel: Anti-Inflammatory Effects of Thyme Essential Oil in Mice. Acta Vet. Brno 2008, 77: 327-334. Plant essential oils are plant secondary metabolites possessing various pharmacological properties, primarily anti-oxidative, antimicrobial or immunomodulatory ones. The aim of this work was to study the effects of thyme essential oil dietary administration in murine DTH/ CHS reaction, carrageenan paw oedema and TNBS colitis. Thyme essential oil was added to the murine diet at three concentrations (5000, 2500 and 1250 ppm) and fed to Balb/c mice. The extent of ear swelling in DTH/CHS reaction and paw oedema induced by carrageenan application was measured using the Mitutoyo thickness gauge. In the model of TNBS colitis we evaluated the changes in body weight, the colon weight : body weight ratio, bacterial translocation to mesenteric lymph nodes, and macroscopical and histological scores. IL-1 and IL-6 messenger RNA expression in colonic samples of one experimental group were assessed using quantitative real-time reverse transcriptase PCR. Dietary supplementation with 5000 ppm of thyme essential oil significantly decreased paw oedema and ear swelling. This thyme essential oil concentration caused a significant inhibition of total mRNA IL-1 expression in the mouse colon, and markedly decreased the macroscopic and microscopic scores of colitis. On the other hand, the 1250 ppm of thyme essential oil in diet increased ear oedema induced by oxazolone application in mice. Our study indicates that thyme essential oil is able to affect murine experimental inflammatory models depending on the concentration used. It is concluded that the anti-inflammatory effects of thyme essential oil should be interpreted with a caution due to its contradictory, dose-related effects.

show abstract

Section: Discussionmentioning

confidence: 99%

Anti-Inflammatory Effects of Thyme Essential Oil in Mice

Juhás¹,

Bujňáková²,

Rehák³

et al. 2008

Acta Vet. Brno

View full text Add to dashboard Cite

show abstract

“…The anti-mutagenic property of lavender oil makes it a promising candidate for new applications in human healthcare. By using the comet assay technique Aydin et al [58] tested the modulating effects of thyme and its major components against the oxidative DNA damage induced in human lymphocytes by hydrogen peroxide (H 2 O 2 ). The same group of authors investigated the influence of thyme against the heterocyclic amine 2-amino-3-methylimidazo[4,5-f]-quinoline (IQ) and mitomycin C [59].…”

Section: Mutagenicity Anti-mutagenicity and Dna-protective Effectsmentioning

confidence: 99%

Cytotoxic, anti-carcinogenic and antioxidant properties of the most frequent plant volatiles

Slameñová¹,

Horváthová²

2013

neo

View full text Add to dashboard Cite

Flowers, berries, leaves, barks and roots of different plants have been used through the ages as a source of flavor in food and perfume preparations. The volatiles responsible for the flavor of botanicals can be extracted from the plant material as "essential oils" (EOs), called also volatile oils or ethereal oils. The term essential is intended to indicate that the oil is the fragrant essence of the plant from which it is extracted. EOs are constituted by hydrocarbons (monoterpenes and sesquiterpenes) and oxygenated compounds (alcohols, esters, ethers, aldehydes, ketones, lactones, phenols and phenol ethers). Of the numerous groups of naturally occurring compounds examined so far terpenes are known as fragrances and flavoring agents. The data reported in this review including the data obtained in our laboratory show that many of EOs exhibit a range of biological activities inclusive of antioxidative, anti-mutagenic and anti-carcinogenic activities. Most of them belong to phytochemicals with chemopreventive potential. On the other hand some herbal products can cause serious adverse effects. A complex research of toxic, genotoxic, anti-mutagenic and anti-carcinogenic effects of EOs is therefore very important.

show abstract

“…In human lymphocytes, carvacrol induced DNA damage at concentrations >0.05 mM, and thymol induced DNA damage at higher concentrations (0.2 mM). Below the DNA damaging concentrations, carvacrol, and thymol may protect against DNA-damage-induced by mitomycin C and 2-amino-3-methylimidazo [4,5-f]-quinoline [27,28]. Similarly, carvacrol and thymol have been reported to reduce the number of DNA lesions induced by H 2 O 2 in human hepatoma HepG2 and colonic Caco-2 cells [29].…”

Section: Resultsmentioning

confidence: 99%

Evaluation of the Genotoxicity of Essential Oil From Origanum Compactum Benth. In Human Lymphocytes

Sbayou

Talbi

Talha

et al. 2016

Asian J Pharm Clin Res

View full text Add to dashboard Cite

Objective: Essential oils with antimicrobial and antioxidant activities have gained importance. This study was conducted to investigate the genotoxic potential of the essential oil of Origanum compactum.Methods: Micronucleus test and proliferation index (PI) were used to evaluate the genotoxic effect of the essential oil of O. compactum on human lymphocytes. Results:The results demonstrated that the PI values were influenced by the tested essential oil. An increase in concentration of essential oil also caused the appearance of micronuclei. Conclusion:The results of the present work suggest that O. compactum essential oil exhibited genotoxic activity at higher concentration. Further studies are necessary to confirm these findings.

show abstract

Modulating Effects of Thyme and Its Major Ingredients on Oxidative DNA Damage in Human Lymphocytes

Cited by 76 publications

References 35 publications

Anti-Inflammatory Effects of Thyme Essential Oil in Mice

Anti-Inflammatory Effects of Thyme Essential Oil in Mice

Cytotoxic, anti-carcinogenic and antioxidant properties of the most frequent plant volatiles

Evaluation of the Genotoxicity of Essential Oil From Origanum Compactum Benth. In Human Lymphocytes

Contact Info

Product

Resources

About