Modulating effects of prenatal stress on hyperthermia induced in adult rat offspring by restraint or LPS-induced stress

Hashimoto, Makoto; Watanabe, Tatsuo; Fujioka, Takashi; Tan, Nobusuke; Yamashita, Hiroshi; Nakamura, Shôji

doi:10.1016/s0031-9384(01)00473-5

Cited by 44 publications

(36 citation statements)

References 28 publications

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“…These models include repeated stimulation of maternal rats to confrontation (25), acute immobilization (26), bright light (27,28), and loud noise (29,30). These studies have shown a decrease in total peripheral leukocyte count (26,31) and decreases in the peripheral CD4ϩ and CD8ϩ T-cell subsets in older rats (31).…”

Section: Discussionmentioning

confidence: 99%

Intrauterine Growth Restriction Alters T-Lymphocyte Cell Number and Dual Specificity Phosphatase 1 Levels in the Thymus of Newborn and Juvenile Rats

Contreras

Hale

et al. 2011

Pediatr Res

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Intrauterine growth restricted (IUGR) infants have increased susceptibility to infection associated with higher risk of illness and death. Dual specificity phosphatase 1 (DUSP1), which is transcribed in the thymus, increases in quantity as T cells mature and differentiate into CD4ϩ cells. Little is known about how IUGR affects DUSP1 levels and T-cell subpopulations over time. We hypothesized that IUGR would decrease cell count, CD4ϩ and CD8ϩ subpopulations of T lymphocytes, and DUSP1 levels in IUGR rat thymus and spleen. Bilateral uterine artery ligation produced IUGR rats. Thymus and spleen were harvested at P0 and P21. Flow cytometry was used to compare CD4ϩ and CD8ϩ lymphocyte populations. Real-time RT-PCR and Western blotting were used to determine DUSP1 quantity. IUGR significantly decreased total cell count in P0 and P21 IUGR male and female thymus. IUGR significantly increased CD4ϩ cells in IUGR P0 males and females, significantly decreased CD4ϩ cells in P21 female thymus, and significantly altered DUSP1 levels in the IUGR female thymus at P0 and P21, although it is not yet known whether the change in DUSP1 levels is due to a change in the level per cell or to a change in cellular composition of the thymus. (Pediatr Res 70: 123-129, 2011)

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Section: Discussionmentioning

confidence: 99%

Intrauterine Growth Restriction Alters T-Lymphocyte Cell Number and Dual Specificity Phosphatase 1 Levels in the Thymus of Newborn and Juvenile Rats

Contreras

Hale

et al. 2011

Pediatr Res

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“…In vitro, IFN-g release from T-cells was increased (Vanbesien-Mailliot et al, 2007) and LPS induced-TNF-a production was decreased (Couret et al, 2009), while in vivo spleen and brain frontal cortex levels of IL-1b were increased by prenatal stress (Laviola et al, 2004; but see also Kohman et al, 2008). Prenatal stress also increases febrile response to LPS administration in rats (Hashimoto et al, 2001) and increased vulnerability toward airway hyper-responsiveness and inflammation in a rat model of asthma (Pincus-Knackstedt et al, 2006). Antibody responses to keyhole limpet hemocyanin were increased (Klein & Rager, 1995), while antibody titers to herpes simplex virus type 1 and Arthus skin reaction to old tuberculin were suppressed by prenatal stress (Sobrian et al, 1997).…”

Section: Animal Studiesmentioning

confidence: 96%

Early adversity, immunity and infectious disease

Avitsur

Levy

Goren

et al. 2015

Stress

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Complex interactions between biological, behavioral and environmental factors are involved in mediating individual differences in health and disease. In this review, we present evidence suggesting that increased vulnerability to infectious disease may be at least, in part, due to long-lasting effects of early life psychosocial adversities. Studies have shown that maternal psychosocial stress during pregnancy is associated with long lasting changes in immune function and disease resistance in the offspring. Studies further indicated that harsh environmental conditions during the neonatal period may also cause lasting changes in host response to infectious disease. Although the mechanisms involved in these effects have not been fully examined, several potential mediators have been described, including changes in the development of the offspring hypothalamic-pituitary-adrenal axis, alterations in epigenetic pathways, stress-related maternal health risk behavior and infection during pregnancy. Although there are ample literature indicating that perinatal psychosocial stress increases vulnerability to disease, other reports suggest that mild predictable stressors may benefit the organism and allow better coping with future stressors. Thus, understanding the possible consequences of perinatal adversities and the mechanisms that are involved in immune regulation is important for increasing awareness to the potential outcomes of early negative life events and providing insight into potential therapies to combat infection in vulnerable individuals.

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“…The restraint stress paradigm used in this study was originally selected because it was expected to produce the most extreme effects (Fujioka et al, 1999;Hashimoto et al, 2001). The most common paradigm of restraint stress is three 45-min sessions daily Prenatally stressed (PS) and artificially reared (AR) male rats were significantly more active than prenatally stressed mother-reared male rats.…”

Section: Effects Of Prenatal and Postnatal Manipulationsmentioning

confidence: 99%

Early adversity alters attention and locomotion in adult Sprague-Dawley rats.

Burton¹,

Lovic²,

Fleming³

2006

Behavioral Neuroscience

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This study investigated the effects of prenatal stress and its interaction with artificial rearing (AR) on adult rat behavior. Pregnant dams underwent restraint stress from Gestational Day 10 to 21. After parturition, pups were raised by their mothers or in the AR paradigm, with or without stroking stimulation. In adulthood, rats were tested on prepulse inhibition (PPI), locomotor activity, elevated plus-maze, and spatial working memory. There were main effects and interactions of both prenatal stress and AR on activity. Additional stimulation reduced activity in nonstressed AR rats but increased activity in prenatally stressed AR rats. AR altered PPI and plus-maze behavior whereas additional stimulation partially reversed these effects. This study demonstrates that prenatal experiences can modulate the effects of postnatal treatments.

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Modulating effects of prenatal stress on hyperthermia induced in adult rat offspring by restraint or LPS-induced stress

Cited by 44 publications

References 28 publications

Intrauterine Growth Restriction Alters T-Lymphocyte Cell Number and Dual Specificity Phosphatase 1 Levels in the Thymus of Newborn and Juvenile Rats

Intrauterine Growth Restriction Alters T-Lymphocyte Cell Number and Dual Specificity Phosphatase 1 Levels in the Thymus of Newborn and Juvenile Rats

Early adversity, immunity and infectious disease

Early adversity alters attention and locomotion in adult Sprague-Dawley rats.

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