Modulating effects of acepromazine on the reactive oxygen species production by stimulated equine neutrophils

Sandersen, Charlotte; Mouithys‐Mickalad, Ange; Rebière, Geoffroy de la; Deby, Ginette; Serteyn, Didier; Franck, Thierry

doi:10.1111/j.1467-2995.2010.00583.x

Cited by 6 publications

(3 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…When the effect of acepromazine on the production of reactive oxygen species (ROS) was evaluated in vitro using equine neutrophils, ROS production was reduced in a dose‐dependent manner (Sandersen et al. ). In another study, administration of acepromazine or promethazine to horses resulted in a significant decrease in ROS production in activated neutrophils ex vivo compared to untreated horses (Péters et al.…”

Section: Immunomodulation By Injectable Sedative and Anesthetic Agentsmentioning

confidence: 99%

The immune response to anesthesia: Part 2 sedatives, opioids, and injectable anesthetic agents

Anderson

Duke‐Novakovski

Singh

2014

Veterinary Anaesthesia and Analgesia

View full text Add to dashboard Cite

Section: Immunomodulation By Injectable Sedative and Anesthetic Agentsmentioning

confidence: 99%

The immune response to anesthesia: Part 2 sedatives, opioids, and injectable anesthetic agents

Anderson

Duke‐Novakovski

Singh

2014

Veterinary Anaesthesia and Analgesia

View full text Add to dashboard Cite

“…Additionally, it has been shown in vitro that ACP reduces the tumor necrosis factor-a production of monocytes [13], inhibits the differentiation of monocytes into macrophages [14], and, decreases the production of reactive oxygen species or its by-products [15][16][17][18]; PTZ also can produce the latter effect.…”

Section: Introductionmentioning

confidence: 99%

Comparison of the Sedative and Hemodynamic Effects of Acepromazine and Promethazine in the Standing Horse

Pequito

Amory

Serteyn

et al. 2012

Journal of Equine Veterinary Science

Self Cite

View full text Add to dashboard Cite

“…Isoflurane has been also proposed to reduce the activity of this enzyme [48]. Acepromazine has anti-inflammatory properties and modulates polymorphonuclear activation and reactive oxygen species production in horses [49][50][51]. Benzodiazepines inhibit phagocyte oxidative metabolism and production of TNF-α and IL-6 [52].…”

Section: Discussionmentioning

confidence: 99%

Effect of High Pressure-Volume and Low Pressure-Volume Mechanical Ventilation on Plasma Concentrations of Inflammatory Markers in Horses during General Anaesthesia

Cenani¹,

Cerri

Àlex

et al. 2014

J Anesth Clin Res

View full text Add to dashboard Cite

Systemic changes of interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), neutrophil elastase (ELT) and myeloperoxidase (MPO) during mechanical ventilation (MV) in horses anaesthetized for surgery are evaluated. Thirty-four client-owned ASA I-II horses randomly received mechanical ventilation (MV) with either a peak inspiratory pressure (PIP) of 30 cm H 2 O and tidal volume (VT)>10 mL kg-1 (high pressure-volume MV) or PIP of 15 cm H 2 O and VT ≤ 10 mL kg-1 (low pressure-volume MV) in dorsal or lateral recumbency. Horses were premedicated with acepromazine (0.1 mg kg-1 IM) and xylazine (0.6 mg kg-1 IV), induced with midazolam (0.06 mg kg-1 IV) and ketamine (2.2 mg kg-1 IV) and maintained with isoflurane in oxygen 70% plus ketamine-midazolam infusion (1 and 0.02 mg kg-1 h-1 , respectively). Anti-inflammatory drug and antibiotics were administered before surgery. Plasmatic proinflammatory mediator concentrations were estimated by ELISA at the beginning (T 0) and after 60 minutes (T 1) of MV. Mean plasmatic TNF-α, MPO, and ELT concentrations at T 1 were significantly (p<0.05) lower than T 0. Mean plasmatic concentration of IL-6 did not significantly change with time. The reduction in plasmatic concentration of proinflammatory mediators at T 1 was not linked to ventilation strategy or recumbency. None of the ventilation protocols enhanced systemic inflammatory response during surgery after 1 hour of MV. The anti-inflammatory properties of drugs included in the anaesthesia protocol may have contributed to the overall decreased systemic inflammatory mediator concentrations, despite MV and surgery. J o u rn al of A n e s th es ia & C li n ic a l Resea rc h

show abstract

Modulating effects of acepromazine on the reactive oxygen species production by stimulated equine neutrophils

Abstract: These findings may have a therapeutic relevance when phenothiazines are used in horses suffering from inflammatory diseases in which neutrophil activation and ROS production are implicated.

Cited by 6 publications

References 43 publications

The immune response to anesthesia: Part 2 sedatives, opioids, and injectable anesthetic agents

The immune response to anesthesia: Part 2 sedatives, opioids, and injectable anesthetic agents

Comparison of the Sedative and Hemodynamic Effects of Acepromazine and Promethazine in the Standing Horse

Effect of High Pressure-Volume and Low Pressure-Volume Mechanical Ventilation on Plasma Concentrations of Inflammatory Markers in Horses during General Anaesthesia

Contact Info

Product

Resources

About