Modulating effect of selected pharmaceuticals on bone in female rats exposed to 2,3,7,8-tetrachlorodibenzo-<i>p</i>-dioxin (TCDD)

Pezowicz, Celina; Tomanik, Magdalena; Kuropka, Piotr; Dudek, Krzysztof; Fita, Katarzyna; Styczyńska, Marzena; Wiglusz, Rafał J.

doi:10.1039/c8ra03619e

Cited by 6 publications

(12 citation statements)

References 29 publications

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“…The previous reports confirm the need to search for substances that eliminate or reduce the effects of dioxins on the bone tissue [ 4 , 19 , 48 , 50 ].…”

Section: Discussionmentioning

confidence: 53%

“…Previous experimental studies have proven the adverse effects of dioxins as environmental factors on bone remodeling in the experimental animals, both in developmental and adult age [ 43 ]. It was found that exposure to TCDD led to decrease of bone mechanical strength and caused an increase in density of cortical bone in studied adult rats [ 4 , 19 , 47 , 48 , 49 ].…”

Section: Discussionmentioning

confidence: 99%

“…The best-known substance that represents this group is TCDD, which is classified as one of the most potent toxins. The molecular activity of dioxins is based on constant activation of the aryl hydrocarbon receptor (AhR), which, for example, induces the transcription of genes of different molecular forms of cytochrome P-450 (CYP), an enzyme responsible for metabolism of xenobiotics [ 4 , 5 , 6 ]. The exposure of organisms to dioxins causes numerous multi-organ disorders, for example, cancer progression, chloracne, liver enzymes overproduction, metabolism disruption, diabetes, reproductive disorders, thyroid function disorders, cardiovascular diseases, and also abnormalities of bone tissue, disrupting its microarchitecture and mechanical properties [ 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

“…That can result in formation of hard tissues with low mineral levels [ 17 , 18 ]. The bones of the cranial vault and long bones differ in their histological structure, which is associated with their slightly various functions [ 4 , 19 , 20 , 21 , 22 ]. The intensity of bone metabolic processes is associated with the availability of transmission of signals—and therefore, with blood flow [ 23 ].…”

Section: Introductionmentioning

confidence: 99%

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The Protective Effect of Xanthohumol on the Content of Selected Elements in the Bone Tissue for Exposed Japanese Quails to TCDD

Całkosińska

Dominiak

Sobolewska

et al. 2020

IJERPH

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Dioxins (including 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) are highly toxic and persistent chemicals widely distributed in the environment in trace amounts, and are side products of industrial and chemical processes. Exposure to dioxins leads to multiorgan morphological and functional abnormalities, including within the bone tissue, disrupting its microarchitecture and mechanical properties. Xanthohumol (XN) is a chemical compound classified as a prenylated flavonoid, distinguished by multidirectional biological action. The aim of the study is to assess whether xanthohumol, as a substance with strong antioxidant and anti-inflammatory properties, has the ability to eliminate the negative effects of TCDD on bone tissue. The experiment was conducted on adult Japanese quails. Two different doses of TCDD and xanthohumol were administered to birds. After euthanasia of animals, the research material in the form of cranial vault and hind limb bone was collected, and their mineral compositions of calcium, phosphorus, magnesium, zinc, and iron concentrations were determined using atomic emission spectrometry in an acetylene-air flame method. Our results indicate that the administration of TCDD at a low dose causes more dynamic changes in the concentration of elements in bone, in comparison to a higher dose of dioxin. Results show also that higher doses of the XN cause the linear increase in the concentration of phosphorus and iron in the bone of the hind limb, and calcium in the bones of the cranial vault. In conclusion, our experiment shows that the use of TCDD and XN in Japanese quails together in various doses influences the content of phosphorus, magnesium, zinc, and iron in the research material.

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“…The previous reports confirm the need to search for substances that eliminate or reduce the effects of dioxins on the bone tissue [ 4 , 19 , 48 , 50 ].…”

Section: Discussionmentioning

confidence: 53%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The Protective Effect of Xanthohumol on the Content of Selected Elements in the Bone Tissue for Exposed Japanese Quails to TCDD

Całkosińska

Dominiak

Sobolewska

et al. 2020

IJERPH

Self Cite

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“…73 Moreover, abnormalities in bone mineralization and lower concentrations of calcium and magnesium as well as disorders of the teeth development were observed in newborns from mothers exposed to dioxins. 31,74 Dioxins pass to the fetus through the placenta resulting in disorders of organogenesis including skeletal system and stomatognathic apparatus. 75,76 As an example of the impact of dioxin accumulation on the development of cleft palate, two cases can be described briefly.…”

Section: Dioxin Accumulation and Its Impact On Orofacial Clefts Develmentioning

confidence: 99%

Can contamination of the environment by dioxins cause craniofacial defects?

et al. 2019

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Cleft lip and cleft palate also known as orofacial cleft is a congenital malformation involving the partial or total lack of anatomical continuity of craniofacial tissue. The most common environmental factors that may cause orofacial clefts include pharmaceuticals, alcohol, addictive drugs, and tobacco smoke. Living in the area of industrial factories, garbage, ironworks, crematoria, wastewater treatment plants, and plastic waste landfills also has a significant impact on the development of the craniofacial defects. Some of the main factors causing the formation of congenital craniofacial defects are dioxins, of which emission to the environment is an important environmental and health problem. Dioxins are a diverse group of organic chemical compounds, derivatives of oxanthrene and fumarates, which are organoleptically imperceptible. Acting mainly through induction of inflammation, they influence a number of metabolic processes, including the process of bone mineralization and embryonic development. In this work, we highlight the problem of orofacial cleft including the impact of dioxin on development of this defect and the recommended prevention.

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The influence of a standardized experimental environment on early diagenetic changes to animal bone

Lacel¹,

Wojtków

Tomanik

et al. 2021

Geoarchaeology

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We evaluated the dynamics of the diagenetic changes to pig bones incubated for 4, 10, and 31 months in a controlled environment (soil type, moisture and pH, air humidity, and temperature). The criteria for the assessment were as follows: physical parameters (bone weight), biomechanical parameters (compressive strength), bone microstructure (using micro‐computed tomography), and phosphorus and calcium content in the surrounding soil. It was shown that the bone weight decreased the most after 4 months of incubation, whereas the biggest change in the compressive strength was not observed until after 31 months of incubation. Also, the main changes to the bone microstructure were observed in the initial period of degeneration. After 4 months of the experiment, a major drop in the percentage of the thinnest bone trabeculae was noted, whereas a reverse trend was observed for the thickest trabeculae. Moreover, the most significant decrease in the Ca/P ratio in the surrounding soil was observed after the experiment's first 4 months. We conclude that the bioerosion of collagen observed after the initial experimental period was followed by hydroxyapatite chemical decomposition. These results indicate the usefulness of the applied analyses and the feasibility of ensuring a standardized environment for diagenetic research.

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Modulating effect of selected pharmaceuticals on bone in female rats exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)

Abstract: This paper discusses the problems regarding the influence of TCDD on the mechanical properties and structure of the bone tissue in female rats treated with the dioxin.

Cited by 6 publications

References 29 publications

The Protective Effect of Xanthohumol on the Content of Selected Elements in the Bone Tissue for Exposed Japanese Quails to TCDD

The Protective Effect of Xanthohumol on the Content of Selected Elements in the Bone Tissue for Exposed Japanese Quails to TCDD

Can contamination of the environment by dioxins cause craniofacial defects?

The influence of a standardized experimental environment on early diagenetic changes to animal bone

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