Modulating effect of calcium on the cold defense response formation in normotensive and hypertensive rats

Tkachenko, E. Ya.; Lomakina, S. V.; Козырева, Т. В.

doi:10.1016/j.jtherbio.2005.06.002

Cited by 9 publications

(1 citation statement)

References 14 publications

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“…In our previous experiments, administration of agents blocking calcium channels and those blocking a1-adrenoreceptors (calcium is a secondary messenger of these receptors) leads to shivering suppression, while administration of Ca(2C) ions vice versa promotes earlier initiation of shivering and its enhancement. 30,31 There are also data regarding the influence of a1-adrenoreceptors on ATP release and Na-K ATPase activity. 32,33 The participation of SERCA1, one of the enzymes of the sarcoplasmic reticulum of muscle cells, involved in heat production, may be also suggested.…”

Section: Discussionmentioning

confidence: 99%

Effect of the sympathetic nervous system co-transmitters ATP and norepinephrine on thermoregulatory response to cooling

2015

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The existence of co-transmitters of the sympathetic nervous system norepinephrine (NE) and ATP implies variations in the neuromodulator mechanisms of physiological processes. The role of ATP, as a transmitter of the peripheral part of sympathetic nervous system in the formation of thermoregulatory response is not clear. Whether ATP modulates any parameters of thermoregulatory response to cold; if yes, whether co-transmitters of sympathetic nervous system ATP and NE differently modulate thermoregulatory response and on which parameters of cold-defense response the influence of ATP is more pronounced. Experiments were carried out on rats. ATP (10−6), NE (10−3), and their mixture introduced iontophoretically into skin. Their effects on thermoregulatory parameters (temperature parameters, total oxygen consumption, carbon dioxide release, muscle activity, respiratory coefficient) were studied in thermoneutral conditions (without cold load) and under the cooling. In thermoneutral conditions both ATP and NE enhance total metabolism through increase in metabolic rate of lipids, NE effect being more expressed. It was shown that ATP and NE influence predominantly on the different components of the metabolic response to cold. ATP affects to the greatest extent on cold muscular thermogenesis by increasing shivering almost twofold and lowering its initiation temperature thresholds, whereas NE mainly promotes increase in non-shivering thermogenesis. When introducing the mixture of these biological substances the effect of NE is more expressed and the ATP effect is weakened. The obtained results allow to suggest that in vivo the NE effects can be more expressed when the sympathetic nervous system is stimulated by cold. Thus, NE and ATP being co-transmitters and predominantly acting on the different processes of cold thermogenesis (ATP on shivering and NE on non-shivering) may organize the certain sequence of cold defense responses.

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Section: Discussionmentioning

confidence: 99%

Effect of the sympathetic nervous system co-transmitters ATP and norepinephrine on thermoregulatory response to cooling

2015

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Development of Research on the Thermoregulatory System in Russia

Козырева

2022

Thermal Physiology

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Modulating Effects of Calcium on Immune Response of Homoiothermal Animal under Thermoneutral Conditions and during Deep Cooling

2009

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Preliminary ionophoretic administration of Ca(2+) ions into the skin prevents the inhibitory effects of deep cooling on some processes characterizing the immune response. Differently directed changes in some immune response parameters induced by exogenous calcium and deep cooling suggest that competitive interactions between calcium-dependent processes can serve as mechanisms of functional changes in various physiological systems during the formation of the systemic reaction of a homoiothermal organism to cold.

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Modulating effect of calcium on the cold defense response formation in normotensive and hypertensive rats

Cited by 9 publications

References 14 publications

Effect of the sympathetic nervous system co-transmitters ATP and norepinephrine on thermoregulatory response to cooling

Effect of the sympathetic nervous system co-transmitters ATP and norepinephrine on thermoregulatory response to cooling

Development of Research on the Thermoregulatory System in Russia

Modulating Effects of Calcium on Immune Response of Homoiothermal Animal under Thermoneutral Conditions and during Deep Cooling

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