Modulating DNA damage response in uveal melanoma through embryonic stem cell microenvironment
Yingxu Zhang,
Jinbiao Zheng,
Minyu Chen
et al.
Abstract:Background
Uveal melanoma (UVM) is the most common primary intraocular tumor in adults, with a median survival of 4–5 months following metastasis. DNA damage response (DDR) upregulation in UVM, which could be linked to its frequent activation of the PI3K/AKT pathway, contributes to its treatment resistance. We have reported that embryonic stem cell microenvironments (ESCMe) can revert cancer cells to less aggressive states through downregulation of the PI3K signaling, showing promise in modulat… Show more
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