Modulated release from liposomes entrapped in chitosan/gelatin hydrogels

Ciobanu, Bogdan; Cadinoiu, Anca Niculina; Popa, Marcel; Desbrières, Jacques; Peptu, Cătălina Anişoara

doi:10.1016/j.msec.2014.07.036

Cited by 58 publications

(36 citation statements)

References 30 publications

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“…Liposomes, the most extensively studied and understood pharmaceutical nanocarriers, have been mostly encapsulated into CS hydrogels . Liposomes are safe vehicles, with the capability of encapsulating a wide range of hydrophilic or hydrophobic drugs, having good biocompatibility, low toxicity and lack of immune system activation and allowing targeted delivery of drugs to desired biological sites .…”

Section: Nanoparticle–hydrogel Compositesmentioning

confidence: 99%

“…Since 2002, many researchers have focused on the development of liposome–CS hydrogel systems with a tunable drug release rate according to the physicochemical properties of liposomes and hydrogels. Among the liposome attributes that can affect the release kinetics, liposomal composition, vesicle size and surface charge have been studied for the control of drug delivery over long periods of time. Hydrogel crosslinking density (i.e.…”

Section: Nanoparticle–hydrogel Compositesmentioning

confidence: 99%

“…Hydrogel crosslinking density (i.e. swelling) is also an investigated parameter which affects liposome release . Other nanocarriers, such as microemulsions (MEs), were embedded into a CS matrix for the sustained release of drugs.…”

Section: Nanoparticle–hydrogel Compositesmentioning

confidence: 99%

“…This interesting drug model permits better understanding of calcein release from complex systems. The in vitro release profile of calcein after loading into two types of liposomes (multilamellar vesicles (MLVs), diameter ca 1.2 µm; and small unilamellar vesicles (SUVs), diameter ca 0.112 µm) dispersed in hydrogels with different types of crosslinking was studied . The authors demonstrated that intact liposomes are released from hydrogel matrix even after three weeks, especially MLVs composed of multiple lipid layers.…”

Section: Nanoparticle–hydrogel Compositesmentioning

confidence: 99%

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Chitosan‐based hydrogels: recent design concepts to tailor properties and functions

Racine

Texier

Auzély‐Velty

2017

Polymer International

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Chitosan (CS) has received much attention as a functional biopolymer for designing various hydrogels for biomedical applications. This review provides an overview of the different types of CS-based hydrogels, the approaches that can be used to fabricate hydrogel matrices with specific features and their applications in controlled drug delivery and tissue engineering. Emphasis is laid on the recent design concepts of hybrid hydrogels based on mixtures of CS and natural or synthetic polymers, interpenetrating polymer networks as well as composite hydrogels prepared by embedding nanoparticles into CS matrices.

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Section: Nanoparticle–hydrogel Compositesmentioning

confidence: 99%

Section: Nanoparticle–hydrogel Compositesmentioning

confidence: 99%

Section: Nanoparticle–hydrogel Compositesmentioning

confidence: 99%

Section: Nanoparticle–hydrogel Compositesmentioning

confidence: 99%

See 2 more Smart Citations

Chitosan‐based hydrogels: recent design concepts to tailor properties and functions

Racine

Texier

Auzély‐Velty

2017

Polymer International

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“…In another study, liposomes prepared from phosphatidylcholine (PC) or distearoylglycero-PC and cholesterol (DSPC/Chol), and incorporating calcein or greseofulvin were formulated by thin film hydration technique. Calcein and greseofulvin release from liposomal gels using carbopol polymer was faster compared to hydroxyethyl cellulose and mixture gels [93]. Billard et al prepared an innovative hybrid formulation, which was composed of a water-soluble model molecule "carboxyfluorescein" in liposomal vesicles and dispersed in tridimensional matrix of chitosan hydrogel [94].…”

Section: Liposomes For Transdermal Delivery Of Drugsmentioning

confidence: 99%

Hydrogels and Their Combination with Liposomes, Niosomes, or Transfersomes for Dermal and Transdermal Drug Delivery

Ibrahim¹,

Nair²,

Al‐Dhubiab³

et al. 2017

Liposomes

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Polymeric networks that retain and absorb substantial amount of water or biological fluids and resemble as a biological tissue are defined as hydrogels. On the other hand, liposomes, transfersomes and niosomes are lipid carriers, which represent one of the major research and development focus areas of the pharmaceutical industry. They have great potential as lipid vehicles that are able to enhance permeation of drugs across the intact skin and can act as local depot for the drug to sustain and control its delivery. Lipid carrier and hydrogel combinations offer transdermal drug delivery of great potential to enhance systemic effects of both hydrophilic and lipophilic drugs. Also, lipid carriers can target drugs to skin appendages and improve transdermal delivery. Lipid carrier proform systems in the form of gelly liquid crystals can also be used transdermally for better drug absorption enhancement. This review highlights the potential of hydrogels and emulgels with or without lipid nanocarriers for dermal and transdermal application.

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Liposomes‐in‐Chitosan Hydrogels: Challenges and Opportunities for Biomedical Applications

Grijalvo

Eritja

Díaz

2019

Materials Science and Technology

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4 drug delivery (17) and tissue engineering (e.g. bone (18), cartilage (18,19) or neural (20) tissue regenerations). From the structural point of view, CS is a linear polysaccharide made of randomly distributed mixtures of deacetylated residues (β-(14)-linked-D-glucosamine) and acetylated residues (N-acetyl-Dglucosamine). This polysaccharide is commercially produced by deacetylation of chitin ( Figure 1A). The percentage of deacetylated and acetylated residues (so-called degree of deacetylation, DA) in CS determines its physicochemical properties as well as solubility (21), biodegradability and biological activity (22).The protonation of the amino groups on the CS backbone under acidic conditions permits the biopolymer solubility before reaching pH values that can range from 6.2 and 6.5. As a consequence, the amino groups of the Dgalactosamine units are predominantly positively charged at pH values below 6.2 (23, 24). The development of physical entanglements in CS hydrogels is governed by reversible non-covalent forces such as hydrogen, ionic and/or hydrophobic intermolecular interactions that depend on the pH, temperature, chemical composition and polymer chain length (24,25,26). Importantly, the robustness of CS-based hydrogels permits the incorporation of small molecules during the gelation process under mild conditions. In this regard, β-glycerophosphate (GP) has been described as an efficient catalyst to trigger the CS sol-to-gel transition at physiological pH. This process has led to transparent physically cross-linked hydrogels with potential use as injectable biomaterials (24) ( Figure 1B). Other small anionic molecules have also been described as effective ionic cross-linking agents including a) citrate and sulphates, b) transition metal ions like Pt (II) (27) or Mo (IV) (28), and c) the use

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Modulated release from liposomes entrapped in chitosan/gelatin hydrogels

Cited by 58 publications

References 30 publications

Chitosan‐based hydrogels: recent design concepts to tailor properties and functions

Chitosan‐based hydrogels: recent design concepts to tailor properties and functions

Hydrogels and Their Combination with Liposomes, Niosomes, or Transfersomes for Dermal and Transdermal Drug Delivery

Liposomes‐in‐Chitosan Hydrogels: Challenges and Opportunities for Biomedical Applications

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