Feynman stated that the double-slit experiment ". . . has in it the heart of quantum mechanics. In reality, it contains the only mystery" and that "nobody can give you a deeper explanation of this phenomenon than I have given; that is, a description of it" [Feynman R, Leighton R, Sands M (1965) The Feynman Lectures on Physics]. We rise to the challenge with an alternative to the wave function-centered interpretations: instead of a quantum wave passing through both slits, we have a localized particle with nonlocal interactions with the other slit. Key to this explanation is dynamical nonlocality, which naturally appears in the Heisenberg picture as nonlocal equations of motion. This insight led us to develop an approach to quantum mechanics which relies on preand postselection, weak measurements, deterministic, and modular variables. We consider those properties of a single particle that are deterministic to be primal. The Heisenberg picture allows us to specify the most complete enumeration of such deterministic properties in contrast to the Schrödinger wave function, which remains an ensemble property. We exercise this approach by analyzing a version of the double-slit experiment augmented with postselection, showing that only it and not the wave function approach can be accommodated within a time-symmetric interpretation, where interference appears even when the particle is localized. Although the Heisenberg and Schrödinger pictures are equivalent formulations, nevertheless, the framework presented here has led to insights, intuitions, and experiments that were missed from the old perspective.Heisenberg picture | two-state vector formalism | modular momentum | double slit experiment B eginning with de Broglie (1), the physics community embraced the idea of particle-wave duality expressed, for example, in the double-slit experiment. The wave-like nature of elementary particles was further enshrined in the Schrödinger equation, which describes the time evolution of quantum wave packets.It is often pointed out that the formal analogy between Schrödinger wave interference and classical wave interference allows us to interpret quantum phenomena in terms of the familiar classical notion of a wave. Indeed, wave-particle duality was construed by Bohr and others as the essence of the theory and, in fact, its main novelty. Even so, the foundations of quantum mechanics community have consistently raised many questions (2-5) centered on the physical meaning of the wave function.From our perspective and consistent with ideas first expressed by Born (6) and thereafter extensively developed by Ballentine (7, 8), a wave function represents an ensemble property as opposed to a property of an individual system.What then is the most thorough approach to ontological questions concerning single particles (using standard nonrelativistic quantum mechanics)? We propose an alternative interpretation for quantum mechanics relying on the Heisenberg picture, which although mathematically equivalent to the Schrödinger picture, is very dif...