Modular synthesis of dihydro-isoquinolines: palladium-catalyzed sequential C(sp²)–H and C(sp³)–H bond activation

Abstract

An efficient synthesis of dihydro-isoquinolines via a Pd–catalyzed double C–H bond activation/annulation featuring a short reaction time, high atom economy and the formation of a sterically less favoured tertiary C–N bond.

A comprehensive overview of directing groups applied in metal-catalysed C–H functionalisation chemistry

“…The group of Huang reported the synthesis of dihydro-isoquinolinones via a Pd(OAc) 2 catalysed alkylation–cyclisation sequence ( Scheme 38C ). 246 Initially, di- t butyl peroxide was the alkyl source and the reaction proceeded smoothly in cyclohexane, unfortunately requiring 25 equiv. of TFA.…”

Thiazolo[5,4-d]thiazole-based organic sensitizers with improved spectral properties for application in greenhouse-integrated dye-sensitized solar cells

“…Indeed, in the region of the spectrum utilized by plants (400-700 nm), oen referred to as the "photosynthetically active region" (PAR), not all light is converted with the same efficiency, with two peaks occurring in the blue (425-475 nm) and red (625-750 nm) parts of the spectrum, 12 corresponding to those regions where the most widespread forms of chlorophyll, A and B, as well as red and farred phytochromes, are active. [13][14][15] Green light, on the other hand, is not absorbed by chlorophylls and thus is less important for photosynthesis itself, although it has been reported that monochromatic irradiation with green light can alter chlorophyll composition in higher plants, 16 improve plant growth and morphology [17][18][19] and inuence the production of various metabolites. 20 Nevertheless, it has been shown that crops can be successfully cultivated under articial red/blue light, 21 suggesting that fabrication of solar cells capable of absorbing visible light mostly in the green region while signicantly transmitting blue and red wavelengths can constitute a promising approach towards development of a greenhouseintegrated PV system.…”

Comprehensive Strategies for the Synthesis of Isoquinolines: Progress Since 2008

“…In the year 2015, Liu et al reported the efficient synthesis of dihydroisoquinoline 254 via a Pd-catalyzed double CÀ H bond activation/annulation (CHAA). [150] The protocol presented here was beneficial with high atom economy and short reaction time and also focuses on activation of less reactive C(sp 3 )-H bond. The optimized condition was employed on variety of electron rich as well as electron poor benzamides and all of them returned with good to excellent yields.…”