Abstract. Consider the W-algebra H attached to the minimal nilpotent orbit in a simple Lie algebra g over an algebraically closed field of characteristic 0. We show that if an analogue of the Gelfand-Kirillov conjecture holds for such a W-algebra, then it holds for the universal enveloping algebra U(g). This, together with a result of A. Premet, implies that the analogue of the Gelfand-Kirillov conjecture fails for some W -algebras attached to the minimal nilpotent orbit in Lie algebras of types Bn (n ≥ 3), Dn (n ≥ 4), E 6 , E 7 , E 8 , and F 4 .