Modular imaging system: Rapid scan EPR at 800 MHz

Tseytlin, Oxana; Guggilapu, PriyaankaDevi; Bobko, Andrey A.; AlAhmad, Hussien; Xu, Xuan; Epel, Boris; O’Connell, Ryan; Hoblitzell, E Hannah; Eubank, Timothy D.; Khramtsov, Valery V.; Driesschaert, Benoît; Kazkaz, Eiad; Tseytlin, Mark

doi:10.1016/j.jmr.2019.06.003

Cited by 19 publications

(14 citation statements)

References 47 publications

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“…Work at the University of Denver along with the University of Maryland [ 7 – 12 ], the Ohio State University [ 13 – 18 ], Dartmouth [ 19 – 23 ], the University of Chicago [ 24 – 42 ], and the NIH [ 43 – 51 ] continues to demonstrate the utility of low-field EPR for pre-clinical EPR imaging. Expansion of these efforts continues at West Virginia University under the guidance of Tseytlin, Driesschaert and Khramtsov [ 52 – 55 ]. Low-field EPR spectroscopy and imaging applied to pre-clinical applications forms an outstanding basis from which to build in-field applications of materials analysis and non-destructive evaluation (NDE).…”

Section: Contributions To the Low Magnetic Field At The University Ofmentioning

confidence: 99%

“…Work at the University of Denver along with the University of Maryland [7][8][9][10][11][12], the Ohio State University [13][14][15][16][17][18], Dartmouth [19][20][21][22][23], the University of Chicago [24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42], and the NIH [43][44][45][46][47][48][49][50][51] continues to demonstrate the utility of low-field EPR for pre-clinical EPR imaging. Expansion of these efforts continues at West Virginia University under the guidance of Tseytlin, Driesschaert and Khramtsov [52][53][54]…”

Section: Contributions To the Low Magnetic Field At The University Of Denvermentioning

confidence: 99%

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EPR Everywhere

Biller

McPeak

2021

Appl Magn Reson

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This review is inspired by the contributions from the University of Denver group to low-field EPR, in honor of Professor Gareth Eaton's 80th birthday. The goal is to capture the spirit of innovation behind the body of work, especially as it pertains to development of new EPR techniques. The spirit of the DU EPR laboratory is one that never sought to limit what an EPR experiment could be, or how it could be applied. The most well-known example of this is the development and recent commercialization of rapid-scan EPR. Both of the Eatons have made it a point to remain knowledgeable on the newest developments in electronics and instrument design. To that end, our review touches on the use of miniaturized electronics and applications of single-board spectrometers based on software-defined radio (SDR) implementations and single-chip voltage-controlled oscillator (VCO) arrays. We also highlight several non-traditional approaches to the EPR experiment such as an EPR spectrometer with a "wand" form factor for analysis of the OxyChip, the EPR-MOUSE which enables non-destructive in situ analysis of many non-conforming samples, and interferometric EPR and frequency swept EPR as alternatives to classical high Q resonant structures.

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Section: Contributions To the Low Magnetic Field At The University Ofmentioning

confidence: 99%

Section: Contributions To the Low Magnetic Field At The University Of Denvermentioning

confidence: 99%

EPR Everywhere

Biller

McPeak

2021

Appl Magn Reson

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“…The original in vivo pulse EPR P O 2 imaging technique is due to the group of Murali Krisha at the National Cancer Institute (Bourg et al 1993). Recent in vivo spectral spatial images using rapid scan EPR have been developed by the Khramtsov group at West Virginia University (Tseytlin et al 2019).…”

Section: Fundamentals Of Epr Imagingmentioning

confidence: 99%

Biological validation of electron paramagnetic resonance (EPR) image oxygen thresholds in tissue

Gertsenshteyn

Giurcanu

Vaupel

et al. 2020

The Journal of Physiology

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Measuring molecular oxygen levels in vivo has been the cornerstone of understanding the effects of hypoxia in normal tissues and malignant tumors. Here we discuss the advances in a variety of partial pressure of oxygen (PnormalO2) measurements and imaging techniques and relevant oxygen thresholds. A focus on electron paramagnetic resonance (EPR) imaging shows the validation of treating hypoxic tumours with a threshold of PnormalO2 ≤ 10 Torr, and demonstrates utility for in vivo oxygen imaging, as well as its current and future role in cancer studies.

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“…A duration of field scanning of 3.8 milliseconds has been reported in state-of-the-art CW-EPR imaging (39). Moreover, rapid-scan EPR detection was developed and has been demonstrated to be a faster means of image acquisition (47). However, such state-of-theart hardware for EPR spectroscopy and imaging is available at only a few instrumentdevelopment laboratories.…”

Section: Introductionmentioning

confidence: 99%

Redox-Sensitive Mapping of a Mouse Tumor Model Using Sparse Projection Sampling of Electron Paramagnetic Resonance

Kimura

Iguchi

Nakano

et al. 2022

Antioxidants & Redox Signaling

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Aims: This work aimed to establish an accelerated imaging system for redox-sensitive mapping in a mouse tumor model using electron paramagnetic resonance (EPR) and nitroxyl radicals. Results: Sparse sampling of EPR spectral projections was demonstrated for a solution phantom. The reconstructed three-dimensional (3D) images with filtered back-projection (FBP) and compressed sensing (CS) image reconstruction were quantitatively assessed for the solution phantom. Mouse xenograft models of a human-derived pancreatic ductal adenocarcinoma cell line, MIA PaCa-2, were also measured for redox-sensitive mapping with the sparse sampling technique. Innovation: A short-lifetime redox-sensitive nitroxyl radical ( 15 N-labeled perdeuterated Tempone) could be measured to map the decay rates of the EPR signals for the mouse xenograft models. Acceleration of 3D EPR image acquisition broadened the choices of nitroxyl radical probes with various redox sensitivities to biological environments. Conclusion: Sparse sampling of EPR spectral projections accelerated image acquisition in the 3D redox-sensitive mapping of mouse tumor-bearing legs 4-fold compared to conventional image acquisition with FBP.

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Modular imaging system: Rapid scan EPR at 800 MHz

Cited by 19 publications

References 47 publications

EPR Everywhere

EPR Everywhere

Biological validation of electron paramagnetic resonance (EPR) image oxygen thresholds in tissue

Redox-Sensitive Mapping of a Mouse Tumor Model Using Sparse Projection Sampling of Electron Paramagnetic Resonance

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Modular imaging system: Rapid scan EPR at 800 MHz

Cited by 19 publications

References 47 publications

EPR Everywhere

EPR Everywhere

Biological validation of electron paramagnetic resonance (EPR) image oxygen thresholds in tissue

Redox-Sensitive Mapping of a Mouse Tumor Model Using Sparse Projection Sampling of Electron Paramagnetic Resonance

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Product

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Modular imaging system: Rapid scan EPR at 800 MHz