Modular fluorescence sensors for saccharides

Arimori, Susumu; Bell, Michael V.; Oh, Chahyun; Frimat, Karine A.; James, Tony D.

doi:10.1039/b108998f

Cited by 81 publications

(70 citation statements)

References 26 publications

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“…[32][33][34] Diboronic acid receptors with a 6 carbon linker between the 2 tertiary amines, Figure 5, have the a "stability order" of D-glucose > D-fructose > D-galactose >> D-mannose. 33 The GlySure CIGM Sensor glucose detecting chemistry based on the chemistry outlined above and which is immobilized within a hydrogel, is highly selective to glucose and because of the intramolecular quenching mechanism is particularly resistant to quenching by endogenous quenchers. The fluorophore used is not sensitive to pH/pO 2 and is therefore not sensitive to physiological changes.…”

Section: Receptor Chemistrymentioning

confidence: 99%

The Development of a Continuous Intravascular Glucose Monitoring Sensor

Crane¹,

Barwell²,

Gopal³

et al. 2015

J Diabetes Sci Technol

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Background: Glycemic control in hospital intensive care units (ICU) has been the subject of numerous research publications and debate over the past 2 decades. There have been multiple studies showing the benefit of ICU glucose control in reducing both morbidity and mortality. GlySure Ltd has developed a glucose monitor based on a diboronic acid receptor that can continuously measure plasma glucose concentrations directly in a patient’s vascular system. The goal of this study was to validate the performance of the GlySure CIGM system in different patient populations. Methods: The GlySure Continuous Intravascular Glucose Monitoring (CIGM) System was evaluated in both the Cardiac ICU (33 patients) and MICU setting (14 patients). The sensor was placed through a custom CVC and measured the patients’ blood glucose concentration every 15 seconds. Comparison blood samples were taken at 2 hourly then 4 hourly intervals and measured on a YSI 2300 STAT Plus or an i-STAT. Results: Consensus error grid analysis of the data shows that the majority of the data (88.2% Cardiac, and 95.0% MICU) fell within zone A, which is considered to be clinically accurate and all data points fell within zones A and B. The MARD of the Cardiac trial was 9.90% and the MICU trial had a MARD of 7.95%. Data analysis showed no significant differences between data generated from Cardiac and MICU patients or by time or glucose concentration. Conclusions: The GlySure CIGM System has met the design challenges of measuring intravascular glucose concentrations in critically ill patients with acceptable safety and performance criteria and without disrupting current clinical practice. The accuracy of the data is not affected by the patients’ condition.

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Section: Receptor Chemistrymentioning

confidence: 99%

The Development of a Continuous Intravascular Glucose Monitoring Sensor

Crane¹,

Barwell²,

Gopal³

et al. 2015

J Diabetes Sci Technol

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“…This reaction results from the boronic acids hydroxyl groups strong interactions with the diol-containing saccharides, forming cyclic boronic acid esters on complexation. Recently, a number of studies have been made with respect to the selective recognition of saccharides and their detection using boronic acid-diol interactions [8][9][10]. Shoji and Freund reported that using a poly(aniline boronic acid) (PABA) modified electrode, the electrochemical potential was sensitive to sugars, due to the formation of a boronic acid-diol complex that caused the fluctuation of the pKa of PABA [8].…”

Section: Introductionmentioning

confidence: 99%

“…Shoji and Freund reported that using a poly(aniline boronic acid) (PABA) modified electrode, the electrochemical potential was sensitive to sugars, due to the formation of a boronic acid-diol complex that caused the fluctuation of the pKa of PABA [8]. Arimori and co-workers synthesized a novel compound that combined the boronic acid receptor and a pyrene unit into a transducer for a d-glucose fluorescence sensor [9]. Also reported, by Park et al, was a thiophene-3-boronic acid modified gold electrode with selectivity for HbA 1c that employed a quartz crystal [10].…”

Section: Introductionmentioning

confidence: 99%

A Nonenzymatic Amperometric Method for Fructosyl‐Valine Sensing Using Ferroceneboronic Acid

Chien

Chou

2010

Electroanalysis

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Fructosyl valine (Fru-Val) is a glycosylated component of hemoglobin (HbA 1c ) that can serve as a diagnostic target for type 2 diabetes. While average blood glucose levels fluctuate significantly, the more stable levels of HbA 1c can serve as a better long-term diagnostic marker. Here a diagnostic system, incorporating an amperometric method, for detecting Fru-Val (at + 0.1 V vs. Ag/AgCl), using ferrocene boronic acid (FcBA) is presented. FcBA can complex diols, and has easily detectable redox properties. The boronic acid group in FcBA mediates complexation, while the Fe(II)/Fe(III) couple serves as a transducer. The diagnostic system, based on a miniaturized bare glassy carbon paste electrode (GCPE), has a fast response time.

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“…There are relatively few studies, however, addressing the simultaneous detection of common sugars, such as glucose and fructose, in mixtures [1,2]. It has been known for decades that boronic acids exhibit relatively high affinity for fructose compared to other saccharides [3].…”

Section: Introductionmentioning

confidence: 99%

Macrocycle-Derived Functional Xanthenes and Progress Towards Concurrent Detection of Glucose and Fructose

Rusin

Alptürk

et al. 2004

Journal of Fluorescence

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The detection of saccharides in biological media is of great current importance for the monitoring of disease states. We have previously reported that solutions of boronic acid-functionalized macrocycles form acyclic oligomeric materials in situ. The oligomers contain fluorescent xanthene moieties. Current efforts are aimed at modulating the spectroscopic responses of these materials for the analysis of specific sugars. We describe conditions whereby the xanthene boronic acids exhibit high colorimetric fructose selectivity. In contrast, at physiological levels selective glucose monitoring can be achieved via fluorescence. Additionally, we describe a method which exhibits promise for detecting both glucose and fructose at dual wavelengths in the UV-Vis region. Mechanistic rationale for each of these findings is presented.

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Modular fluorescence sensors for saccharides

Cited by 81 publications

References 26 publications

The Development of a Continuous Intravascular Glucose Monitoring Sensor

The Development of a Continuous Intravascular Glucose Monitoring Sensor

A Nonenzymatic Amperometric Method for Fructosyl‐Valine Sensing Using Ferroceneboronic Acid

Macrocycle-Derived Functional Xanthenes and Progress Towards Concurrent Detection of Glucose and Fructose

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