Modular Approach to Highly Substituted 3-Methylpyridones

Abstract

A method has been developed for the rapid synthesis of highly substituted 3-methylpyridones via the condensation of Baylis− Hillman amines and ketones under benzoic acid catalysis. The process features readily available starting materials, broad substrate scope, high functional group tolerance, excellent regioselectivity, and gram-scale synthesis. We envision that this on-demand construction of 3-methylpyridones will provide exciting opportunities in biological research, therapeutics, and material sciences