Modifying effects of histamine on circadian rhythms and neuronal excitability

Histamine H3 receptor as a potential target for cognitive symptoms in neuropsychiatric diseases

“…Moreover, it has been found that H1R antagonists increased the incidence of seizures in children [150]. Furthermore, abnormal levels of H1Rs around the focus of epileptic injury in complex partial seizures were noticed in human positron emission tomography studies [151]. Several clinical results showedthat around 60-70 % of patients respond to treatment and resistance to mono-therapy is not uncommon and drug combination is often inevitable [152].…”

Neuropharmacology of Histamine in Brain

“…The role of histaminergic neurons in preventing seizures, or even the development of epileptogenesis, presumably, in most cases, via H 1 receptor activation, has been shown in several rodent models of epilepsy [516,517]. In agreement, drug-induced changes in histamine synthesis, release, or metabolism confirmed the role of the endogenous amine acting via the H 1 receptor in preventing seizure activity elicited in rodents by pentetrazole, transcranial electrical stimulation, or amygdaloid kindling.…”

Involvement of histamine receptors in the atypical antipsychotic profile of clozapine: a reassessment in vitro and in vivo

“…Interaction of clozapine and NDMC with histamine receptors may also account for this side effect. Histaminergic neurons prevent seizures via H 1 R activation (Kamei 2001;Tuomisto et al 2001;Yokoyama 2001). Consistently, H 1 R-deficient mice develop kindling (Chen et al 2003;Hirai et al 2004), H 1 R antagonists tend to promote seizures in epileptic patients (Sangalli 1997), and, in contrast, histamine release induced by H 3 R inverse agonists inhibits seizures (Kamei 2001).…”