Modifying effect of dietary sesaminol glucosides on the formation of azoxymethane-induced premalignant lesions of rat colon

Sheng, Hongqiang; Hirose, Yoshinobu; Hata, Koichiro; Zheng, Qiao; Kuno, Toshiki; Asano, Nami; Yamada, Yasuhiro; Hara, Akira; Osawa, Toshihiko; Mori, Hideki

doi:10.1016/j.canlet.2006.01.030

Cited by 33 publications

(19 citation statements)

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“…20) SG has also been shown to have a host of other physiological effects including anti-inflammatory and anticarcinogenic effects. 16,43) Our results, taken with these findings, suggest that the anti-apoptotic properties of SG account for the ability of SG prevent Ab [25][26][27][28][29][30][31][32][33][34][35] -induced learning and memory deficits.…”

Section: Discussionmentioning

confidence: 58%

Sesaminol Glucosides Protect .BETA.-Amyloid Peptide-Induced Cognitive Deficits in Mice

Ahn

Kim

et al. 2009

Biological & Pharmaceutical Bulletin

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Alzheimer's disease (AD) is characterized by progressive cognitive function deficits due to the presence of numerous senile plaques and neurofibrillary tangles in certain brain regions.1) The main component of senile plaques is b-amyloid peptide (Ab), which is derived from a large amyloid precursor protein (APP).2) Ab 25-35 contains the residues important for aggregation and toxicity including methionine 35.3) This amyloid fragment has been shown to induce neurotoxicity in vitro as well as in vivo. 4,5) In addition, the intracerebroventricular (i.c.v.) administration of Ab 25-35 into rodent brain induced histological change and cognitive deficit.6,7) The deposition of Ab may cause neuronal death via a number of possible mechanisms including oxidative stress and inflammatory response, which has been suggested to play a key role in AD pathogenesis. 2)Oxidative stress has been hypothesized to play a pivotal role in excitotoxicity, inflammation, and apoptosis in the AD brain. Marker of oxidative stress such as lipid peroxides, protein carbonyl groups, and 8-hydroxyl-2Ј-deoxyguanosine (8-OHdG) are increased in the brains of AD patients than in aged-matched control brains. 8,9) Moreover, it has been reported that Ab induces neurotoxicity via oxidative stress, and some antioxidants, such as vitamin E and ferulic acid, protect neurons from Ab-induced apoptosis. 4,10,11) Therefore, the attenuation of oxidative stress through antioxidant therapies may be useful in the treatment/prevention of AD. 12)Sesame (Sesamum indicum LINN.) is widely known as a natural healthy food, and contains sesame lignan and lignan glycosides.13) Sesame lignan compounds, including sesamin gludosides (SG), have been shown to inhibit endogenous lipid peroxidation as well as oxidative DNA damage in rat liver and kidney.14) These compounds also scavenge peroxyradicals in in vitro experimental systems. [15][16][17] Kang et al. 18) have reported that defatted sesame flour containing SG inhibits lipid peroxidation in hypercholesterolemic rabbits. We also observed that SG had a protective effect against Ab induced neuronal cell death 19) and showed an inhibitory effect on lipopolysaccharide (LPS)-induced inflammatory response in astrocytes. 20) Taking those facts into account, we hypothesized that SG exerts a neuroprotective effect in AD.Since the effect of SG on cognitive function has not been reported, we investigated whether SG can exhibit the protective effect on the Ab 25-35 -induced cognitive impairments. MATERIALS AND METHODSSample Preparation SG isolated form sesame seed was prepared according to the method described by Katsuzaki et al.13) Deffated sesame flour was extracted with distilled water at 95°C for 1 h to obtain a crude extract containing sesaminol glucosides. Crude SG was further purified by Diaion HP 20 (Mitsubishi Chemicals, Co., Tokyo, Japan) column using 60% ethanol. The extracts were concentrated under reduced pressure and freeze-dried for storage until use. Total SG content of the extract was determined by UV spectroscopy, and th...

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Section: Discussionmentioning

confidence: 58%

Sesaminol Glucosides Protect .BETA.-Amyloid Peptide-Induced Cognitive Deficits in Mice

Ahn

Kim

et al. 2009

Biological & Pharmaceutical Bulletin

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“…Sesaminol also has inhibitory effect on inflammatory hepatic ischemia-reperfusion injury in rats (Utsunomiya et al, 2003). In a recent study, it was clearly confirmed that dietary sesaminol glucosides (SGs) inhibited the development of colonic precancerous lesions in vivo (Sheng et al, 2007). The beneficial effect of SGs might be attributed to the antioxidative property and/or downregulation of serum triglycerides (Table 2).…”

Section: Sesaminolmentioning

confidence: 90%

“…The beneficial effect of SGs might be attributed to the antioxidative property and/or downregulation of serum triglycerides (Table 2). Recently, Sheng et al (2007) stated dietary SGs may be a promising chemopreventive agent against colon cancer. It needs to verify if this could be applicable to humans as the study was conducted on rats.…”

Section: Sesaminolmentioning

confidence: 99%

“…Literatures have reported a number of health benefits accruing from the consumption of sesame seeds and sesame oil (Namiki, 1995;Yamashita et al, 1995;Hirata et al, 1996;Abou-Gharbia et al, 1997;Nakano et al, 2002). Sesame seed has been recently of particular interest as a promising source for preventing or slowing carcinogenesis by means of continual administration of its beneficial compound(s) with few side effects (Sheng et al, 2007). Other health promoting effects are mainly attributed to the high mono unsaturated fatty acids such as linoleic acid (Katsuzaki et al, 1994), and the different bioactive components in sesame including phytosterols, tocopherol, and lignans (Sugano et al, 1990;Kang et al, 1999).…”

Section: Introductionmentioning

confidence: 99%

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Nutraceutical Importance of Sesame Seed and Oil: A Review of the Contribution of their Lignans

Kanu¹,

Bahsoon²,

Kanu³

et al. 2010

Sierra Leone j. biomed. res.

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Sesame seed is widely used in food and nutraceutical industries in many countries because of its high oil, protein and antioxidant contents. Sesame oil contains sesamin, sesamolin and sesaminol lignan fractions, which are known to play an important role in its oxidative stability and antioxidative activity. It is widely known as one of the natural health promoting foods that has the potential to prevent various disorders such as hypertension, hypercholesterolemia cancer and aging. Additionally, sesame oil may be useful in managing oxidative stress-associated diseases such as atherosclerosis, diabetes mellitus, obesity, chronic renal failure, rheumatoid arthritis, and neurodegenerative diseases including Alzheimer's disease. Moreover, sesame oil has multiple physiological functions such as decreasing blood lipids and arachidonic acid levels, increasing antioxidative ability and γ-tocopherol bioavailability, and providing anti-inflammatory function and potential estrogenic activity. Many health promoting effects are attributed to its lignans. Hence, this article highlights and discusses the potential health promoting effects of sesame and its oil with emphasis on the contribution of lignans.

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“…Although the sesaminol glucosides (SGs) directly have no role in antioxidative defense system against various oxidative damages, they could be hydrolyzed to form sesaminol by intestinal beta-glucosidase after ingestion of sesame seeds, thereby working as antioxidants (Katsuzaki et al 1994 ). In a recent study, it was confi rmed that dietary sesaminol glucosides (SGs) inhibited the development of colonic precancerous lesions in vivo (Sheng et al 2007 ). The benefi cial effect of SGs might be attributed to the antioxidative property and/or downregulation of serum triglycerides.…”

Section: Sesaminolmentioning

confidence: 99%

Vegetable Oil-Based Nutraceuticals

Karuna

2015

Plant Biology and Biotechnology

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Nutraceutical is a part of food that provides medicinal or health benefi ts including the prevention and treatment of diseases in addition to the common nutritional values of the foodstuff. Nutraceuticals provide all the essential substances which are supposed to be present in human diet. It is one of the fastest-growing segments of the global food industry and may range from isolated nutrients, dietary supplements, antioxidants, minerals, functional fi bers, probiotics and prebiotics, marine products, functional foods and beverages, phytochemicals, dairy-based ingredients, confectionary products, and cosmeceuticals. Vegetable oil is a rich source of nutraceuticals in addition to essential fatty acids. Triglyceride is the major component of the vegetable oil, and its fatty acids play a vital role in human health and nutrition. Minor components of vegetable oil such as lecithin, tocopherols and tocotrienols, phytosterols and phytostanols, oryzanol, policosanol, squalene, carotenoids, and lignans also play a significant role in human health. This chapter describes the importance of vegetable oil-based nutraceuticals.

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Modifying effect of dietary sesaminol glucosides on the formation of azoxymethane-induced premalignant lesions of rat colon

Cited by 33 publications

References 30 publications

Sesaminol Glucosides Protect .BETA.-Amyloid Peptide-Induced Cognitive Deficits in Mice

Sesaminol Glucosides Protect .BETA.-Amyloid Peptide-Induced Cognitive Deficits in Mice

Nutraceutical Importance of Sesame Seed and Oil: A Review of the Contribution of their Lignans

Vegetable Oil-Based Nutraceuticals

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