Modifier-assisted differential mobility–tandem mass spectrometry method for detection and quantification of amphetamine-type stimulants in urine

Chen, Pai‐Shan; Chen, Shuhua; Chen, Jung-Hsuan; Haung, Wan-Yun; Liu, Hsin-Tung; Kong, Po-Hsin; Yang, Olivia Hsu-Yuan

doi:10.1016/j.aca.2016.09.027

Cited by 21 publications

(14 citation statements)

References 44 publications

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“…This leads to the possibility of studying changes in molecular conformation over a large range of drift gas temperatures. Another promising technique enabled by AP‐DTIMS is the addition of liquid gas modifier such as methanol or propanol for further separation improvement.…”

Section: Introduction: Instrumentation Highlightsmentioning

confidence: 99%

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Separation of biologically relevant isomers on an Orbitrap mass spectrometer using high‐resolution drift tube ion mobility and varied drift gas mixtures

Kaszycki

Rotta

Colsch

et al. 2019

Rapid Comm Mass Spectrometry

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Rationale Atmospheric pressure drift tube ion mobility is a powerful addition to the Orbitrap mass spectrometer enabling direct separation of isomers. Apart from offering high resolving power in a compact design, it also facilitates optimization of the separation gas, as shown here for a series of biologically relevant isomer pairs. Methods An Excellims MA3100 High‐Resolution Atmospheric Pressure Ion Mobility Spectrometer (HR‐IMS) was coupled to a Thermo Scientific™ Q Exactive™ Focus hybrid quadrupole–Orbitrap™ mass spectrometer, using an Excellims Directspray™ Electrospray Ionization source and a gas mixture setup to provide various drift gases (air, CO2 and mixtures). This instrument combination was used to separate isomers of eight pairs of metabolites and gangliosides, optimizing drift gas conditions for best separation of each set. Results All but one of the isomers pairs provided could be partially or fully separated by the HR‐IMS‐MS combination using ion mobility drift times. About half of the separated compounds showed significantly better analytical separation when analyzed in a mixture of CO2 and air rather than air or CO2 alone. Resolving power of up to 102 was achieved using the 10 cm atmospheric drift tube ion mobility add‐on for the Orbitrap mass spectrometer. Conclusions The present analysis demonstrates the usefulness of using atmospheric drift tube IMS on an Orbitrap mass spectrometer to characterize the isomeric composition of samples. It also highlights the potential benefits of being able to quickly optimize the drift gas composition to selectively maximize the mobility difference for isomer separation.

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Section: Introduction: Instrumentation Highlightsmentioning

confidence: 99%

“…Another promising technique enabled by AP-DTIMS is the addition of liquid gas modifier such as methanol 24 or propanol 25 for further separation improvement.…”

Section: Introduction: Instrumentation Highlightsmentioning

confidence: 99%

Separation of biologically relevant isomers on an Orbitrap mass spectrometer using high‐resolution drift tube ion mobility and varied drift gas mixtures

Kaszycki

Rotta

Colsch

et al. 2019

Rapid Comm Mass Spectrometry

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“…[36][37] The term modifier-assisted DMS-MS/MS method for detection and quantification of metabolites in complex samples has been coined recently. 38 By seeding polar molecules in the carrier gas, differential mobility between low and high electric field change. During each cycle of the waveform applied to the DMS electrodes, clustering and declustering phenomena is assumed to occur at low and high electric field, respectively.…”

Section: Resultsmentioning

confidence: 99%

Infrared isomer-specific fragmentation for the identification of aminobutyric acid isomers separated by differential mobility spectrometry

Wang

Alhajji

Rieul

et al. 2019

International Journal of Mass Spectrometry

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Highlights: First results based on the coupling of differential mobility spectrometry and infrared multiple photon dissociation spectroscopy with high resolution FT-ICR mass spectrometry are presented  Two operation modes of the DMS-MS/MS(IRMPD) are illustrated for the structural assignment of DMS peaks associated with three structural isomers of aminobutyric acids  Peak assignment and structural identification is performed through IRMPD spectroscopy of DMS-and mass-selected ions  Peak assignment and structural characterization can also be based on selected DMS peak depletion at selected IR wavelengths.

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“…MeOH, propanol, butanol, hexanol, heptanol) and various transport gas (i.e. nitrogen, helium, argon, carbon dioxide) [301]. The authors concluded that the combination of He and MeOH allows achieving the best sensitivity and selectivity for the investigated mixture of compounds.…”

Section: Improving Orthogonality Between Ion Mobility and Msmentioning

confidence: 98%

Adding a new separation dimension to MS and LC–MS: What is the utility of ion mobility spectrometry?

D’Atri

Causon

Hernandez‐Alba

et al. 2017

J of Separation Science

148

142

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* These authors contributed equally.Ion mobility spectrometry is an analytical technique known for more than 100 years, which entails separating ions in the gas phase based on their size, shape, and charge. While ion mobility spectrometry alone can be useful for some applications (mostly security analysis for detecting certain classes of narcotics and explosives), it becomes even more powerful in combination with mass spectrometry and high-performance liquid chromatography. Indeed, the limited resolving power of ion mobility spectrometry alone can be tackled when combining this analytical strategy with mass spectrometry or liquid chromatography with mass spectrometry. Over the last few years, the hyphenation of ion mobility spectrometry to mass spectrometry or liquid chromatography with mass spectrometry has attracted more and more interest, with significant progresses in both technical advances and pioneering applications. This review describes the theoretical background, available technologies, and future capabilities of these techniques. It also highlights a wide range of applications, from small molecules (natural products,

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Modifier-assisted differential mobility–tandem mass spectrometry method for detection and quantification of amphetamine-type stimulants in urine

Cited by 21 publications

References 44 publications

Separation of biologically relevant isomers on an Orbitrap mass spectrometer using high‐resolution drift tube ion mobility and varied drift gas mixtures

Separation of biologically relevant isomers on an Orbitrap mass spectrometer using high‐resolution drift tube ion mobility and varied drift gas mixtures

Infrared isomer-specific fragmentation for the identification of aminobutyric acid isomers separated by differential mobility spectrometry

Adding a new separation dimension to MS and LC–MS: What is the utility of ion mobility spectrometry?

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