The MSD phenomenon is an active research topic of the academic and the aviation industry. This paper puts emphasis on the multi-crack propagation with interactive effects of MSD structure in 2524-T3 aluminium alloy. Material tests were accomplished for the crack growth parameters. The multi-crack propagation tests were conducted on specimens containing 5-similar-details, and the corresponding fatigue crack growth analysis with a fast prediction of crack growth life method were accomplished with finite element software. The comparison of crack tip position vs. load cycling from the test and the numerical simulation shows that the numerical simulation can give a good agreement to the experiment result.