Modified Screen Printed Electrode for Selective Determination of Folic Acid

Abstract

Folic acid (FA) as one of the water-soluble vitamins contributes to the construction of healthy cells, as FA deficiency is one of the leading causes of anaemia. Based on reports, reduced folate level can lead to development of carcinogenesis. Hence, its analysis from the clinical point of view is highly demanded. In the present work, NiFe 2 O 4 nanoparticles was successfully synthesized and used for modified novel voltammetric sensor for determination of folic acid. Differential pulse voltammetry response shows the linear increment of oxidation signals with an increase in the concentration of folic acid in the range of 1.0 × 10-7-5.0 × 10-4 M with limit of detection 3.4 × 10-8 M. The modified electrode displays an excellent selectivity towards the determination of FA even in the presence of various interfering species. Finally, the screen printed electrode (SPE) consists of three main parts which are a graphite counter electrode, a silver pseudo-reference electrode and a graphite working electrode modified by NiFe 2 O 4 nanoparticles (NFO), and was applied for FA determination folic acid in tablet and urine samples whose accuracy was attested by means of addition and recovery assays (97.0-103.5%) as well as by differential pulse voltammetry.

Screen printed carbon electrode from coconut shell char for lead ions detection

“…12(b). The current response increases proportionally as the scan rate increases, indicating a good working electrode response to deliver current (Herawati et al, 2017) and referring to a diffusion-controlled mechanism for reaction (Safaei et al, 2019) at the surface of SPAC700-Fc30. Scan rate of 3 mVs -1 was too low to produce a high current density.…”

Ag nanoparticles supported on a magnetic NiFe2O4/MIL-101(Fe) metal–organic framework nanocomposite for the room temperature rapid catalytic reduction of nitrophenols and nitroanilines

“…From comparing the patterns, it is concluded that the diffraction peaks that appeared at 2y = 381, 441, 651 and 771 in the XRD pattern of the Ag@NiFe 2 O 4 /MIL101(Fe) composite correspond to silver nanoparticles. 66 The diffraction peaks appearing at 301, 361, 461, 571 and 631 belong to nickel ferrite. [67][68][69][70] Also, the peaks appearing at 2y less than 201 indicate the presence of MIL101(Fe).…”

Determination of Folic Acid Using Biosensors—A Short Review of Recent Progress

“…Safaei et al [ 64 ], in 2019, successfully synthesized and used NiFe 2 O 4 (NFO) nanoparticles in order to develop a modified novel voltammetric sensor for determination of FA in urine samples. The morphological characterization of NFO nanoparticles was examined by means of scanning-electron microscopy (SEM), and it was observed that all the particles are nearly spherical, not agglomerated and less than 10 nm.…”

“…( C ): CVs of NFO/SPE in 0.1 M PBS (pH 7) containing 150 µM of FA at various scan rates; numbers 1–12 correspond to 10, 25, 50, 75, 100, 200, 300, 400, 500, 600, 700 and 800 mV s −1 , respectively. Inset: variation of anodic peak current vs. square root of scan rate [ 64 ].…”