Modified pullulan nanoparticles for oral delivery of lopinavir: Formulation and pharmacokinetic evaluation

Ravi, Punna Rao; Vats, Rahul; Balija, Jagadeesh; Adapa, Sathya Prabhu Naidu; Aditya, N.P.

doi:10.1016/j.carbpol.2014.03.099

Cited by 53 publications

(22 citation statements)

References 33 publications

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“…By comparing different classes of dendrimers differing in their surface coating, including dendrimers coated with sialic acid (sialic acid conjugated polypropylenimine (PPI) dendrimers (SPPI)), with mannose (mannose conjugated PPI dendrimers (MPPI)) or with both sialic acid and mannose (sialic acid conjugated-mannosylated PPI dendrimers (SMPPI)), they concluded that both sialic acid and mannose receptors cooperate in macrophagic uptake of these nanoparticles with additive effects. Macrophagic accumulation and high disposition in the spleen have been demonstrated also for the protease inhibitors lopinavir loaded in modified pullulan nanoparticles [151] and for nanoformulated atazanavir [152]. …”

Section: Role Of the Spleen In The Pharmacokinetics Of Nanoparticlmentioning

confidence: 99%

Emerging Role of the Spleen in the Pharmacokinetics of Monoclonal Antibodies, Nanoparticles and Exosomes

Cataldi

Vigliotti

Mosca

et al. 2017

IJMS

197

151

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After being absorbed, drugs distribute in the body in part to reach target tissues, in part to be disposed in tissues where they do not exert clinically-relevant effects. Therapeutically-relevant effects are usually terminated by drug metabolism and/or elimination. The role that has been traditionally ascribed to the spleen in these fundamental pharmacokinetic processes was definitely marginal. However, due to its high blood flow and to the characteristics of its microcirculation, this organ would be expected to be significantly exposed to large, new generation drugs that can hardly penetrate in other tissues with tight endothelial barriers. In the present review, we examine the involvement of the spleen in the disposition of monoclonal antibodies, nanoparticles and exosomes and the possible implications for their therapeutic efficacy and toxicity. The data that we will review lead to the conclusion that a new role is emerging for the spleen in the pharmacokinetics of new generation drugs, hence suggesting that this small, neglected organ will certainly deserve stronger attention by pharmacologists in the future.

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Section: Role Of the Spleen In The Pharmacokinetics Of Nanoparticlmentioning

confidence: 99%

Emerging Role of the Spleen in the Pharmacokinetics of Monoclonal Antibodies, Nanoparticles and Exosomes

Cataldi

Vigliotti

Mosca

et al. 2017

IJMS

197

151

View full text Add to dashboard Cite

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“…This is because, in the drug‐loaded nanocarrier system, the drug is not available in free form. The plasma drug exposure of drug‐loaded nanocarrier system administered through any extravascular route is dependent on the absorption and disposition properties of the carrier system and how the loaded drug releases from the carrier system in the blood …”

Section: Introductionmentioning

confidence: 99%

“…The plasma drug exposure of drug-loaded nanocarrier system administered through any extravascular route is dependent on the absorption and disposition properties of the carrier system and how the loaded drug releases from the carrier system in the blood. [13,[17][18][19] It is anticipated that in patients with HIV/TB co-infection, where there are chances of drug-induced hepatotoxicity, dose adjustment (reduction) of LPV (conventional formulations) can lead to a further decrease in distribution of drug to viral reservoirs. On contrary to this, in hepatotoxic condition, nanocarrier delivery systems like SLNs would be more efficient in preventing undue plasma exposure compared with conventional formulations of LPV.…”

Section: Introductionmentioning

confidence: 99%

Comparative pharmacokinetic evaluation of lopinavir and lopinavir-loaded solid lipid nanoparticles in hepatic impaired rat model

Ravi

Vats

2017

Journal of Pharmacy and Pharmacology

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“…[28] This polysaccharide is especially used as a coating material in the food and pharmaceutical industries due to its non-toxic, water-soluble, colorless, tasteless, odorless, and heat-stable characteristics. [29] Ravi and Vats [30] developed pullulan nanoparticles for the delivery of human immunodeficiency virus (HIV) protease inhibitor Laponivar. According to the results of this study, it was observed that high microencapsulation efficiency values were obtained.…”

Section: Introductionmentioning

confidence: 99%

Whey Protein-Pullulan (WP/Pullulan) Polymer Blend for Preservation of Viability ofLactobacillus acidophilus

Çabuk

Harsa

2015

Drying Technology

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In this study, whey protein isolate-pullulan (WP/pullulan) microspheres were developed to entrap the probiotic Lactobacillus acidophilus NRRL-B 4495 by spray-drying technique. Microcapsules were analyzed for physicochemical characteristics including morphology, particle size, moisture content, water activity, dissolution time, and color properties. Results revealed that microcapsules were spherical in shape and obtained particle sizes between 5 and 160 lm, with an average size of around 50 lm. Blending pullulan with WP provided enhanced survival of probiotic bacteria during spray drying with a final viable cell number of 8.81 log CFU/g of microcapsule. Encapsulated probiotics were also found to have significantly (p 0.05) higher survived cell numbers compared to free probiotics under detrimental gastrointestinal conditions. Moreover, dissolution analysis suggested that protein-polysaccharide powdered microcapsules showed pH-sensitive dissolution properties in simulated gastric juice and simulated intestinal juice.

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Modified pullulan nanoparticles for oral delivery of lopinavir: Formulation and pharmacokinetic evaluation

Cited by 53 publications

References 33 publications

Emerging Role of the Spleen in the Pharmacokinetics of Monoclonal Antibodies, Nanoparticles and Exosomes

Emerging Role of the Spleen in the Pharmacokinetics of Monoclonal Antibodies, Nanoparticles and Exosomes

Comparative pharmacokinetic evaluation of lopinavir and lopinavir-loaded solid lipid nanoparticles in hepatic impaired rat model

Whey Protein-Pullulan (WP/Pullulan) Polymer Blend for Preservation of Viability ofLactobacillus acidophilus

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