Modified porous carboxymethyl chitin microspheres by an organic solvent-free process for rapid hemostasis

Leng, Fan; Chen, Feixiang; Jiang, Xulin

doi:10.1016/j.carbpol.2021.118348

Cited by 36 publications

(18 citation statements)

References 46 publications

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“…In the presented study, electrospray was utilized to fabricate the chitosan microspheres. Compared with microspheres fabricated via emulsion technology, this method did not incorporate any organic solvent which could lead to undesired toxicity once adhered to microspheres during the fabrication process [ 35 ]. During the collection of these microspheres, the lower temperature generated by liquid nitrogen is beneficial to the shape maintenance of obtained microspheres and pharmacological activities of encapsulated drugs, especially for the delivery of nucleic acids and proteins.…”

Section: Resultsmentioning

confidence: 99%

Injectable, Anti-Cancer Drug-Eluted Chitosan Microspheres against Osteosarcoma

Zhao

Tian

Shang

et al. 2022

JFB

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The purpose of this study is to fabricate different anti-cancer drug-eluted chitosan microspheres for combination therapy of osteosarcoma. In this study, electrospray in combination with ground liquid nitrogen was utilized to manufacture the microspheres. The size of obtained chitosan microspheres was uniform, and the average diameter was 532 μm. The model drug release rate and biodegradation rate of chitosan microspheres could be controlled by the glutaraldehyde vapor crosslinking time. Then the 5-fluorouracil (5-FU), paclitaxel (PTX), and Cis-dichlorodiammine-platinum (CDDP) eluted chitosan microspheres were prepared, and two osteosarcoma cell lines, namely, HOS and MG-63, were selected as cell models for in vitro demonstration. We found the 5-FU microspheres, PTX microspheres, and CDDP microspheres could significantly inhibit the growth and migration of both HOS and MG-63 cells. The apoptosis of both cells treated with 5-FU microspheres, PTX microspheres, and CDDP microspheres was significantly increased compared to the counterparts of control and blank groups. The anti-cancer drug-eluted chitosan microspheres show great potential for the treatment of osteosarcoma.

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Section: Resultsmentioning

confidence: 99%

Injectable, Anti-Cancer Drug-Eluted Chitosan Microspheres against Osteosarcoma

Zhao

Tian

Shang

et al. 2022

JFB

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“…They can be applied to the surface of almost any solid material, including metals, hydrogels, or polymers. The PDA coating is capable of enhancing bioactivity and cell adhesion on microhydrogel materials due to the enrichment of active groups. , In addition, amino and catechol groups are present in large amounts in PDA coatings, which can provide an important reaction platform for a secondary reaction and further functional modification of the material. − In order to repair critical-size bone defects, vascularization is crucial. Early vascular regeneration recruits more stem cells to the defect area and facilitates the supply of nutrients and oxygen. , Thus, in this study, vascular endothelial growth factor (VEGF) was loaded on the surface of PDA-functionalized Sr-Alg/nHA microhydrogels.…”

Section: Introductionmentioning

confidence: 99%

Polydopamine-Functionalized Strontium Alginate/Hydroxyapatite Composite Microhydrogel Loaded with Vascular Endothelial Growth Factor Promotes Bone Formation and Angiogenesis

Chen,

Cheng,

Bao

et al. 2024

ACS Appl. Mater. Interfaces

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Critical-size bone defects are a common and intractable clinical problem that typically requires filling in with surgical implants to facilitate bone regeneration. Considering the limitations of autologous bone and allogeneic bone in clinical applications, such as secondary damage or immunogenicity, injectable microhydrogels with osteogenic and angiogenic effects have received considerable attention. Herein, polydopamine (PDA)-functionalized strontium alginate/nanohydroxyapatite (Sr-Alg/nHA) composite microhydrogels loaded with vascular endothelial growth factor (VEGF) were prepared using microfluidic technology. This composite microhydrogel released strontium ions stably for at least 42 days to promote bone formation. The PDA coating can release VEGF in a controlled manner, effectively promote angiogenesis around bone defects, and provide nutritional support for new bone formation. In in vitro experiments, the composite microhydrogels had good biocompatibility. The PDA coating greatly improves cell adhesion on the composite microhydrogel and provides good controlled release of VEGF. Therefore, this composite microhydrogel effectively promotes osteogenic differentiation and vascularization. In in vivo experiments, composite microhydrogels were injected into criticalsize bone defects in the skull of rats, and they were shown by microcomputed tomography and tissue sections to be effective in promoting bone regeneration. These findings demonstrated that this novel microhydrogel effectively promotes bone formation and angiogenesis at the site of bone defects.

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“…In our previous work, biodegradable carboxymethyl chitin microspheres (CCM) were prepared and modified for hemostasis. 21,22 However, the microspheres lacked sufficient interaction with tissue and blood components, and were easily washed away by continuous blood flow due to a clotting disorder. Solid CCM with a low degree of deacetylation (8%) are also difficult to effectively modify with traditional chemical methods.…”

Section: Introductionmentioning

confidence: 99%