Modified peroxiredoxins as prototypes of drugs with powerful antioxidant action

Новоселов, В. И.; Равин, В. К.; Шарапов, М. Г.; Sofin, Alexander D.; Kukushkin, N. I.; Fesenko, E. E.

doi:10.1134/s0006350911050137

Cited by 13 publications

(4 citation statements)

References 9 publications

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“…Гистологическое исследование фрагментов миокарда в группе 2 показало большую сохранность строения ткани по сравнению с группой контроля (рис. 3,4).…”

Section: гистологическое исследование трансплантированного сердцаunclassified

“…Так как патогенез ишемически-реперфузионных повреждений (ИРП) связан с окислительным стрессом, основным направлением в терапии может стать снижение концентрации АФК в пострадавших тканях с помощью антиоксидантных препаратов [1,4].…”

Section: Introductionunclassified

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Use of peroxiredoxin for preconditioning of heterotopic heart transplantation in a rat

Grudinin

Bogdanov

Шарапов

et al. 2020

RJTAO

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Peroxiredoxin 6 (Prdx6) is an antioxidant enzyme in the human body that performs a number of important functions in the cell. Prdx6 restores a wide range of peroxide substrates, thus playing a leading role in maintaining redox homeostasis in mammalian cells. In addition to peroxidase activity, Prdx6 has an activity of phospholipase A2, thus taking part in membrane phospholipid metabolism. Due to its peroxidase and phospholipase activity, Prdx6 participates in intracellular and intercellular signal transmission, thereby facilitating the initiation of regenerative processes in the cell, suppression of apoptosis and activation of cell proliferation. Given the functions performed, Prdx6 can effectively deal with oxidative stress caused by various factors, including ischemia-reperfusion injury. On an animal model of rat heterotopic heart transplantation, we showed the cardioprotective potential of exogenous recombinant Prdx6, introduced before transplantation and subsequent reperfusion injury of the heart. It has been demonstrated that exogenous Prdx6 effectively alleviates the severity of ischemia-reperfusion injury of the heart by 2–3 times, providing normalization of its structural and functional state during heterotopic transplantation. The use of recombinant Prdx6 can be an effective approach in preventing/alleviating ischemia-reperfusion injury of the heart, as well as in maintaining an isolated heart during transplantation.

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Section: гистологическое исследование трансплантированного сердцаunclassified

Section: Introductionunclassified

Use of peroxiredoxin for preconditioning of heterotopic heart transplantation in a rat

Grudinin

Bogdanov

Шарапов

et al. 2020

RJTAO

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“…As it can be seen from Table 2, there are compounds with higher DRF values, moreover, there is a large number of compounds with comparable DRF values. However, the noticeable competitive advantage of Prdx6 over other preparations listed in Table 2 is lack of toxicity and adverse effects [112]. For example, for KGF and G-CSF, course application is supposed to be able to stimulate tumor growth [113].…”

Section: Application Of Exogenous Prdx6 As a Radioprotectormentioning

confidence: 99%

“…On the contrary, Prdx6 is a natural radioprotector and does not exert toxicity, while its efficiency is not lower than that of many known synthetic radioprotectors (Table 2). Prdx6-based preparations could be applied individually (perhaps in a complex of liposomes or perfluorocarbons) [112] or in combination with conventional modern radioprotectors from common practice, which could significantly decrease the probability of adverse effects and severity of the consequences of ionizing radiation exposure [166]. We suggest that the most promising is the application of radioprotective agents with different mechanisms of action, for example, Prdx6 as an antioxidant and indralin [97,167,168], an agent lowering oxygen consumption by the tissues, as a hypoxant, which could provide a synergistic radioprotective effect.…”

Section: Practical Aspects Of Prdx6 Radioprotective Actionmentioning

confidence: 99%

Radioprotective Role of Peroxiredoxin 6

2019

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Peroxiredoxin 6 (Prdx6) is a member of an evolutionary ancient family of peroxidase enzymes with diverse functions in the cell. Prdx6 is an important enzymatic antioxidant. It reduces a wide range of peroxide substrates in the cell, thus playing a leading role in the maintenance of the redox homeostasis in mammalian cells. Beside peroxidase activity, Prdx6 has been shown to possess an activity of phospholipase A2, an enzyme playing an important role in membrane phospholipid metabolism. Moreover, Prdx6 takes part in intercellular and intracellular signal transduction due to its peroxidase and phospholipase activity, thus facilitating the initiation of regenerative processes in the cell, suppression of apoptosis, and activation of cell proliferation. Being an effective and important antioxidant enzyme, Prdx6 plays an essential role in neutralizing oxidative stress caused by various factors, including action of ionizing radiation. Endogenous Prdx6 has been shown to possess a significant radioprotective potential in cellular and animal models. Moreover, intravenous infusion of recombinant Prdx6 to animals before irradiation at lethal or sublethal doses has shown its high radioprotective effect. Exogenous Prdx6 effectively alleviates the severeness of radiation lesions, providing normalization of the functional state of radiosensitive organs and tissues, and leads to a significant elevation of the survival rate of animals. Prdx6 can be considered as a potent and promising radioprotective agent for reducing the pathological effect of ionizing radiation on mammalian organisms. The radioprotective properties and mechanisms of radioprotective action of Prdx6 are discussed in the current review.

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