Background: In the last decade, full-endoscopic techniques to treat lumbar disc herniation (LDH) have gained popularity in clinical practice. However, few studies have described the safety and efficacy of full-endoscopic lumbar decompression (FELD) in treating older patients with LDH. The aim of this study is to evaluate the safety and efficacy of FELD and open posterior lumbar interbody fusion (O-PLIF) for stable LDH in patients over 65 years of age.Methods: Data of 251 consecutive patients over 65 years received surgical treatment for stable LDH in 2 separated groups (minimally invasive spinal surgical group and open spinal surgical group) in single center between January 2014 and April 2018 were retrospectively analyzed. Patients were categorized into 2 groups (FELD group and O-PLIF group) according to the operative procedure. Clinical outcome evaluations were performed preoperatively, at 3, 6, 12, 24 months postoperatively, including Oswestry disability index (ODI) score and Japanese orthopaedic association (JOA) score for function assessment, visual analog scale (VAS) score for low-back pain and leg pain, MacNab criteria for assessment of life quality. In addition, the surgical information, including operative time, blood loss, hospitalization time, and adverse events were assessed.Results: Among 251 patients, 153 underwent FELD and 98 underwent O-PLIF. There was no significant difference in baseline data between 2 groups (p>0.05). The mean operative time was significantly shorter, blood loss and hospitalization time were significantly reduced in patients having FELD than O-PLIF (p<0.001). The mean ODI, JOA, and VAS postoperative scores were significantly improved over the preoperative scores in both groups (p<0.05). No significant difference was between 2 groups in postoperative ODI, JOA, VAS scores, and MacNab evaluation (p>0.05). The adverse event rate was 5.2% in FELD group, which was significantly lower than that in O-PLIF group (16.3%, p<0.05). The recurrence rate was 7.2% in FELD group and the rate of adjacent segment disc herniation was 6.1% in O-PLIF group.Conclusions: FELD could achieve satisfactory safety and efficacy for the treatment of stable LDH in the patients over 65 years of age. With less trauma, faster recovery, and lower adverse event rate, FELD may be an alternative surgical treatment for stable LDH in elderly patients.