Modified Palygorskite Improves Immunity, Antioxidant Ability, Intestinal Morphology, and Barrier Function in Broiler Chickens Fed Naturally Contaminated Diet with Permitted Feed Concentrations of Fusarium Mycotoxins

Abstract

This study investigated effects of modified palygorskite (MPal) on immunity, antioxidant capacity, and intestinal barrier integrity in broiler chickens challenged with permitted feed Fusarium mycotoxin concentrations. One-day-old chicks were allocated into three treatments with eight replicates. Chickens in three groups were fed a basal diet with normal corn (control), contaminated diet containing moldy corn, with Fusarium mycotoxins contents in the diets lower than permitted feed mycotoxin concentrations, and the contaminated diet supplemented with 1 g/kg MPal for 42 days, respectively. Compared with control, moldy corn decreased bursa of Fabricius weight, jejunal secreted immunoglobulin A concentration, ileal superoxide dismutase (SOD) activity, jejunal and ileal villus height (VH) and VH/crypt depth (CD) ratio, and jejunal zonula occludens-1 and mucin 2 mRNA abundances at 42 days as well as ileal VH/CD ratio at 21 days; while they increased jejunal malondialdehyde accumulation at 21 and 42 days, jejunal SOD activity at 21 days, and serum diamine oxidase activity at 42 days, which were almost recovered by MPal. Moreover, dietary MPal upregulated ileal claudin-2 mRNA abundance compared with other two groups. The results indicated that MPal addition exerted protective effects on immunity, oxidative status, and intestinal barrier integrity in chickens challenged with permitted feed Fusarium mycotoxins levels.

Combination of Lactobacillus species and yeast ameliorates adverse effect of deoxynivalenol contaminated diet on immune system, gut morphology and jejunal gene expression in broiler chickens

“…Increasing the level of yeast in DON diet resulted in an enhancement of mucosa thickness in duodenum and ileum. The DON diet has been shown to have a detrimental effect on mucosa thickness resulting in enhancement of enteric pathogens, toxins and antigens permeability to the epithelium increasing the bird susceptibility to diseases (Cheng et al 2018). The results of our study are in accordance with previous findings of Yang et al (2019) documenting that DON contaminated diet (0.50 and 1.50 mg/kg) fed rabbits show reductions in VH, CD and ileal mucosa.…”

“…The results of our study are in accordance with previous findings of Yang et al (2019) deduced that inclusion of 1 Â 10 9 cfu/kg Lactobacillus plantarum JM113 in DON contaminated diet (10 mg/kg) increased the VH and CLDN-1 expression in Cobb broiler chickens. In another study, Cheng et al (2018) have reported that Fusarium contaminated diet decreases the VH and VH to CD in ileum and down-regulates the zona occludens-1 and MUC-2 expressions at day 42 of age confirming our results.…”

Dietary Chitooligosaccharide Inclusion as an Alternative to Antibiotics Improves Intestinal Morphology, Barrier Function, Antioxidant Capacity, and Immunity of Broilers at Early Age

“…Relative organ weight could reflect the growth and development of organs in some degree [31]. The effects of COS on relative immune organ weight have already been studied, however, the results were inconsistent.…”

Palygorskite combined probiotics improve the laying performance, hatching performance, egg quality, plasma antioxidative status, and immune response of broiler breeders

“…Palygorskite (Pal), a hydrated magnesium-rich silicate clay mineral, has the characteristics of large specific surface area, plentiful pores, and high adsorption capacity (Wang and Wang 2016). It has been reported that supplementation of Pal in the diets could ameliorate mycotoxins' toxic effects on pigs (Zhang et al 2013) and broilers (Cheng et al 2018). Besides, other researchers found that dietary supplementation with Pal could improve growth performance, antioxidant capacity, immunity, and intestinal health of animals (Schell et al 1993;Cheng et al 2016).…”