Modified magnetic-based solvent-assisted dispersive solid-phase extraction: application to the determination of cortisol and cortisone in human saliva

Grau, José; Benedé, Juan L.; Chisvert, Alberto; Salvador, Amparo

doi:10.1016/j.chroma.2021.462361

Cited by 21 publications

(5 citation statements)

References 38 publications

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“…To this end, a mixed solution of 10 ng mL −1 cortisol, cortisone and prednisolone was prepared in PBS ( pH 7.2), and then this solution was extracted with the proposed method. An LC-MS/MS method from a previous work 26 was employed for the simultaneous measurement of cortisol, cortisone and prednisolone. As can be seen in Fig.…”

Section: Analytical Performancementioning

confidence: 99%

Analysis of microsamples by miniaturized magnetic-based pipette tip microextraction: determination of free cortisol in serum and urine from very low birth weight preterm newborns

Grau

Moreno‐Guzmán

Arruza

et al. 2023

Analyst

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Section: Analytical Performancementioning

confidence: 99%

Analysis of microsamples by miniaturized magnetic-based pipette tip microextraction: determination of free cortisol in serum and urine from very low birth weight preterm newborns

Grau

Moreno‐Guzmán

Arruza

et al. 2023

Analyst

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“…In this sense, magnetic (nano)materials, frequently combining magnetic nanoparticles and polymers, have been widely used in D-μSPE due to their easy retrieval by applying an external magnetic field [51]. Miniaturized versions (usually employing centrifuge microtubes) of the different alternatives have been proposed for sample volumes below 1 ml, using either ultrasound- [52], vortex- [53,54], or solvent-assisted dispersion [55].…”

Section: Dispersive Micro-solid Phase Extractionmentioning

confidence: 99%

Ultramicroextraction as a miniaturization of the already miniaturized. A step toward nanoextraction and beyond

Azorín

Benedé

Chisvert

2023

J of Separation Science

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Miniaturization of the analytical process has been a widespread trend, and the sample preparation stage is not exempted from this downscaling. Since the introduction of microextraction techniques as miniaturization of classical extraction techniques, they have become one of the strengths in this field. However, some of the original approaches to these techniques did not fully cover all the current principles of Green Analytical Chemistry. For this reason, during the last years, much emphasis has been placed on reducing/eliminating toxic reagents, reducing the amount of the extraction phase, and searching for new greener, and more selective extractant materials. On the other hand, even though high accomplishments have been achieved, the same attention has not always been paid to reducing the amount of sample, which is essential when treating low‐availability samples such as biological samples, or in developing portable devices. In this review, we intend to give the readership an overview of the advances toward further miniaturization of microextraction techniques. Finally, a brief reflection is made on the terminology used, or that should, in our opinion, be used to term these new generation of miniaturized microextraction approaches. To this regard, the term, ‘ultramicroextraction’ is proposed to refer to those approaches beyond microextraction.

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“…Magnetic solid-phase extraction (MSPE), utilizes magnetic nanoparticles as adsorbents to recover analytes from large-volume samples under external magnetic field . Compared to other industrially relevant separation methods including LLE and SPE, the MSPE technique bypasses use of organic solvents and offers advantage in separation efficiency. , However, the selectivity of analyte retention dictated by hydrophobic interactions is often too low to satisfy the requirement of trace analysis in complex samples, especially when interfering substances arising from co-extraction and matrix effect are at high level. Therefore, a remarkable interest has been witnessed in the development of selective MSPE sorbents to afford clean-up, isolation and concentration of target compounds in a single step.…”

Section: Introductionmentioning

confidence: 99%

Magnetic Liposomes Infused with GPCR-Expressing Cell Membrane for Targeted Extraction Using Minimum Organic Solvent: An Investigative Study of Trace THC in Sewage

et al. 2023

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Trace analysis of lipophilic substances in complex environmental, food, or biological matrices has proven to be a challenge, on account of their high susceptibility to adsorption by particulate matter and liquid–solid interfaces. For this purpose, liquid–liquid extraction (LLE) is often employed as the separation method, which uses water-immiscible organic solvents. As an alternative, magnetic solid-phase extraction (MSPE) allows for adsorption, separation, and recovery of analytes from large volumes of aqueous samples with minimum usage of organic solvents. However, the poor selectivity hampers its performance in various scenarios, especially in sewage samples where complicated and unpredictable interference exists, resulting in block of the active adsorption sites of the sorbent. To this end, we propose receptor-affinity MSPE employing magnetic liposomes decorated with cell membranes expressing G-protein-coupled receptor as the sorbents. Application of the novel sorbent CM@Lip@Fe infused with CB1 cannabinoid receptors was demonstrated for the targeted extraction and enrichment of tetrahydrocannabinol from sewage matrix. Thanks to the high affinity and molecular selectivity of the ligand-receptor interactions, a limit of quantitation of 5.17 ng/L was achieved coupled with HPLC-MS/MS in unfiltered raw sewage, featuring minimum usage of organic solvents, fivefold enhanced sensitivity, low sorbent dosage (75 mg/L of sewage), and high efficiency as major advantages over conventional LLE. This work establishes a framework for efficient separation of specific molecules from complex media, thus promising to extend and refine standard LLE as the clean-up procedure for trace analysis.

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Modified magnetic-based solvent-assisted dispersive solid-phase extraction: application to the determination of cortisol and cortisone in human saliva

Cited by 21 publications

References 38 publications

Analysis of microsamples by miniaturized magnetic-based pipette tip microextraction: determination of free cortisol in serum and urine from very low birth weight preterm newborns

Analysis of microsamples by miniaturized magnetic-based pipette tip microextraction: determination of free cortisol in serum and urine from very low birth weight preterm newborns

Ultramicroextraction as a miniaturization of the already miniaturized. A step toward nanoextraction and beyond

Magnetic Liposomes Infused with GPCR-Expressing Cell Membrane for Targeted Extraction Using Minimum Organic Solvent: An Investigative Study of Trace THC in Sewage

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