Modified in vivo lung perfusion allows for prolonged perfusion without acute lung injury

Santos, Pedro Reck dos; Machuca, Tiago; Hwang, David; dePerrot, M.; Liu, Mingyao; Keshavjee, Shaf; Waddell, Thomas K.; Cypel, Marcelo

doi:10.1016/j.jtcvs.2013.10.009

Cited by 23 publications

(11 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…But in another report, an acellular perfusate and a closed left atrium resulted to a more pronounced lung edema and lower lung compliance [112], confirming a previous thought that alternative perfusion solution might contribute to lung edema formation [113]. [114], various perfusion time [115], cooling or hypothermic preservation [116], as well as alter the work flow of the transplantation, staged model to do liver-after-lung transplantation [117] and split lung transplantation in two centers with a distance of 2250 km by running EVLP [118]. The technique of EVLP-based lung split, preservation and transportation adopted in smaller children, is currently under discussion [119].…”

Section: Anti-pulmonary Edema Performancesupporting

confidence: 54%

Evolving Trend of EVLP: Advancements and Emerging Pathways

Jiao¹

2019

SN Compr. Clin. Med.

View full text Add to dashboard Cite

Lung transplant augmentation in the waiting list is impeded by donor lung shortage with a low percentage of procurement. Ex vivo lung perfusion (EVLP) was recognized to have the capacity of providing a platform to preserve, assess, recondition, and even mange existing diseases in rejected donor lungs to expand the donor pool. This review aims to provide the most advanced experimental evidence of EVLP application and perspective as a platform providing qualified donor lungs. Literature review using PubMed, Medscape, Clinical Trials, and Cochrane databases was performed. Data was collected and analyzed. From a view point of publisher, current research centers with their paper contribution volume are also presented to illustrate the future trend of EVLP academically. EVLP incubated donor lungs could have a comparable outcome with conventional transplants. Further interventional studies have shown growing interest in and expectations on EVLP platform as pathways to determine graft quality, to bridge a critical phase of the initial rejected organs and to predict prognosis or complications in an early stage. EVLP is also considered as a tissue regeneration translational research environment with multidisciplinary potential to enhance the recovery and rehabilitation after surgery and advance pulmonary medicine. Ongoing clinical trials and accelerated procedure modulation with commercialization of EVLP are leading to Bcentralization^organ preparation model, opening a new era of lifechange health innovation.

show abstract

Section: Anti-pulmonary Edema Performancesupporting

confidence: 54%

Evolving Trend of EVLP: Advancements and Emerging Pathways

Jiao¹

2019

SN Compr. Clin. Med.

View full text Add to dashboard Cite

show abstract

“…Unlike EVLP, which perfuses previously resected donor lungs, IVLP provides isolated lung perfusion to lungs that remain inside of a host. IVLP investigations have achieved this via a sternotomy or thoracotomy approach [ 22 , 64 ]. Prior to beginning the procedure, an injurious model is used to establish lung injury, which can be achieved by various protocols, including intravenous LPS, surfactant washout model, intravenous oleic acid, or gastric aspiration [ 65 , 66 ].…”

Section: Ivlp Techniquementioning

confidence: 99%

“…However, the use of IVLP to treat ARDS has utilized longer treatment (perfusion) times. In 2014, dos Santos and colleagues evaluated the use of prolonged IVLP in a large animal study, where they delivered IVLP for 4 h via a thoracotomy to six swine, followed by a 4 h reperfusion period [ 64 ]. Here, they demonstrated that using IVLP for this duration is feasible and safe, and there was no change in lung function parameters (oxygenation and compliance) or histologic evidence of acute lung injury [ 64 ].…”

Section: Investigations Of Ivlp In Ardsmentioning

confidence: 99%

Isolated Lung Perfusion in the Management of Acute Respiratory Distress Syndrome

Haywood

Byler

Zhang

et al. 2020

IJMS

View full text Add to dashboard Cite

Acute respiratory distress syndrome (ARDS) is associated with high morbidity and mortality, and current management has a dramatic impact on healthcare resource utilization. While our understanding of this disease has improved, the majority of treatment strategies remain supportive in nature and are associated with continued poor outcomes. There is a dramatic need for the development and breakthrough of new methods for the treatment of ARDS. Isolated machine lung perfusion is a promising surgical platform that has been associated with the rehabilitation of injured lungs and the induction of molecular and cellular changes in the lung, including upregulation of anti-inflammatory and regenerative pathways. Initially implemented in an ex vivo fashion to evaluate marginal donor lungs prior to transplantation, recent investigations of isolated lung perfusion have shifted in vivo and are focused on the management of ARDS. This review presents current tenants of ARDS management and isolated lung perfusion, with a focus on how ex vivo lung perfusion (EVLP) has paved the way for current investigations utilizing in vivo lung perfusion (IVLP) in the treatment of severe ARDS.

show abstract

“…This is being explored by a number of teams. 4 Another potential, and exciting application is for the treatment of adult respiratory distress syndrome, detailed in a potentially landmark article from Mehaffey and colleagues 5 in this issue of the Journal. The experiments were technically complex but conceptually simple.…”

Section: John H Dark Frcsmentioning

confidence: 99%