Modified gold and polymeric gold nanostructures: Toxicology and biomedical applications

Ullah, Muneeb; Wahab, Abdul; Khan, Dilfaraz; Saeed, Sumbul; Khan, Shahid Ullah; Ullah, Naimat; Saleh, Tawfik A.

doi:10.1016/j.colcom.2021.100412

Cited by 30 publications

(7 citation statements)

References 198 publications

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“…GNPs can be produced using numerous technologies, including chemical and physical methods that encompass various physical and chemical methods, including the template approach, sonolysis, electrochemical method, green biosynthesis method, solvent-free photochemical method, γ-irradiation method, and hot injection technique. 110,111 In most cases, the preparation of gold nanoparticles involves the use of reducing agents in conjunction with the chemical reduction of chloroauric acid (HAuCl 4 ). 112 Figure 3 shows the stages for the synthesis of GNPs.…”

Section: Synthesis Of Gnpsmentioning

confidence: 99%

Nano‐biotechnology in tumour and cancerous disease: A perspective review

Soni

Bhandari

Tripathi

et al. 2023

J Cellular Molecular Medi

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In recent years, drug manufacturers and researchers have begun to consider the nanobiotechnology approach to improve the drug delivery system for tumour and cancer diseases. In this article, we review current strategies to improve tumour and cancer drug delivery, which mainly focuses on sustaining biocompatibility, biodistribution, and active targeting. The conventional therapy using cornerstone drugs such as fludarabine, cisplatin etoposide, and paclitaxel has its own challenges especially not being able to discriminate between tumour versus normal cells which eventually led to toxicity and side effects in the patients. In contrast to the conventional approach, nanoparticle-based drug delivery provides target-specific delivery and controlled release of the drug, which provides a better therapeutic window for treatment options by focusing on the eradication of diseased cells via active targeting and sparing normal cells via passive targeting. Additionally, treatment of tumours associated with the brain is hampered by the impermeability of the blood-brain barriers to the drugs, which eventually led to poor survival in the patients. Nanoparticle-based therapy offers superior delivery of drugs to the target by breaching the blood-brain barriers. Herein, we provide an overview of the properties of nanoparticles that are crucial for nanotechnology applications. We address the potential future applications

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Section: Synthesis Of Gnpsmentioning

confidence: 99%

Nano‐biotechnology in tumour and cancerous disease: A perspective review

Soni

Bhandari

Tripathi

et al. 2023

J Cellular Molecular Medi

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show abstract

“…The layering ailments or transmittable illnesses, with photon sensitivity by the ways of photalgia intermediaries formerly is an optical maser (wavelengths connected over colorant-engrossing ideas). Remote oxygen in addition permitted free ions manufactured by photosensitizer power including tumour cell apoptosis or necrosis [ 60 , 61 ]. Au nano conjugates are easy to combine with thiols, disulphides, and amines to promote intracellular penetration [ 62 , 63 ].…”

Section: Biosensorsmentioning

confidence: 99%

Emerging application of nanotechnology for mankind

et al. 2023

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Nanotechnology has proven to be the greatest multidisciplinary field in the current years with potential applications in agriculture, pollution remediation, environmental sustainability, as well as most recently in pharmaceutical industries. As a result of its physical, chemical, and biological productivity, resistance, and matricular organization at a larger scale, the potential of nanocomposites revealed different sorts of assembling structures via testing. Biosensors are known some specifically promising inventions whereas carbon nanotube, magnetic nanoparticles (NPs), quantum dots, and gold NPs showed capability to repair damaged cells, molecular docking, drug-delivery, and nano-remediation of toxic elements. PEGylated(Poly ethyl glycol amyl gated) redox-responsive nanoscale COFs drug delivery from AgNPs and AuNPs are known to be sun blockers in sunscreen lotions. The emerging trends and yet more to be discovered to bridge the gaps forming in the field of nanotechnology, especially insights into environmental concerns and health issues most importantly the food web which is connected with the well beings of mankind to perform its tasks giving necessary results. The current review detailed emerging role of nanomaterials in human life. Supplementary Information The online version contains supplementary material available at 10.1007/s42247-023-00461-8.

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“…Nanoparticles (NPs) can be categorized according to their utilized components, such as carbon-based (fullerenes, carbon nanotubes, carbon nanodots) and inorganic nanoparticles based on metal oxides (e.g., iron oxide), metals (e.g., gold), and quantum dots (cadmium sulfide, cadmium selenide), according to Ju-Nam [148]. Metal nanoparticles are considered a milestone in the diagnosis and treatment of cancer, and among them, one of the most representative examples is the gold nanoparticles (Au-NPS) [149]. Au-NPS are often utilized as exogenous contrast agents with PAI properties due to their robust optical properties resulting from the surface plasmon resonance (SPR) effect [150].…”

Section: Combination Of Small Organic Theranostic Agents With Nanocar...mentioning

confidence: 99%

Design Principles Governing the Development of Theranostic Anticancer Agents and Their Nanoformulations with Photoacoustic Properties

et al. 2022

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The unmet need to develop novel approaches for cancer diagnosis and treatment has led to the evolution of theranostic agents, which usually include, in addition to the anticancer drug, an imaging agent based mostly on fluorescent agents. Over the past few years, a non-invasive photoacoustic imaging modality has been effectively integrated into theranostic agents. Herein, we shed light on the design principles governing the development of theranostic agents with photoacoustic properties, which can be formulated into nanocarriers to enhance their potency. Specifically, we provide an extensive analysis of their individual constituents including the imaging dyes, drugs, linkers, targeting moieties, and their formulation into nanocarriers. Along these lines, we present numerous relevant paradigms. Finally, we discuss the clinical relevance of the specific strategy, as also the limitations and future perspectives, and through this review, we envisage paving the way for the development of theranostic agents endowed with photoacoustic properties as effective anticancer medicines.

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Modified gold and polymeric gold nanostructures: Toxicology and biomedical applications

Cited by 30 publications

References 198 publications

Nano‐biotechnology in tumour and cancerous disease: A perspective review

Nano‐biotechnology in tumour and cancerous disease: A perspective review

Emerging application of nanotechnology for mankind

Design Principles Governing the Development of Theranostic Anticancer Agents and Their Nanoformulations with Photoacoustic Properties

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