Modified Glassy Carbon Electrode with Polypyrrole Nanocomposite for the Simultaneous Determination of Ascorbic acid, Dopamine, Uric acid, and Folic Acid

Abstract

A fast and simple method for synthesis of Cu x O-ZnO/PPy/RGO nanocomposite by electrochemical manner have been reported in this paper. For testing the utility of this nanocomposite we modified a GCE with the nanocomposite to yield a sensor for simultaneous determination of four analytes namely ascorbic acid (AA), dopamine (DA), uric acid (UA), and folic acid (FA). Cyclic voltammetry (CV) and Differential pulse voltammetry (DPV) selected for the study. The modified electrode cause to enhance electron transfer rate so overcome to overlapping their peaks and consequently having the ability to the simultaneous determination of AA, DA, UA, and FA. To synthesis confirmation of the nanocomposite, Field emission scanning electron microscopy (FE-SEM), Raman spectroscopy, and electrochemical impedance spectroscopy (EIS) were applied. The linearity ranges were 0.07-485 µM, 0.05-430 µM, 0.02-250 µM and 0.022-180 µM for AA, DA, UA, and FA respectively and the detection limits were 22 nM, 10 nM, 5 nM and 6 nM for AA, DA, UA, and FA respectively Also, the obtained electrode can be used for the determination of the AA, DA, UA, and FA in human blood, and human urine real samples.

Simultaneous Detection of Tartrazine-Sunset Yellow in Food Samples Using Bioxide/Carbon Paste Microcomposite with Lanthanum and Titanium

“…On the other hand, electroanalytical techniques have been a great equally sensitive alternative but with the advantage of having a low cost. Furthermore, it is a very versatile technique used to detect different types of analytes using modified electrodes such as biological substances, for example dopamine, ascorbic acid, uric acid, folic acid, guanine and glucose [23][24][25][26][27]. Also, medicaments and compounds such as ranitidine and metronidazole [28], nitric oxide [29] and hydrogen peroxide [30].…”

Molecular Imprinting Technology for Determination of Uric Acid

“…As it was mentioned above, uric acid is an electro-active compound that has oxidation potential close to +0.6 (±0.1 V) V vs. Ag/AgCl [ 10 , 12 , 52 ]. Electrochemical methods were used only for uric acid or for simultaneous determination of several target molecules including uric acid in previous studies [ 53 , 54 , 55 , 56 , 57 , 58 ]. For the discussion of interfering molecules, it should be noted that the primarily predicted purpose of the sensor, for example, for dopamine or ascorbic acid [ 59 , 60 ] or any other target molecule detection, in most cases, means the optimized conditions at which the molecules are identified as interfering and analyzed at the optimized conditions of analysis.…”

“…This principle is rather suitable if the electrochemical system is not discriminating the oxidation of analytes on the electrode. Such examples of electrochemical analysis are when the electrode is modified with Ppy, reduced graphene oxide (RGO), or graphene oxide (GO): ZnO–Cu x O/Ppy for the determination of ascorbic acid, dopamine, and uric acid [ 61 , 62 ], Cu x O-ZnO/Ppy/RGO for the determination of ascorbic acid, dopamine, uric acid, and folic acid [ 56 ], or polytetraphenylporphyrin/Ppy/GO for uric acid detection [ 62 , 63 ].…”

Ultrasensitive and Simple Dopamine Electrochemical Sensor Based on the Synergistic Effect of Cu-TCPP Frameworks and Graphene Nanosheets

“…Beyond that, electrochemical methods are attractive in the determination of DA because of their low cost, user-friendly control, fast determination, high sensitivity, and ability to enable miniaturization [ 8 , 9 ]. Many nanomaterials with different functions have been used to construct the modified electrode, such as g-C 3 N 4 /MWNTs/GO [ 10 ], Cu x O-ZnO/PPy/RGO [ 11 ], Fe 2 O 3 -NiO@GO [ 12 ], and f-MWCNTs/GO/AuNPs [ 13 ]. However, there is still much room for improvement in the electrode modification materials, for example, the simplicity, sensitivity, and selectivity.…”