Modified Glasgow Prognostic Score and Carcinoembryonic Antigen Predict Poor Prognosis in Elderly Patients with Colorectal Cancer

Numata, Koji; Ono, Yukari; Toda, Soji; Kamioka, Yuto; Suematsu, Hideaki; Sawazaki, Sho; Tsuchida, Kazuhito; Higuchi, Akio; Saeki, Hiroyuki; Rino, Yasushi; Masuda, Munetaka; Matsukawa, Hiroshi

doi:10.1159/000505930

Cited by 6 publications

(5 citation statements)

References 19 publications

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“…Various studies have shown that biomarkers such as PNI and NLR, which reflect systemic inflammation, are prognostic factors for malignancy [ 4 , 5 ]. The mGPS, derived from serum albumin and CRP levels, is among these biomarkers and is predictive of prognosis in CRC patients [ 6 ]. CAR, which is calculated from the ratio of serum albumin to CRP, has also been used as a prognostic marker.…”

Section: Discussionmentioning

confidence: 99%

“…The influence of systemic inflammation in various carcinomas has been widely reported in recent years [ 2 , 3 ]. In addition, multiple biomarkers of systemic inflammation have been developed, including the prognostic nutritional index (PNI) [ 4 ], the neutrophil to lymphocyte ratio (NLR) [ 5 ], and the modified Glasgow Prognostic Score (mGPS) [ 6 ], all of which have been reported to be related to CRC prognosis. While mGPS uses C-reactive protein (CRP) and albumin levels, CRP to albumin ratio (CAR) is a calculated value developed by Fairclough et al [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

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Clinical impact of C-reactive protein to albumin ratio of the 7th postoperative day on prognosis after laparoscopic colorectal cancer surgery

et al. 2023

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Purpose: C-reactive protein to albumin ratio (CAR) has been utilized as a prognostic factor in various carcinomas. We investigated the relationship between preoperative, postoperative day (POD) 1, and POD 7 CARs and the prognosis of patients with colorectal cancer (CRC).Methods: Three hundred twenty patients with CRC who underwent laparoscopic radical resection between May 2011 and December 2016 were enrolled. Patients were selected into 2 groups, high CAR and low CAR (n=72/group), based on preoperative, POD 1, and POD 7 CARs. The relapse-free survival (RFS) and overall survival (OS) were compared between groups using propensity score matching.Results: The high CAR group had a significantly worse RFS (P<0.001) and OS (P=0.002) at POD 7 than those in the low CAR group. However, in preoperative and POD 1 analysis, no differences were observed.Conclusion: In patients with CRC, CAR of POD 7 was a significant prognostic factor.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Clinical impact of C-reactive protein to albumin ratio of the 7th postoperative day on prognosis after laparoscopic colorectal cancer surgery

et al. 2023

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“…The modi ed Glasgow Prognostic Score (mGPS) is a validated predictive model for systemic in ammatory response (SIR), calculated based on Creactive protein (CRP) levels representing the level of in ammation and albumin levels representing the nutritional status [9]. Numerous studies have shown that increased GPS or mGPS level indicates poor prognosis in patients with mCRC, lung, oesophageal, and gastric cancers [10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Systemic inflammation plays a central role in sarcopenia and prognosis of patients with metastatic colorectal cancer: A retrospective study

Yang,

Tang,

Qiu

et al. 2023

Preprint

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Background Systemic inflammatory response (SIR) affects the prognosis of metastatic colorectal cancer (mCRC) and is reportedly a crucial triggering factor for sarcopenia. Furthermore, sarcopenia has recently been reported to be associated with shorter overall survival in patients with mCRC; however, the existing evidence is insufficient and inconsistent. Therefore, we aimed to investigate the impact of the body composition of patients on the prognosis of mCRC in relation to the SIR. Methods This retrospective study collected data from 317 patients with mCRC in China between January 2015 and 2020. The data of patients at baseline and after three cycles of first-line treatment were evaluated, primarily including modified Glasgow Prognostic Score (mGPS) [inflammation level calculated using C-reactive protein (CRP) and albumin], body composition parameters [total adipose tissue index, total adipose tissue density, skeletal muscle index (SMI), and skeletal muscle density (SMD)], and overall survival. The Kaplan–Meier survival curve was drawn to verify the predictive effect of mGPS on overall survival. Furthermore, non-parametric tests and the empirical cumulative distribution function were used to evaluate the relationship between mGPS and body composition and univariate and multivariate Cox regression analysis was used to determine the factors related to the prognosis of mCRC. Results In our cohort, the survival curve showed that the baseline mGPS had a strong predictive effect on overall survival. The empirical cumulative distribution function showed that a high mGPS level was associated with a low baseline SMD and SMI and a low SMI after treatment, indicating a significant correlation between sarcopenia and mGPS. Univariate analysis showed that factors affecting prognosis included CRP, albumin, mGPS, and specific body compositions. In multivariate analysis, only mGPS retained independent prognostic value, and a high baseline mGPS level indicated poor prognosis. Conclusions Regarding SIR, we found that body composition and overall survival were affected in patients with mCRC, and sarcopenia and poor prognosis had no direct causal relationship. Furthermore, mGPS was found to be a simple and effective prognostic factor; therefore, it should be monitored during treatment. These findings could help clinicians formulate effective individualised anti-inflammatory strategies and improve the prognosis of mCRC.

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“…Additionally, elderly patients often present with different clinical features, including a greater proportion of advanced-stage disease at diagnosis, and a higher prevalence of comorbidities [ 5 ]. Last but not least, elderly patients with CRC undergoing surgery are more likely to have a poor prognosis and survival rates than younger patients [ 6 , 7 ]. Thus, it is necessary to identify new prognostic markers and explore the potential mechanism of poor prognosis in elderly patients with CRC, thereby improving their survival and leading to better management and treatment of the disease.…”

Section: Introductionmentioning

confidence: 99%

Construction of a novel nomogram based on competing endogenous RNAs and tumor-infiltrating immune cells for prognosis prediction in elderly patients with colorectal cancer

Tao

Kang³

et al. 2023

Discov Onc

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Competitive endogenous RNAs (ceRNAs) and tumor-infiltrating immune cells play essential roles in colorectal cancer (CRC) tumorigenesis. However, their prognostic role in elderly patients with CRC is unclear. Gene expression profiles and clinical information for elderly patients with CRC were downloaded from The Cancer Genome Atlas. Univariate, LASSO, and multivariate Cox regression analyses were utilized for screening key ceRNAs and prevent overfitting. A total of 265 elderly patients with CRC were included. We constructed a novel ceRNA network consisting of 17 lncRNAs, 35 miRNAs, and 5 mRNAs. We established three prognosis predictive nomograms based on four key ceRNAs (ceRNA nomogram), five key immune cells (immune cell nomogram), and their combination (ceRNA-immune cell nomogram). Among them, the ceRNA-immune cell nomogram had the best accuracy. Furthermore, the areas under the curve of the ceRNA-immune cell nomogram were also significantly greater than the TNM stage at 1 (0.818 vs. 0.693), 3 (0.865 vs. 0.674), and 5 (0.832 vs. 0.627) years. Co-expression analysis revealed that CBX6 was positively correlated with activated dendritic cells (R = 0.45, p < 0.01), whereas negatively correlated with activated mast cells (R =− 0.43, p < 0.01). In conclusion, our study constructed three nomograms to predict prognosis in elderly patients with CRC, among which the ceRNA-immune cell nomogram had the best prediction accuracy. We inferred that the mechanism underlying the regulation of activated dendritic cells and mast cells by CBX6 might play a crucial role in tumor development and prognosis of elderly patients with CRC.

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Modified Glasgow Prognostic Score and Carcinoembryonic Antigen Predict Poor Prognosis in Elderly Patients with Colorectal Cancer

Cited by 6 publications

References 19 publications

Clinical impact of C-reactive protein to albumin ratio of the 7th postoperative day on prognosis after laparoscopic colorectal cancer surgery

Clinical impact of C-reactive protein to albumin ratio of the 7th postoperative day on prognosis after laparoscopic colorectal cancer surgery

Systemic inflammation plays a central role in sarcopenia and prognosis of patients with metastatic colorectal cancer: A retrospective study

Construction of a novel nomogram based on competing endogenous RNAs and tumor-infiltrating immune cells for prognosis prediction in elderly patients with colorectal cancer

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