Modified fractal analysis of methionine positron emission tomography images for predicting prognosis in newly diagnosed patients with glioma

Nakajima, Reiko; Nagao, Michinobu; Ohashi, Ryoko; Muragakı, Yoshihiro; Nitta, Masayuki; Maruyama, Takashi; Komori, Takashi; Abe, Koichiro; Kawamata, Takakazu; Sakai, Shuji

doi:10.1097/mnm.0000000000000917

Cited by 2 publications

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“…To date, only the study of Nakajima et al has published results using fractal analysis of MET PET according to the glioma grade [9]. They observed no significant differences between the fractal dimension and gliomas of any grade [9]. One of the reasons for this discrepancy may be differences in the histological types of gliomas.…”

Section: Discussionmentioning

confidence: 99%

“…However, in this study, similar to SUV analysis, even fractal analysis was unable to distinguish between IDH1-wildtype diffuse astrocytoma and anaplastic astrocytoma and glioblastoma. To date, only the study of Nakajima et al has published results using fractal analysis of MET PET according to the glioma grade [9]. They observed no significant differences between the fractal dimension and gliomas of any grade [9].…”

Section: Discussionmentioning

confidence: 99%

“…Miwa et al demonstrated that fractal analysis using 2-deoxy-2-[ 18 F]fluorod-glucose (FDG) PET is useful for discriminating benign from malignant pulmonary nodules [8]. Nakajima and colleagues evaluated modified fractal analysis of MET PET for predicting prognosis in patients with newly diagnosed gliomas [9]. In their study, modified fractal dimension was significantly associated with a poor prognosis [9].…”

mentioning

confidence: 99%

“…Nakajima and colleagues evaluated modified fractal analysis of MET PET for predicting prognosis in patients with newly diagnosed gliomas [9]. In their study, modified fractal dimension was significantly associated with a poor prognosis [9]. However, the experience with PET fractal analysis is still limited.…”

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Fractal analysis of 11C-methionine PET in patients with newly diagnosed glioma

et al. 2021

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Background The present study tested the possible utility of fractal analysis from l-[methyl-11C]-methionine (MET) uptake in patients with newly diagnosed gliomas for differentiating glioma, especially in relation to isocitrate dehydrogenase 1 (IDH1) mutation status, and as compared with the conventional standardized uptake value (SUV) parameters. Methods Investigations of MET PET/CT were performed retrospectively in 47 patients with newly diagnosed glioma. Tumors were divided into three groups: lower grade glioma (IDH1-mutant diffuse astrocytoma and IDH1-mutant anaplastic astrocytoma), higher grade glioma (IDH1-wildtype diffuse astrocytoma and IDH1-wildtype anaplastic astrocytoma), and glioblastoma. The fractal dimension for tumor, maximum SUV (SUVmax) for tumor (T) and mean SUV for normal contralateral hemisphere (N) were calculated, and the tumor-to-normal (T/N) ratio was determined. Metabolic tumor volume (MTV) and total lesion MET uptake (TLMU) were also measured. Results There were significant differences in SUVmax (p = 0.006) and T/N ratio (p = 0.02) between lower grade glioma and glioblastoma. There were no significant differences among any of the three groups in MTV or TLMU. Significant differences were obtained in the fractal dimension between lower grade glioma and higher grade glioma (p = 0.006) and glioblastoma (p < 0.001). Conclusions The results of this preliminary study in a small patient population suggest that the fractal dimension using MET PET in patients with newly diagnosed gliomas is useful for differentiating glioma, especially in relation to IDH1 mutation status, which has not been possible with SUV parameters.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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