Modified drug release of poloxamer matrix by including water-soluble and water-insoluble polymer

Gonzalez, Y. M.; Ghaly, Evone S.

doi:10.3109/03639040903061363

Cited by 6 publications

(11 citation statements)

References 15 publications

(14 reference statements)

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“…These findings are consistent with previous research, as outlined in the literature section, which demonstrates that an increased concentration of P-407 in formulations consistently leads to delayed drug release across various types of dosage forms [ 33 , 56 , 76 ]. For instance, Zhang et al developed a topical CR formulation containing ceftiofur for foot infections.…”

Section: Discussionsupporting

confidence: 92%

“…This swelling process forms a gel-like barrier around the formulation. Concurrently or subsequently, the polymer undergoes dissolution, further contributing to the CR dynamics [ 56 , 74 ]. Gel formation within this matrix system is initiated by the hydration and subsequent swelling of the hydrophilic chains of P-407, accompanied by the aggregation of hydrophobic components to minimize their contact with the aqueous media.…”

Section: Discussionmentioning

confidence: 99%

“…As a result, a more pronounced delay in drug release is observed. Additionally, the enhanced hydrophobic chain effect further limits water diffusion into the matrix system, reinforcing the CR mechanism [ 56 ].…”

Section: Discussionmentioning

confidence: 99%

“…For this, the CRMS-F15 capsules were stored in a stability chamber (Binder, Bohemia, NY, USA) set to these specific conditions. The formulation’s stability was determined by assessing in vitro drug release and drug content after 72 h [ 56 ]. A third batch was stored at a constant temperature of 20 °C and a humidity level of 25%.…”

Section: Materials and Methodologymentioning

confidence: 99%

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Preparation and Characterization of Theophylline Controlled Release Matrix System Incorporating Poloxamer 407, Stearyl Alcohol, and Hydroxypropyl Methylcellulose: A Novel Formulation and Development Study

Sakkal,

Arafat,

Yuvaraju

et al. 2024

Polymers

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Background: Theophylline (THN), a bronchodilator with potential applications in emerging conditions like COVID-19, requires a controlled-release delivery system due to its narrow therapeutic range and short half-life. This need is particularly crucial as some existing formulations demonstrate impaired functionality. This study aims to develop a new 12-h controlled-release matrix system (CRMS) in the form of a capsule to optimize dosing intervals. Methods: CRMSs were developed using varying proportions of poloxamer 407 (P-407), stearyl alcohol (STA), and hydroxypropyl methylcellulose (HPMC) through the fusion technique. Their in vitro dissolution profiles were then compared with an FDA-approved THN drug across different pH media. The candidate formulation underwent characterization using X-ray diffraction, scanning electron microscopy, Fourier transform infrared spectroscopy, differential scanning calorimetry, and thermogravimetric analysis. Additionally, a comprehensive stability study was conducted. Results: In vitro studies showed that adjusting the concentrations of excipients effectively controlled drug release. Notably, the CRMS formulation 15 (CRMS-F15), which was composed of 30% P-407, 30% STA, and 10% HPMC, closely matched the 12 h controlled-release profile of an FDA-approved drug across various pH media. Characterization techniques verified the successful dispersion of the drug within the matrix. Furthermore, CRMS-F15 maintained a consistent controlled drug release and demonstrated stability under a range of storage conditions. Conclusions: The newly developed CRMS-F15 achieved a 12 h controlled release, comparable to its FDA-approved counterpart.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Materials and Methodologymentioning

confidence: 99%

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Preparation and Characterization of Theophylline Controlled Release Matrix System Incorporating Poloxamer 407, Stearyl Alcohol, and Hydroxypropyl Methylcellulose: A Novel Formulation and Development Study

Sakkal,

Arafat,

Yuvaraju

et al. 2024

Polymers

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“…Because HPMC K4M (A) and LBG (C) has sufficient cohesiveness and fibrous integrity makes them to undergo binding and contributed for hardness [26]. …”

Section: Resultsmentioning

confidence: 99%

Natural gums as sustained release carriers: development of gastroretentive drug delivery system of ziprasidone HCl

Hn²,

Sb³

2012

DARU J Pharm Sci

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BackgroundObjective of this study is to show the potential use of natural gums in the development of drug delivery systems. Therefore in this work gastro retentive tablet formulations of ziprasidone HCl were developed using simplex lattice design considering concentration of okra gum, locust bean gum and HPMC K4M as independent variables. A response surface plot and multiple regression equations were used to evaluate the effect of independent variables on hardness, flag time, floating time and drug release for 1 h, 2 h, and 8 h and for 24 h. A checkpoint batch was also prepared by considering the constraints and desirability of optimized formulation to improve its in vitro performance. Significance of result was analyzed using ANOVA and p < 0.05 was considered statistically significant.ResultsFormulation chiefly contains locust bean gum found to be favorable for hardness and floatability but combined effect of three variables was responsible for the sustained release of drug. The in vitro drug release data of check point batch (F8) was found to be sustained well compared to the most satisfactory formulation (F7) of 7 runs. The ‘n’ value was found to be between 0.5 and 1 suggesting that release of drug follows anomalous (non-fickian) diffusion mechanism indicating both diffusion and erosion mechanism from these natural gums. Predicted results were almost similar to the observed experimental values indicating the accuracy of the design. In vivo floatability test indicated non adherence to the gastric mucosa and tablets remain buoyant for more than 24 h.ConclusionsStudy showed these eco-friendly natural gums can be considered as promising SR polymers.

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Disorders in Pharmaceutical Polymers

Dudognon

2016

Disordered Pharmaceutical Materials

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This chapter discusses the performance and applications of pharmaceutical polymers in relation to their structure and degree of disorder. It first gives an overview of the main characteristics of polymers in terms of their architecture, physical states, and mobility. The chapter highlights the different origins and types of disorders that can be found in polymers, namely structural disorders and dynamic disorders. Pharmaceutical polymers are widely used in solid dosage forms such as drug/excipient amorphous solid dispersions, which are mixtures of polymers and low molecular weight (MW) drugs. The chapter particularly focuses on the influence of drug incorporation on the polymer mobility and the issues of the limits of polymer-drug miscibility and solubility. Finally, it discusses the relationship between the disorder and the physical properties and behavior of pharmaceutical polymers when used in solid dosage forms through a few illustrative examples involving the most widely used polymers

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Modified drug release of poloxamer matrix by including water-soluble and water-insoluble polymer

Abstract: These results suggest that the combination of poloxamer 407 with hypromellose or carbomer is feasible and has potential to offer the formulator control over drug release.

Cited by 6 publications

References 15 publications

Preparation and Characterization of Theophylline Controlled Release Matrix System Incorporating Poloxamer 407, Stearyl Alcohol, and Hydroxypropyl Methylcellulose: A Novel Formulation and Development Study

Preparation and Characterization of Theophylline Controlled Release Matrix System Incorporating Poloxamer 407, Stearyl Alcohol, and Hydroxypropyl Methylcellulose: A Novel Formulation and Development Study

Natural gums as sustained release carriers: development of gastroretentive drug delivery system of ziprasidone HCl

Disorders in Pharmaceutical Polymers

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