Modified Dipeptide-Based Nanoparticles: Vehicles for Targeted Tumor Drug Delivery

Panda, Jiban Jyoti; Kaul, Ankur; Kumar, Santosh; Alam, Md. Sayem; Mishra, Anil K.; Kundu, Gopal C.; Chauhan, Virander S.

doi:10.2217/nnm.12.201

Cited by 33 publications

(38 citation statements)

References 53 publications

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“…Loading capacity of, and the release of miRNA from its complex with RΔF‐LA NPs indicated their suitability as possible delivery agent for miRNA. The ability of any NPs based delivery systems to protect their cargos including oligonucleotides in in vivo enzymatic conditions is an important prerequisite parameter for their potential use in clinical applications . Results of stability experiment showed that miR‐199a‐3p was stable in serum as well as to the action of RNase A.…”

Section: Discussionmentioning

confidence: 99%

“…Our study paves the way for future investigations using a large cohort of mice and testing a range of doses of RΔF‐LA/miR NPs for therapeutic potency. It may also be possible to deliver both miRNA and an anticancer drug simultaneously to the tumor site using this peptide based NPs …”

Section: Discussionmentioning

confidence: 99%

“…It may also be possible to deliver both miRNA and an anticancer drug simultaneously to the tumor site using this peptide based NPs. (38)…”

Section: Discussionmentioning

confidence: 99%

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Targeted delivery of microRNA‐199a‐3p using self‐assembled dipeptide nanoparticles efficiently reduces hepatocellular carcinoma in mice

et al. 2018

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Targeted delivery of microRNA‐199a‐3p using self‐assembled dipeptide nanoparticles efficiently reduces hepatocellular carcinoma in mice

et al. 2018

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“…Here, we report spontaneous self-assembly of a dipeptide, Leucine-α, β-dehydrophenylalanine, containing a non-protein amino acid, α,β-dehydrophenylalanine (ΔPhe) at its C-terminal, into a highly stable hydrogel under physiological conditions. ΔPhe is an analogue of phenylalanine, with a double bond between C α and C β atoms, whose incorporation in peptide sequences introduces conformational constraint in the peptide backbone and provides increased resistance to enzymatic degradation 8 9 10 . The hydrogel formed by LeuΔPhe was translucent, self-supportive, fractaline in nature, of high mechanical strength, non-toxic, injectable, proteolytically stable and responsive to external stimuli like ionic strength, pH and temperature.…”

mentioning

confidence: 99%

“A novel highly stable and injectable hydrogel based on a conformationally restricted ultrashort peptide”

Thota

Yadav

Chauhan

2016

Sci Rep

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Nanostructures including hydrogels based on peptides containing non protein amino acids are being considered as platform for drug delivery because of their inherent biocompatibility and additional proteolytic stability. Here we describe instantaneous self-assembly of a conformationally restricted dipeptide, LeuΔPhe, containing an α,β-dehydrophenylalanine residue into a highly stable and mechanically strong hydrogel, under mild physiological aqueous conditions. The gel successfully entrapped several hydrophobic and hydrophilic drug molecules and released them in a controlled manner. LeuΔPhe was highly biocompatible and easily injectable. Administration of an antineoplastic drug entrapped in the gel in tumor bearing mice significantly controlled growth of tumors. These characteristics make LeuΔPhe an attractive candidate for further development as a delivery platform for various biomedical applications.

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“…The spontaneous self-assembly of a dipeptide, Leucine-α,βdehydrophenylalanine, containing a non-protein amino acid, α,β-dehydrophenylalanine (ΔPhe) at its C-terminal, into a highly stable hydrogel under physiological conditions. ΔPhe is an analogue of phenylalanine, with a double bond between Cα and Cβ atoms, whose incorporation in peptide sequences introduces conformational restriction in the peptide backbone and provides increased resistance to enzymatic degradation [ 25 , 26 ]. The hydrogel designed by LeuΔPhe was transparent, self-supportive, fractaline in nature, of high mechanical strength, non-toxic, injectable, proteolytically stable and responsive to external stimuli, such as ionic strength, pH and temperature.…”

Section: Introductionmentioning

confidence: 99%

A Review on Recent Advances in Stabilizing Peptides/Proteins upon Fabrication in Hydrogels from Biodegradable Polymers

et al. 2018

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Hydrogels evolved as an outstanding carrier material for local and controlled drug delivery that tend to overcome the shortcomings of old conventional dosage forms for small drugs (NSAIDS) and large peptides and proteins. The aqueous swellable and crosslinked polymeric network structure of hydrogels is composed of various natural, synthetic and semisynthetic biodegradable polymers. Hydrogels have remarkable properties of functionality, reversibility, sterilizability, and biocompatibility. All these dynamic properties of hydrogels have increased the interest in their use as a carrier for peptides and proteins to be released slowly in a sustained manner. Peptide and proteins are remarkable therapeutic agents in today’s world that allow the treatment of severe, chronic and life-threatening diseases, such as diabetes, rheumatoid arthritis, hepatitis. Despite few limitations, hydrogels provide fine tuning of proteins and peptides delivery with enormous impact in clinical medicine. Novels drug delivery systems composed of smart peptides and molecules have the ability to drive self-assembly and form hydrogels at physiological pH. These hydrogels are significantly important for biological and medical fields. The primary objective of this article is to review current issues concerned with the therapeutic peptides and proteins and impact of remarkable properties of hydrogels on these therapeutic agents. Different routes for pharmaceutical peptides and proteins and superiority over other drugs candidates are presented. Recent advances based on various approaches like self-assembly of peptides and small molecules to form novel hydrogels are also discussed. The article will also review the literature concerning the classification of hydrogels on a different basis, polymers used, “release mechanisms” their physical and chemical characteristics and diverse applications.

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Modified Dipeptide-Based Nanoparticles: Vehicles for Targeted Tumor Drug Delivery

Cited by 33 publications

References 53 publications

Targeted delivery of microRNA‐199a‐3p using self‐assembled dipeptide nanoparticles efficiently reduces hepatocellular carcinoma in mice

Targeted delivery of microRNA‐199a‐3p using self‐assembled dipeptide nanoparticles efficiently reduces hepatocellular carcinoma in mice

“A novel highly stable and injectable hydrogel based on a conformationally restricted ultrashort peptide”

A Review on Recent Advances in Stabilizing Peptides/Proteins upon Fabrication in Hydrogels from Biodegradable Polymers

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