In this article, the performance of quadrature amplitude modulation (QAM)-based single-and double-stage digital interpolators have been compared. The basic interpolator for up-sampling can be a combination of an expander unit with an interpolation lowpass filter in cascade. Complicated implementations can be done by connecting multiple expander and low-pass filter pairs in cascade. This article presents the efficient and effective implementation of digital interpolation systems for up-sampling of single-and double-stage digital interpolators. Comparison is done in terms of spectrum of generated signal, envelope power, modulated signal trajectory, input and output constellation and noise performance. In this article, the proposed interpolation filters have been simulated in Agilent's Advanced Design System (ADS).