Modified chitosan coated mesoporous strontium hydroxyapatite nanorods as drug carriers

Abstract

ARTICLE This journal isMesoporous strontium hydroxyapatite (SrHAp) nanorods (NRs) have been successfully synthesized using a simple and efficient chemical route, i.e. the hydrothermal method. A structural and morphological characterization of the as synthesized SrHAp NRs has been performed by transmission electron microscopy (TEM) and high angle annular dark field scanning transmission electron microscopy (HAADF-STEM). TEM and HAADF-STEM measurements of the NRs reveal the coexistence of longer and shorter particles with a length ranging from 50nm to 400nm and a diameter of about 20-40nm. Electron tomography measurements of the NRs allow us to better visualize the mesopores and their facets. Two model drugs, Risperdone as hydrophobic and Pramipexole as hydrophilic, were loaded into the SrHAp NRs. These nanorods were coated using a modified chitosan (CS) with poly(2-hydroxyethyl methacrylate) (PHEMA), in order to encapsulate the drug-loaded SrHAp nanoparticles and to reduce the cytotoxicity of the loaded materials. The drug release from neat and encapsulated SrHAp NRs mainly depends on the drug hydrophilicity. Importantly, although neat SrHAp nanorods exhibit some cytotoxicity against Caco-2 cells, the Cs-g-PHEMA-SrHAp drug-loaded nanorods show an acceptable cytocompatibility.

High‐Performance Flexible Supercapacitors Based on Ionogel Electrolyte with an Enhanced Ionic Conductivity

“…Figure S5). The data coincides well with the parent poly‐HEMA network with a similar amorphous nature. To further understand the crystalline nature of the ionogel electrolytes, DSC measurements were performed.…”

Design and characterization of nanocarriers loaded with Levofloxacin for enhanced antimicrobial activity; physicochemical properties, in vitro release and oral acute toxicity

“…Similarly to a previous work (Filippousi et al, 2015), 200 mg of LVF was dissolved in 200 ml of Page 3 / 13 Acetonitrile/Methanol (ACN/MeOH) (10/90). Then, 200 mg of SBA, CNTs and HNTs were added to the drug solution.…”

“…The band at 2980 and 2898 cm -1 is assigned to asymmetric stretching vibrations of ν(CH 2 ). When LVF was absorbed an altered spectrum was seen due to possible interaction between LVF and the nanotubes (Filippousi et al, 2015). Moreover, the broad band at 3489 cm -1 corresponds to a higher absorbance because of LVF presence.…”

“…It is reported that incorporating a hydrophilic drug onto Page 7 / 13 nanomaterials, porous or not, a slower release rate can be achieved. Nonetheless, in almost all cases a burst effect is accomplished (Filippousi et al, 2016;Filippousi et al, 2015).…”

Recent trends on hydrogel based drug delivery systems for infectious diseases

“…Nanomedicine actively target locations by the use of various NFs 14 as a DDS which include nanoparticles, 8 polymeric micelles, 15, 16 nanorods, 17, 18 nanospheres, 19, 20 solid lipid nanoparticles, 21, 22 nanolipososmes, 23, 24 dendrimers, 25, 26 metal nanoparticles 27, 28 , fullerenes and quantum dots. 29, 30 These NFs have been useful in the development of the various different routes like systemic, oral, pulmonary, transdermal and have been helpful for the drug targeting and On-demand drug delivery techniques.…”