Modified Bu-Fei decoction inhibits lung metastasis via suppressing angiopoietin-like 4

Hao, Huifeng; Guo, Zhengwang; Li, Zhandong; Li, Junfeng; Jiang, Shantong; Fu, Jialei; Jiao, Yanna; Deng, Xiaowei; Han, Shuyu; Li, Pingping

doi:10.1016/j.phymed.2022.154409

Search citation statements

Order By: Relevance

Paper Sections

Select...

Natural Products1

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2022

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

(1 citation statement)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Jinfukang is a traditional Chinese medicine prescription for lung cancer treatment; it inhibits the integrin/Src pathway, suppressing ECM-receptor interaction and focal adhesion-related genes [173]. Modified Bu-Fei decoction inhibits hypoxia-inducible factor 1α (HIF-1α) signaling and angiogenin-like protein 4 (ANGPTL4) to inhibit A549 cells anoikis and lung metastasis of LLC-bearing mice [174].…”

Section: Natural Productsmentioning

confidence: 99%

Anoikis-Associated Lung Cancer Metastasis: Mechanisms and Therapies

Wang

Luo

Lin

et al. 2022

Cancers

View full text Add to dashboard Cite

Tumor metastasis occurs in lung cancer, resulting in tumor progression and therapy failure. Anoikis is a mechanism of apoptosis that combats tumor metastasis; it inhibits the escape of tumor cells from the native extracellular matrix to other organs. Deciphering the regulators and mechanisms of anoikis in cancer metastasis is urgently needed to treat lung cancer. Several natural and synthetic products exhibit the pro-anoikis potential in lung cancer cells and in vivo models. These products include artonin E, imperatorin, oroxylin A, lupalbigenin, sulforaphane, renieramycin M, avicequinone B, and carbenoxolone. This review summarizes the current understanding of the molecular mechanisms of anoikis regulation and relevant regulators involved in lung cancer metastasis and discusses the therapeutic potential of targeting anoikis in the treatment of lung cancer metastasis.

show abstract

Section: Natural Productsmentioning

confidence: 99%