Modified Brain Stem Auditory Evoked Potentials in Patients With Intracranial Mass Lesions

Stone, James L.; Fino, John J.; Patel, Ketan; Calderon-Arnulphi, Mateo; Suss, Nichole; Hughes, John R.

doi:10.1177/1550059412452688

Cited by 4 publications

(2 citation statements)

References 41 publications

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“…The click BAEP waves P1, P3, and P5 absolute latencies, but not IPLs (P1–3, 3–5, or 1–5), are significantly increased with age, indicating a peripheral rather than brainstem origin of the absolute latency delay (Stone et al, 2009). On the other hand, BAEPs are sensitive to brainstem lesions from tumor, metabolic disorders, and vascular dysfunction (Davis et al, 1985;Drake, Jr. et al, 1990;Sand et al, 2008;Stone et al, 2012). BAEPs are also used for intraoperative monitoring during surgery in the brainstem area (Acioly et al, 2010), and can indicate coma prognosis (Balogh et al, 2001).…”

Section: Discussionmentioning

confidence: 99%

Altered brainstem auditory evoked potentials in a rat central sensitization model are similar to those in migraine

Arakaki¹,

Galbraith²,

Pikov³

et al. 2014

Brain Research

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Migraine symptoms often include auditory discomfort. Nitroglycerin (NTG)-triggered central sensitization (CS) provides a rodent model of migraine, but auditory brainstem pathways have not yet been studied in this example. Our objective was to examine brainstem auditory evoked potentials (BAEPs) in rat CS as a measure of possible auditory abnormalities. We used four subdermal electrodes to record horizontal (h) and vertical (v) dipole channel BAEPs before and after injection of NTG or saline. We measured the peak latencies (PLs), interpeak latencies (IPLs), and amplitudes for detectable waveforms evoked by 8, 16, or 32 KHz auditory stimulation. At 8 KHz stimulation, vertical channel positive PLs of waves 4, 5, and 6 (vP4, vP5, and vP6), and related IPLs from earlier negative or positive peaks (vN1-vP4, vN1-vP5, vN1-vP6; vP3-vP4, vP3-vP6) increased significantly 2 hours after NTG injection compared to the saline group. However, BAEP peak amplitudes at all frequencies, PLs and IPLs from the horizontal channel at all frequencies, and the vertical channel stimulated at 16 and 32 KHz showed no significant/consistent change. For the first time in the rat CS model, we show that BAEP PLs and IPLs ranging from putative bilateral medial superior olivary nuclei (P4) to the more rostral structures such as the medial geniculate body (P6) were prolonged 2 hours after NTG administration. These BAEP alterations could reflect changes in neurotransmitters and/or hypoperfusion in the midbrain. The similarity of our results with previous human studies further validates the rodent CS model for future migraine research.

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Section: Discussionmentioning

confidence: 99%

Altered brainstem auditory evoked potentials in a rat central sensitization model are similar to those in migraine

Arakaki¹,

Galbraith²,

Pikov³

et al. 2014

Brain Research

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“…False-positive and false-negative results of BAEP monitoring are explained by anesthesia, hypothermia, ear problems, as well as surgical manipulations not involving the auditory pathways and nuclei [16,26,115,119,118].…”

Section: Monitoring Cn VIIImentioning

confidence: 99%

Neurophysiological Monitoring during Surgery on the Central Nervous System: The Role of Evoked Responses

Soghomonyan

2015

IJAR

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Neurosurgical, orthopedic and vascular interventions may be associated with an inherent risk of ischemia and structural damage to the central nervous system. Along with other modalities used to monitor the intraoperative nervous function, registration of evoked responses is intended to provide real-time feedback about the functional integrity of the central nervous system and help to prevent avoidable trauma during surgery. In this review, the principal indications and limitations of monitoring various evoked responses during surgery on the brain and spinal cord are discussed. Current approaches, recent advances and problems associated with intraoperative rhomboid fossa mapping, cranial nerve stimulation and electrooculographic monitoring are presented as well. The authors discuss the effects of general anesthesia on evoked responses and possible ways to avoid signal variability during registration. It is emphasized that only with close cooperation between neurosurgeons, anesthesiologists and neurophysiologists it will be possible to maximize the benefits of intraoperative monitoring of evoked responses and avoid misinterpretation of the results.

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Neurophysiologische Untersuchungen

Lütschg¹

2018

Pädiatrische Neurochirurgie

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Modified Brain Stem Auditory Evoked Potentials in Patients With Intracranial Mass Lesions

Cited by 4 publications

References 41 publications

Altered brainstem auditory evoked potentials in a rat central sensitization model are similar to those in migraine

Altered brainstem auditory evoked potentials in a rat central sensitization model are similar to those in migraine

Neurophysiological Monitoring during Surgery on the Central Nervous System: The Role of Evoked Responses

Neurophysiologische Untersuchungen

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