Modified bowel preparation regimen for use in second‐generation colon capsule endoscopy in patients with ulcerative colitis

Usui, Shingo; Hosoe, Naoki; Matsuoka, Katsuyoshi; Taku, Keisei; Nakano, Masaaki; Ishibashi, Yuji; Kimura, Kazuhiro; Yoneno, Kazuaki; Kashiwagi, Kazuhiro; Hisamatsu, Tadakazu; Inoue, Nagamu; Shinmoto, Hiroshi; Hibi, Toshifumi; Ogata, Haruhiko; Kanai, Takanori

doi:10.1111/den.12269

Cited by 24 publications

(22 citation statements)

References 28 publications

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“…[111][112][113] In available CE systems, RAPID software (Given Imaging, Ltd) has been installed in the flexible spectral imaging color enhancement system, raising the possibility of improving the contrast of vascular and mucosal patterns. 113,114 Aihara et al 112 and we reported 111 enhanced visibility of prototype small-bowel CE equipped with whitelight light-emitting diodes selected specifically to increase Table 3 Modified bowel preparation for ulcerative colitis (reproduced from Usui et al 99 )…”

Section: Future Perspectivesmentioning

confidence: 88%

“…In patients without contraindications, sodium phosphate solution is recommended as a booster. In Japan, sodium phosphate solution is not available, and magnesium citrate is used instead . To improve patient acceptance, Hartmann et al .…”

Section: Colon Cementioning

confidence: 99%

“…In Japan, sodium phosphate solution is not available, and magnesium citrate is used instead. 98,99 To improve patient acceptance, Hartmann et al 97 reduced the preparation to 2.75 L PEG plus ascorbic acid for colorectal cancer screening. Kakugawa et al 98 also used a reduced regimen with 2 L PEG and 1.8 L magnesium citrate (3.8 L total).…”

Section: Colon Cementioning

confidence: 99%

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Current status of capsule endoscopy through a whole digestive tract

Hosoe

Ogata

2014

Digestive Endoscopy

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More than a decade has passed since small-bowel capsule endoscopy (CE) was first reported. Small-bowel CE is a non-invasive tool that allows visualization of the entire small-intestinal mucosa and facilitates detection of small-intestinal abnormalities. Several studies have shown benefit of small-bowel CE for certain disorders. Because it is non-invasive, CE has been applied to other organs including the esophagus, stomach, and colon. The main indications for esophageal CE (ECE) are screening for gastroesophageal reflux disease/Barrett's esophagus, and esophageal varices. However, the clinical benefit of ECE is unconfirmed. Magnetically guided CE (MGCE) was developed to visualize the gastric mucosa. MGCE is a new concept with room for improvement of capsule navigation and the preparation protocol. Recently, two new small-bowel CE tools were released. First-generation colon CE (CCE-1) has moderate sensitivity and specificity compared with colonoscopy for colorectal neoplasia surveillance. To obtain higher accuracy, a second-generation CCE (CCE-2) was developed with a high sensitivity for detecting clinically relevant polypoid lesions. A possible application of CCE is for inflammatory bowel disease. In the near future, CE may include diagnostic and therapeutic functions such as magnifying endoscopy systems, targeted biopsy forceps, and drug delivery systems.

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Section: Future Perspectivesmentioning

confidence: 88%

Section: Colon Cementioning

confidence: 99%

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Current status of capsule endoscopy through a whole digestive tract

Hosoe

Ogata

2014

Digestive Endoscopy

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“…Compared with NaP-based regimens, the completion rate is lower, yet the application of PEG as booster is still promising for its safety and further studies should be performed to evaluate how completion rate may be increased. Previously, magnesium citrate was applied as an emerging booster with completion rates of 55-85% (23,24). These fluctuating results emphasize the need for further research on magnesium citrate as a booster.…”

Section: Discussionmentioning

confidence: 99%

Feasibility of a novel low-volume and sodium phosphate-free bowel preparation regimen for colon capsule endoscopy

Zhou

Tang

Wang

et al. 2017

Experimental and Therapeutic Medicine

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Abstract. Bowel preparation regimens for colon capsule endoscopy are not yet standardized since they are not well optimized. The aim of the present study was to evaluate the feasibility of a novel low-volume and sodium phosphate-free bowel preparation regimen for colon capsule endoscopy. A total of 31 patients were prospectively enrolled. In the novel regimen, on the day prior to examination, a low-fiber diet was permitted, 5 mg mosapride citrate was administered twice (1 h prior to lunch and supper) and 1 l polyethylene glycol was administered in the evening. On the day of the examination, an additional 1 l polyethylene glycol, 5 mg mosapride citrate and 200 mg simethicone were administered before capsule ingestion. Polyethylene glycol booster (0.5 l) was administered twice, at 1 and 4 h following capsule ingestion. Colon cleansing levels, ileocecal valve transit time and completion rate were evaluated. A total of 29 patients were included in the final analysis, 90% of whom achieved adequate preparation of the overall colon. Ileocecal valve transit time was 2.35±0.82 h and completion rate was 79.3%. The results revealed that the novel low-volume and sodium phosphate-free bowel preparation regimen for colon capsule endoscopy was feasible, with adequate colon cleansing and completion rates, and has the potential to be used as an alternative regimen. IntroductionColorectal cancer (CRC) is the second most common type of cancer in western countries and has exhibited an increasing incidence in many Asian countries in recent decades (1,2). A recent study demonstrated that screening for CRC in average-risk adults was effective in reducing the mortality rate (3). A satisfactory screening method for CRC must be safe, non-invasive, cost-effective, easily acceptable and possess a high diagnostic accuracy (4).The PillCam colon capsule endoscopy (CCE) may achieve direct visualization of the entire colon without sedation, radiation or air insufflation, which represents a non-invasive imaging system for exploring the colon (5). Although colonoscopy is currently considered to be the gold standard method for CRC screening and the diagnosis of most colonic diseases (4), the PillCam colon capsule endoscopy has been developed as the most promising approach to CRC screening in recent years, which is an alternative for patients with incomplete colonoscopy or who are reluctant to accept colonoscopy examination due to discomfort or embarrassment (6).The effectiveness of CCE partly depends on the cleanliness of the colon. An optimal bowel preparation regimen for CCE is required for a clean intestine, capsule propulsion and visualization of the whole large intestine. Previous studies have demonstrated bowel preparation regimens for CCE that generally consist of a split-dosage of polyethylene glycol (PEG) with the volume of 4 l, prokinetic agents and sodium phosphate (NaP) boosters (5,7-9). However, large volumes of laxatives may reduce patient compliance. Furthermore, NaP is associated with certain adverse events, such as electrolyte dis...

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“…Moreover, sodium phosphate solution can potentially cause aphthoid ulcers or active colitis that can mimic IBD. Hence, some studies used PEG‐only regimen, magnesium citrate as boost, or the use of ascorbic acid and Gastrografin. On the other hand, Hartmann et al .…”

Section: Bowel Preparation For Cce In Ibdmentioning

confidence: 99%

Colon capsule endoscopy for inflammatory bowel disease

Jiao

Leung

2018

J of Digest Diseases

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Colon capsule endoscopy (CCE) is designed for direct visualization of the colonic mucosa through passive propulsion. The role of CCE in the detection of colonic polyps has been extensively evaluated. As mucosal healing has emerged as a pivotal target for treatment of inflammatory bowel disease (IBD), there is increasing data to suggest that CCE can also be used in the monitoring of mucosal inflammation in patients with active IBD, particularly in ulcerative colitis (UC) and Crohn's disease (CD). Despite advantages such as its non-invasive nature, patient's comfort, safety, and access to anatomical regions not easily reached by conventional endoscopy, CE has limitations including the lack of ability to obtain biopsies or therapeutic capabilities and no control over movement. In this review, the role and diagnostic value of CCE on diagnosis and monitoring of UC and CD patients, its safety and limitations are discussed.

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Modified bowel preparation regimen for use in second‐generation colon capsule endoscopy in patients with ulcerative colitis

Abstract: Using CCE-2, the modified bowel preparation regimen, with reduced volume has the potential to succeed in the evaluation of mucosal severity in UC.

Cited by 24 publications

References 28 publications

Current status of capsule endoscopy through a whole digestive tract

Current status of capsule endoscopy through a whole digestive tract

Feasibility of a novel low-volume and sodium phosphate-free bowel preparation regimen for colon capsule endoscopy

Colon capsule endoscopy for inflammatory bowel disease

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