2004
DOI: 10.1016/j.atherosclerosis.2004.03.020
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Modified atherogenic lipoproteins induce expression of pentraxin-3 by human vascular smooth muscle cells

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Cited by 147 publications
(125 citation statements)
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“…Moreover, it associates to the extracellular matrix and interacts with biologically active molecules, such as fibroblast growth factor-2, for which it behaves as an inhibitor (3). PTX3 is produced by vessel cells in response to cytokines and to oxidized low-density lipoprotein (4,5) and is expressed in atherosclerotic lesions (4,(6)(7)(8). PTX3 levels are high in diseases characterized by persistent vascular inflammation, including systemic small vessel vasculitis (9)(10)(11) and chronic heart failure (12,13).…”
mentioning
confidence: 99%
“…Moreover, it associates to the extracellular matrix and interacts with biologically active molecules, such as fibroblast growth factor-2, for which it behaves as an inhibitor (3). PTX3 is produced by vessel cells in response to cytokines and to oxidized low-density lipoprotein (4,5) and is expressed in atherosclerotic lesions (4,(6)(7)(8). PTX3 levels are high in diseases characterized by persistent vascular inflammation, including systemic small vessel vasculitis (9)(10)(11) and chronic heart failure (12,13).…”
mentioning
confidence: 99%
“…Recently, PTX3, a pentraxin, was identified as an inflammatory protein 13) . Some reports have revealed that, in humans, PTX3 is produced in areas of atherosclerosis and may contribute to the pathogenesis of atherosclerosis 16,33,34) . It has been shown that endothelial cells, macrophages and smooth muscle cells involved in atherosclerosis produce PTX3 16,35) ; therefore, levels of PTX3 may directly indicate the status of vascular inflammation.…”
Section: Discussionmentioning
confidence: 99%
“…27,28 Moreover, several studies demonstrated that PTX3 is induced in vascular smooth muscle cells by atherogenic-modified low-density lipoprotein and is present in atherosclerotic lesions. 27,29 PTX3 inhibits FGF2-dependent activation of smooth muscle cells. 30 Therefore, it could be said that PTX3 plays a role in the defense mechanism of CVD.…”
Section: Discussionmentioning
confidence: 99%