1976
DOI: 10.1016/0022-2836(76)90282-5
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Modifications to histones immediately after synthesis

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Cited by 203 publications
(131 citation statements)
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“…This pattern closely resembles that of acetylation of lysine 56 on newly synthesized H3 prior to chromatin assembly (15), suggesting that the S-phase peak of H3 Lys-9 acetylation that we observed also reflects the acetylation of newly synthesized H3. The fact that the H3 lysine 9 acetylation levels go down after S-phase indicates for the first time that the deposition-specific acetylation on the N-terminal tail of H3 is removed following replication-dependent chromatin assembly, as is the case for the deposition-specific acetylation marks on the N terminus of histone H4 (11). In contrast to the wild type cells, the peak of S-phase-specific H3 lysine 9 acetylation was absent from the asf1⌬ cells (Fig.…”
Section: Resultsmentioning
confidence: 99%
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“…This pattern closely resembles that of acetylation of lysine 56 on newly synthesized H3 prior to chromatin assembly (15), suggesting that the S-phase peak of H3 Lys-9 acetylation that we observed also reflects the acetylation of newly synthesized H3. The fact that the H3 lysine 9 acetylation levels go down after S-phase indicates for the first time that the deposition-specific acetylation on the N-terminal tail of H3 is removed following replication-dependent chromatin assembly, as is the case for the deposition-specific acetylation marks on the N terminus of histone H4 (11). In contrast to the wild type cells, the peak of S-phase-specific H3 lysine 9 acetylation was absent from the asf1⌬ cells (Fig.…”
Section: Resultsmentioning
confidence: 99%
“…The N-terminal tails of the newly synthesized histones H3 and H4 are characteristically modified on specific residues prior to their deposition onto DNA and are termed deposition-specific modifications. For example, new histone H4 is generally acetylated on lysines 5 and 12 (10), but following deposition onto the DNA, the newly synthesized H4 is deacetylated over the next 30 -60 min (11), which is required for proper chromatin maturation (12). Newly synthesized histone H3 is also acetylated, although the target residues and pattern of acetylation vary between species.…”
mentioning
confidence: 99%
“…The acetylation of the N-terminal tails of newly synthesized histones is turned over very rapidly in human cells (4,5). Therefore, the apparent absence of H3 Lys-56 acetylation in human cells could merely reflect technical limitations in detecting the small fraction of total histones that carry the modification.…”
Section: Discussionmentioning
confidence: 99%
“…Lysine acetylation on histones is best characterized for its role in transcriptional regulation, but evidence for a crucial function during replication and DNA damage tolerance is accumulating (1)(2)(3). Indeed, newly synthesized histones that are deposited throughout the genome during replication are transiently acetylated at several lysine residues (4,5). These include sites of acetylation in the N-terminal tails of both histones H3 and H4 (6 -8).…”
mentioning
confidence: 99%
“…Histone acetylation is catalyzed by histone acetyltransferases (HATs), a group of enzymes that transfer the acetyl group from the cofactor acetyl-Coenzyme A (acetyl-CoA) to the ε-amino group of lysine residues on histones (Marmorstein and Roth, 2001;Roth et al, 2001;Carrozza et al, 2003;Marmorstein, 2004). It was discovered years ago that newly-synthesized histones were acetylated and rapidly deacetylated following deposition (Ruiz-Carrillo et al, 1975;Jackson et al, 1976). It is only recently that we have begun to appreciate the function of acetylated newly-synthesized H3-H4.…”
Section: Multiple Acetylation Events Regulate Assembly Of Newly-synthmentioning
confidence: 99%