Modifications of the antioxidant enzymes in relation to chromosome imbalances in human melanoma cell lines

Bravard, Anne; Cherbonnel, Corinne; Reillaudou, M; Beaumatin, Jacqueline; Dutrillaux, Bernard; Luccioni, C.

doi:10.1097/00008390-199808000-00006

Cited by 12 publications

(2 citation statements)

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“…Additionally, polymorphisms in this gene have been associated with cancer (60). Some evidence from in vitro studies suggests that superoxide dismutase 2 may act as a tumor suppression gene (61)(62)(63)(64)(65), with increased expression of superoxide dismutase 2 having been shown to suppress the cancer phenotype in a large number of mammalian tumor cells, including human melanoma cells (61,62). We observed down-regulated expression of superoxide dismutase 2 in individuals with skin lesions, which may indicate an increased vulnerability to reactive oxygen species generated by arsenic in individuals with manifest arsenic toxicity.…”

Section: Discussionmentioning

confidence: 99%

Gene Expression Profiles in Peripheral Lymphocytes by Arsenic Exposure and Skin Lesion Status in a Bangladeshi Population

Argos¹,

Kibriya²,

Parvez

et al. 2006

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Millions of individuals worldwide are chronically exposed to arsenic through their drinking water. In this study, the effect of arsenic exposure and arsenical skin lesion status on genome-wide gene expression patterns was evaluated using RNA from peripheral blood lymphocytes of individuals selected from the Health Effects of Arsenic Longitudinal Study. Affymetrix HG-U133A GeneChip (Affymetrix, Santa Clara, CA) arrays were used to measure the expression of f22,000 transcripts. Our primary statistical analysis involved identifying differentially expressed genes between participants with and without arsenical skin lesions based on the significance analysis of microarrays statistic with an a priori defined 1% false discovery rate to minimize false positives. To better characterize differential expression, we also conducted Gene Ontology and pathway comparisons in addition to the gene-specific analyses. Fourhundred sixty-eight genes were differentially expressed between these two groups, from which 312 differentially expressed genes were identified by restricting the analysis to female never-smokers. We also explored possible differential gene expression by arsenic exposure levels among individuals without manifest arsenical skin lesions; however, no differentially expressed genes could be identified from this comparison. Our findings show that microarray-based gene expression analysis is a powerful method to characterize the molecular profile of arsenic exposure and arsenic-induced diseases. Genes identified from this analysis may provide insights into the underlying processes of arsenic-induced disease and represent potential targets for chemoprevention studies to reduce arsenicinduced skin cancer in this population.

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Section: Discussionmentioning

confidence: 99%

Gene Expression Profiles in Peripheral Lymphocytes by Arsenic Exposure and Skin Lesion Status in a Bangladeshi Population

Argos¹,

Kibriya²,

Parvez

et al. 2006

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…Many preclinical studies have demonstrated that melanoma cells are particularly susceptible to increases in ROS compared with melanocytes [11-14]. This observed redox sensitivity is likely attributable to i) elevated antioxidant capacity in melanocytes, able to efficiently counteract oxidative insult compared with melanoma cells (which may have antioxidant gene mutations [15-17]) and ii) the metabolic requirement for and sensitivity to chronically elevated ROS levels for maintenance of oncogenic signaling [18]. A proposed model for the basis of this selective sensitivity of melanoma cells to ROS-generating therapeutic agents is summarized in Figure 1.…”

Section: Role Of Ros In Melanomamentioning

confidence: 99%

Autophagy: In the cROSshairs of cancer

Hambright

Ghosh

2017

Biochemical Pharmacology

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Two prominent features of tumors that contribute to oncogenic survival signaling are redox disruption, or oxidative stress phenotype, and high autophagy signaling, making both phenomena ideal therapeutic targets. However, the relationship between redox disruption and autophagy signaling is not well characterized and the clinical impact of reactive oxygen species (ROS)-generating chemotherapeutics on autophagy merits immediate attention as autophagy largely contributes to chemotherapeutic resistance. In this commentary we focus on melanoma, using it as an example to provide clarity to current literature regarding the roles of autophagy and redox signaling which can be applicable to initiation and maintenance of most tumor types. Further, we address the crosstalk between ROS and autophagy signaling during pharmacological intervention and cell fate decisions. We attempt to elucidate the role of autophagy in regulating cell fate following treatment with ROS-generating agents in preclinical and clinical settings and discuss the emerging role of autophagy in cell fate decisions and as a cell death mechanism. We also address technical aspects of redox and autophagy evaluation in experimental design and data interpretation. Lastly, we present a provocative view of the clinical relevance, emerging challenges in dual targeting of redox and autophagy pathways for therapy, and the future directions to be addressed in order to advance both basic and translational aspects of this field.

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The Adventures of Superoxide Dismutase in Health and Disease: Superoxide in the Balance

Powers

Oberley

Domann

2008

Oxidants in Biology

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Modifications of the antioxidant enzymes in relation to chromosome imbalances in human melanoma cell lines

Cited by 12 publications

References 0 publications

Gene Expression Profiles in Peripheral Lymphocytes by Arsenic Exposure and Skin Lesion Status in a Bangladeshi Population

Gene Expression Profiles in Peripheral Lymphocytes by Arsenic Exposure and Skin Lesion Status in a Bangladeshi Population

Autophagy: In the cROSshairs of cancer

The Adventures of Superoxide Dismutase in Health and Disease: Superoxide in the Balance

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