Modifications of perineuronal nets and remodelling of excitatory and inhibitory afferents during vestibular compensation in the adult mouse

Faralli, Alessio; Dagna, Federico; Albera, Andrea; Bekku, Yoko; Oohashi, Toshitaka; Albera, Roberto; Rossi, Ferdinando; Carulli, Daniela

doi:10.1007/s00429-015-1095-7

Cited by 21 publications

(19 citation statements)

References 90 publications

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“…Expression of PNNs in the brain, including the DCN, has been previously shown to be reduced following enriched environmental stimulation (32, 50), locomotion training (51), injury (47,52,53), or drug exposure (54)(55)(56). Our study shows a change in PNN expression during learning of new associations.…”

Section: Discussionsupporting

confidence: 59%

Cerebellar plasticity and associative memories are controlled by perineuronal nets

Carulli

Broersen

Winter

et al. 2020

Proc. Natl. Acad. Sci. U.S.A.

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Perineuronal nets (PNNs) are assemblies of extracellular matrix molecules, which surround the cell body and dendrites of many types of neuron and regulate neural plasticity. PNNs are prominently expressed around neurons of the deep cerebellar nuclei (DCN), but their role in adult cerebellar plasticity and behavior is far from clear. Here we show that PNNs in the mouse DCN are diminished during eyeblink conditioning (EBC), a form of associative motor learning that depends on DCN plasticity. When memories are fully acquired, PNNs are restored. Enzymatic digestion of PNNs in the DCN improves EBC learning, but intact PNNs are necessary for memory retention. At the structural level, PNN removal induces significant synaptic rearrangements in vivo, resulting in increased inhibition of DCN baseline activity in awake behaving mice. Together, these results demonstrate that PNNs are critical players in the regulation of cerebellar circuitry and function.

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Section: Discussionsupporting

confidence: 59%

Cerebellar plasticity and associative memories are controlled by perineuronal nets

Carulli

Broersen

Winter

et al. 2020

Proc. Natl. Acad. Sci. U.S.A.

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“…In addition, creation of PNNs seems to be directly involved in closing the critical period in barrel cortex (McRae et al, 2007; Nowicka et al, 2009). Furthermore, damage to the peripheral vestibular labyrinth of adult rats causes PNN reduction in the lateral vestibular nuclei of the brainstem in conjunction with remodeling of afferents, followed by restoration of PNNs when vestibular compensation is complete (Faralli et al, 2016). In that study it was shown that PNNs break down over the first 3 to 6 days, and have recovered significantly by day 12 and completely by day 24 (Faralli et al, 2016).…”

Section: Hyaluronanmentioning

confidence: 99%

Brain extracellular space, hyaluronan, and the prevention of epileptic seizures

Perkins

Arranz

Yamaguchi

et al. 2017

Reviews in the Neurosciences

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“…Breakdown of nets produces unwanted sprouting of synapses and changes in the balance of excitatory and inhibitory neuronal transmission. For instance, parallel plastic changes of excitatory and inhibitory synaptic transporters of vesicular glutamergic transporter 1 (VGLUT1), VGLUT2 and vesicular GABAergic transporter (VGAT), as well as changes in PNN densities, were observed during vestibular compensation 9 .…”

Section: Introductionmentioning

confidence: 99%

Neuronal and perineuronal changes of cerebral cortex after exposure to inhaled particulate matter

Kim

Lee

Park

et al. 2019

Sci Rep

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The inhalation of particulate matter (PM) increases the perineuronal nets (PNNs) in the cerebral cortex; however, little is known about the related molecular changes. We explored how PM exposure impacted cognitive function and the levels of PNN-related genes. BALB/c mice (6-week-old females, n = 32) were exposed to 1–5-μm diesel-extracted particles (DEPs) (100 µg/m3, 5 hours per day, 5 days per week) and categorized into the following four groups: 1) 4-week DEP exposure (n = 8); 2) 4-week control (n = 8); 3) 8-week DEP exposure (n = 8); and 4) 8-week control (n = 8). The Y-maze test and olfactory function test were conducted after 4 and 8 weeks of DEP exposure. The prefrontal cortex, olfactory bulb and temporal cortex were harvested from the animals in each group. The expression of genes related to PNNs (Tenascin C, matrix metalloproteinase [MMP]14, MMP9) and synaptic vesicular transporters of vesicular glutamergic transporter 1 (VGLUT1), VGLUT2, vesicular GABAergic transporter (VGAT) were measured. The temporal cortex was immunostained for neurocan, VGLUT1, and VGAT. The 4-week DEP group had lower total arm entry in the Y-maze test and olfactory sensitivity. These impaired behavioral functions recovered in the 8-week DEP group. Expression of tenascin C and MMP9 were increased in the cerebral cortex in the 8-week DEP group compared with the control group. The levels of VGLUT1, VGLUT2, and VGAT were elevated in the cerebral cortex of the 8-week DEP group compared with the control group. In immunostaining of the temporal cortex, the expression of neurocan, VGLUT1, and GAD67 were increased in the 8-week DEP group compared with the control group. The 4-week DEP inhalation impaired spatial activities and olfactory sensitivities. After 8 weeks of DEP exposure, the PNN components and their proteolytic enzymes and the vesicular transporters increased in the cerebral cortex.

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Modifications of perineuronal nets and remodelling of excitatory and inhibitory afferents during vestibular compensation in the adult mouse

Cited by 21 publications

References 90 publications

Cerebellar plasticity and associative memories are controlled by perineuronal nets

Cerebellar plasticity and associative memories are controlled by perineuronal nets

Brain extracellular space, hyaluronan, and the prevention of epileptic seizures

Neuronal and perineuronal changes of cerebral cortex after exposure to inhaled particulate matter

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