Modifications in tissue histamine levels in mast cell-deficient mice (W/Wv) and in their littermates (Wv/+, W/+ and +/+) grafted with a methylcholanthrene-induced fibrosarcoma: correlation with tumour rejection

Ponvert, C.; Galoppin, L.; Canu, P.

doi:10.1016/0304-3835(94)90248-8

Cited by 4 publications

(1 citation statement)

References 42 publications

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“…This high tumor occurrence was decreased to the normal intensity once MC deficiency had been defeated. Additionally, tumor occurrence and progression were inversely correlated with MC density (MCD) in the organs of MC-depleted, partially MC-depleted, and MC-sufficient mice [23,24]. In a study assessing increase in pulmonary metastases of B16 melanoma; lung metastases were considerably diminished in controls when compared to MC-free (W/Wv) mice [25].…”

Section: Mast Cells In Tumor Tissuementioning

confidence: 99%

Mast Cells and their Role in Inflammatory and Tumor Tissues

Özdemir¹

2017

MOJI

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Mast cells are multifunctional cells and they can also have a role as effector factors of the human innate and adaptive immune system. While a number of researchers still assume Mast cells to be augmenters of tumor growth, particularly via their effects on neoplastic angiogenesis; growing clinical and laboratory information also signify that Mast Cells could hamper tumor development. This inhibitory or promoting effect of Mast cells on tumor expansion seems to be depending on numerous relations among Mast cell, tumor cell type and the tumor stroma. Further in vitro and in vivo researches are required to elucidate more the interactions among Mast cells, tumor tissue and other inflammatory cells.

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Section: Mast Cells In Tumor Tissuementioning

confidence: 99%