Modifications hémodynamiques induites par le test d'apnée chez le patient en état de mort cérébrale

Apnea testing for the diagnosis of brain death

“…There was a raise by 10 mmHg which correlated with an increase in PaCO 2 (and a drop in pH). This effect is reversible and not deleterious for right ventricular function (66). We have most often noted a mild increase in systemic BP during hyperxoygenation and a decrease with hypercarbia (50).…”

Low-flow ECCO2R conjoined with renal replacement therapy platform to manage pulmonary vascular dysfunction with refractory hypercapnia in ARDS

“…Low tidal volumes are more commonly used nowadays to provide pulmonary protective ventilation though often give rise to hypercapnia in the majority of ARDS patients [ 23 ]. Hypercapnia can exacerbate hypoxic vasoconstriction [ 24 , 25 ] and can also directly induce vasoconstriction of the pulmonary vasculature, as shown in experimental animals [ 26 , 27 ], young healthy volunteers [ 28 ], brain-dead patients subjected to apnea tests [ 29 ], cardiac-surgery patients [ 30 ], and patients with ARDS [ 31 , 32 ]. Patients with cor pulmonale exhibited higher PaCO 2 levels as compared to their counterparts in all published clinical studies assessing RV function by echocardiography during ARDS [ 11 , 13 , 33 , 34 ].…”