Modification to dietary intake of sodium, potassium, calcium, magnesium and trace elements can influence arachidonic acid metabolism and eicosanoid production

Peplow, P.V.

doi:10.1016/0952-3278(92)90097-3

Cited by 10 publications

(8 citation statements)

References 183 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Se is known to influence critical immune cell functions and has been shown to affect antibody production, cell proliferation, cytokine production, eicosanoid metabolism, and neutrophil function [38][39][40][41][42]. However, very little is known about the influence of Se nutrition on the interaction of these cells with EC.…”

Section: Discussionmentioning

confidence: 99%

Increased neutrophil adherence and adhesion molecule mRNA expression in endothelial cells during selenium deficiency

Maddox

Aherne

Reddy

et al. 1999

Journal of Leukocyte Biology

View full text Add to dashboard Cite

Leukocyte aggregation and activation on endothelial cells (EC) are important preliminary events in leukocyte migration into tissue and subsequent inflammation. Thus, an increase in leukocyte adherence has the potential to affect inflammatory disease outcome. Selenium (Se) is an integral part of the antioxidant enzyme glutathione peroxidase (GSH-Px) and plays an important role in the maintenance of the redox state of a cell. Se supplementation in the bovine has been shown to improve the outcome of acute mastitis caused by coliform bacteria, in part by enhancing the speed of neutrophil migration into the affected mammary gland. However, the mechanisms by which Se modulates neutrophil migration have not been elucidated. Therefore, an in vitro model of Se deficiency in primary bovine mammary artery EC was used to examine the impact of Se status on the adhesive properties of EC. The effect of Se on functional activities was examined by measuring neutrophil adherence to Se-deficient and Se-supplemented EC. Se-deficient EC showed significantly enhanced neutrophil adherence when stimulated with tumor necrosis factor ␣ (TNF-␣) for 4 or 24 h, interleukin-1 for 12 h, or H 2 O 2 for 20 min (P F 0.05). To determine the mechanisms underlying these changes in neutrophil adherence, the expression of EC adhesion molecules, ICAM-1, E-selectin, and P-selectin were examined at the molecular level by a competitive reverse transcription-polymerase chain reaction. Results revealed higher mRNA expression for Eselectin and ICAM-1 in Se-deficient EC stimulated with TNF-␣ for 3 and 6 h, and greater expression of P-selectin mRNA in Se-supplemented EC with 3-h TNF-␣ stimulation. These studies provide new information to establish the role of Se nutrition in the initiation of leukocyte adherence to endothelium.

show abstract

Section: Discussionmentioning

confidence: 99%

Increased neutrophil adherence and adhesion molecule mRNA expression in endothelial cells during selenium deficiency

Maddox

Aherne

Reddy

et al. 1999

Journal of Leukocyte Biology

View full text Add to dashboard Cite

show abstract

“…Long-term melatonin administration reduced hyper-insulinemia and improved the altered fatty-acid compositions in type 2 diabetic rats via the restoration of Δ 5 activity, indicating that melatonin can modulate essential fatty acid metabolism [ 112 ]. The influence of minerals and trace elements on AA metabolism and eicosanoid production is complex [ 19 ]. Selenium, an important component of the Se-dependent enzyme glutathione peroxidase (Se-GSHpx), functions synergistically with vitamin E as an antioxidant and thus may prevent lipid peroxidation and alter the production of eicosanoids.…”

Section: Antioxidants Phytochemicals Vitamins and Mineralsmentioning

confidence: 99%

“…It is noteworthy that LA is oxidized to form oxidized LA metabolites (OXLAMs) that are the most abundant oxidized fatty acids in oxidized low density lipoprotein, which are potentially more atherogenic than unmodified low density lipoprotein. This implies that various factors that have a modulatory influence on LA metabolism such as antioxidants [ 9 – 12 ], phytochemicals [ 13 – 18 ], minerals [ 19 ], gender [ 20 , 21 ], age [ 22 ], and genetics [ 23 ] play a significant role in bringing about its (LA) beneficial action. Thus, there are many variables that modulate the metabolism of various fatty acids.…”

Section: Introductionmentioning

confidence: 99%

State of the art paper Potential role of dietary lipids in the prophylaxis of some clinical conditions

Bhagat¹,

Das²

2015

aoms

View full text Add to dashboard Cite

An imbalance of dietary lipids may potentially have a significant role in the pathobiology of some chronic diseases. Public health dietary fat recommendations have emphasized that low saturated fat, high monounsaturated fat, and high polyunsaturated fat with a lower ω-6 to ω-3 fatty acid ratio intake are necessary for normal health. However, such universal recommendations are likely to be hazardous, since the outcome of recommended lipid intake may depend on the consumption of other important dietary constituents that have an important role in the metabolism of lipids. In addition, consumption of fatty acids as per the individually tailored specific requirements in the context of other nutritional factors may have the potential to stabilize hormones, mood and sleep, and minimize adverse events. In support of this proposal, we review various factors that influence fatty acid metabolism, which need to be taken into consideration for appropriate utilization and consequently prevention of various diseases.

show abstract

“…Non-immunogenic surveillance performed by N K cells also require Mg2+ ions. Magnesium-dependent tumor cytolysis requires T-lymphocytes, macrophages and neutro phils and forms activated species of oxygen [3,4].…”

Section: Introductionmentioning

confidence: 99%

“…Elevation of magnesium levels in solid tumors is observed, when it is monitored with its simultaneous depletion in the surrounding healthy tissues. Magnesium is involved, therefore, in both carcinogenic and anti-carcinogenic activi ties [4,6].…”

Section: Introductionmentioning

confidence: 99%

Antitumoral Effect of Bleomycin + Dolomite Combination Treatment, in Mice Bearing Ehrlich Ascites Carcinoma

Scheller

Król

Skirmuntt

et al. 1993

Zeitschrift Für Naturforschung C

View full text Add to dashboard Cite

Dolomite, a mineral composed of magnesium and cal cium carbonates, potentiates the antitumoral activity of bleomycin: While 40 days after inoculation, no mice sur vived the Ehrlich ascites tumor burden, 44% of them survived it after bleomycin treatment, and 63% after a simultaneous treatment of bleomycin and dolomite. The beneficial antitumor effect of dolomite is probably relat ed to its high content ( 12.8%) of magnesium.

show abstract

Modification to dietary intake of sodium, potassium, calcium, magnesium and trace elements can influence arachidonic acid metabolism and eicosanoid production

Cited by 10 publications

References 183 publications

Increased neutrophil adherence and adhesion molecule mRNA expression in endothelial cells during selenium deficiency

Increased neutrophil adherence and adhesion molecule mRNA expression in endothelial cells during selenium deficiency

State of the art paper Potential role of dietary lipids in the prophylaxis of some clinical conditions

Antitumoral Effect of Bleomycin + Dolomite Combination Treatment, in Mice Bearing Ehrlich Ascites Carcinoma

Contact Info

Product

Resources

About