Modification par l'érythromycine et un extrait de Lactobacillus acidophilus de la colonisation de l'intestin et de la translocation de Campylobacter jejuni chez la souris axénique

Moyen, E.; Bonneville, Françoise; Fauchère, Jean-Louis

doi:10.1016/s0769-2609(86)80024-2

Cited by 16 publications

(4 citation statements)

References 10 publications

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“…Competition for adhesion sites at th gastrointestinal level has been described between heat-killed cells/purified structures from Lactobacillus and gastrointestinal pathogens, such as diarrheagenic E. coli (ETEC) [111], Campylobacter [112], and H. pylori [59,89].…”

Section: Effects Of Probiotics As Heat-killed Bacteriamentioning

confidence: 99%

Health Benefits of Heat-Killed (Tyndallized) Probiotics: An Overview

Piqué

Berlanga

Miñana-Galbis

2019

IJMS

371

284

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Nowadays, the oral use of probiotics is widespread. However, the safety profile with the use of live probiotics is still a matter of debate. Main risks include: Cases of systemic infections due to translocation, particularly in vulnerable patients and pediatric populations; acquisition of antibiotic resistance genes; or interference with gut colonization in neonates. To avoid these risks, there is an increasing interest in non-viable microorganisms or microbial cell extracts to be used as probiotics, mainly heat-killed (including tyndallized) probiotic bacteria (lactic acid bacteria and bifidobacteria). Heat-treated probiotic cells, cell-free supernatants, and purified key components are able to confer beneficial effects, mainly immunomodulatory effects, protection against enteropathogens, and maintenance of intestinal barrier integrity. At the clinical level, products containing tyndallized probiotic strains have had a role in gastrointestinal diseases, including bloating and infantile coli—in combination with mucosal protectors—and diarrhea. Heat-inactivated probiotics could also have a role in the management of dermatological or respiratory allergic diseases. The reviewed data indicate that heat-killed bacteria or their fractions or purified components have key probiotic effects, with advantages versus live probiotics (mainly their safety profile), positioning them as interesting strategies for the management of common prevalent conditions in a wide variety of patients´ characteristics.

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Section: Effects Of Probiotics As Heat-killed Bacteriamentioning

confidence: 99%

Health Benefits of Heat-Killed (Tyndallized) Probiotics: An Overview

Piqué

Berlanga

Miñana-Galbis

2019

IJMS

371

284

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“…This substance, excreted by the L. acidophilus LB in LB‐SCS, is effective against a large variety of Gram‐positive and Gram‐negative enterovirulent bacteria but does not show any inhibitory activity against microflora bacteria such as Bifidobacterium or Lactobacillus. All these mechanisms are not altered by heat treatment (9–11).…”

Section: Discussionmentioning

confidence: 99%

“…In these cellular models, the presence of heat‐killed L. acidophilus LB and fermented culture medium (also named spent culture supernatant: LB‐SCS) inhibit adhesion to and invasion of enterocytes by microorganisms responsible for diarrhea (9). In vivo, administration of heat‐killed L. acidophilus LB inhibits systemic spread of Campylobacter jejuni from the gastrointestinal tract (10). Second, L. acidophilus LB produce antimicrobial agent(s), probably containing a nonconventional acidic amino acid (11).…”

Section: Discussionmentioning

confidence: 99%

Clinical Evaluation of the Addition of Lyophilized, Heat‐Killed Lactobacillus acidophilus LB to Oral Rehydration Therapy in the Treatment of Acute Diarrhea in Children

Simakachorn,

Pichaipat,

Rithipornpaisarn

et al. 2000

J. pediatr. gastroenterol. nutr.

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Background:Addition of a medication to the World Health Organization protocol for treatment of acute diarrhea in children is controversial. In this trial, the clinical efficacy of a medication (Lactéol Fort sachets; Laboratoire du Lactéol du Docteur Boucard, Houdan France) containing lyophilized heat‐killed Lactobacillus acidophilus LB was assessed as an adjunct to oral rehydration therapy.Methods:Children aged 3 to 24 months with acute diarrhea and mild or moderate dehydration were enrolled in the study. Children received oral rehydration therapy for the first 4 hours. After this first rehydration phase, undiluted milk formula or breast milk was fed alternately with oral rehydration solution. Children were fed rice gruel as tolerated. They received either one sachet containing 10 billion of lyophilized heat‐killed L. acidophilus LB or placebo at admission and at 12‐hour intervals for five doses.Results:Seventy‐three children (37 L. acidophilus LB, 36 placebo) were enrolled, of whom 40 (17 L. acidophilus LB, 23 placebo) received an antibiotic before inclusion. Rotavirus was identified in approximately 50% of the children in each group. After 24 hours of treatment, the number of rotavirus‐positive children with watery stools was significantly lower (p = 0.012) in the L. acidophilus LB group. Mean duration of diarrhea was decreased (p = 0.034) with L. acidophilus LB (43.4 hours) versus placebo (57.0 hours). This decreased duration was particularly marked in children with no antibiotic therapy before inclusion (31.1 hours): 42.9 hours for the L. acidophilus LB group versus 74.0 hours for the placebo group (p = 0.016).Conclusions:Addition of L. acidophilus LB to oral rehydration therapy was effective in the treatment of children with acute diarrhea by decreasing the duration of diarrhea.

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“…(12), but further invasion resulting in systemic infection and bacteremia appears to be uncommon (12). Translocation of campylobacters from the intestinal tract to the MLN has been specifically described in C3H (9,15) or athymic and euthymic BALB/c (20, 21) germfree mice. However, it is not known whether translocation is caused by specific determinants of virulence.…”

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confidence: 99%

Comparative translocation of enteropathogenic Campylobacter spp. and Escherichia coli from the intestinal tract of gnotobiotic mice

Youssef¹,

Corthier²,

Goossens³

et al. 1987

Infect Immun

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In C3H gnotobiotic mice, no significant difference was observed between the translocation of nine clinical isolates of enteropathogenic Campylobacter spp. and that of seven nonisogeneic Escherichia coli strains with or without various determinants of pathogenicity. In addition, there was no correlation found between the intensity of translocation of Campylobacter strains and the signs of invasiveness in the patients from whom the strains had been isolated.

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Modification par l'érythromycine et un extrait de Lactobacillus acidophilus de la colonisation de l'intestin et de la translocation de Campylobacter jejuni chez la souris axénique

Cited by 16 publications

References 10 publications

Health Benefits of Heat-Killed (Tyndallized) Probiotics: An Overview

Health Benefits of Heat-Killed (Tyndallized) Probiotics: An Overview

Clinical Evaluation of the Addition of Lyophilized, Heat‐Killed Lactobacillus acidophilus LB to Oral Rehydration Therapy in the Treatment of Acute Diarrhea in Children

Comparative translocation of enteropathogenic Campylobacter spp. and Escherichia coli from the intestinal tract of gnotobiotic mice

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