Modification of Xanthan Gum with Methyl Methacrylate and Investigation of Its Rheological Properties

Tulegenovna, Kusherova Parassat; Negim, El‐Sayed; Azzam, Khaldun M. Al; Bustam, Mohammad Azmi

doi:10.14716/ijtech.v13i2.4945

Cited by 3 publications

(4 citation statements)

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“…In addition, there was a significant absorption at 1739.12 cm −1 (-C=O group) and a new peak at 2950.41 cm −1 caused by the stretching band of the C-H groups (ether group). Furthermore, the COO-group was responsible for the peak from 1445.73 cm −1 [39].…”

Section: Synthesis Of Hydrogels and Ft-ir Datamentioning

confidence: 96%

New Methacrylated Biopolymer-Based Hydrogels as Localized Drug Delivery Systems in Skin Cancer Therapy

Luca

Nacu

Tanasache

et al. 2023

Gels

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The aim of the present work was to obtain drug-loaded hydrogels based on combinations of dextran, chitosan/gelatin/xanthan, and poly (acrylamide) as a sustained and controlled release vehicle of Doxorubicin, a drug used in skin cancer therapy that is associated with severe side effects. Hydrogels for use as 3D hydrophilic networks with good manipulation characteristics were produced using methacrylated biopolymer derivatives and the methacrylate group’s polymerization with synthetic monomers in the presence of a photo-initiator, under UV light stimulation (365 nm). Transformed infrared spectroscopy analysis (FT-IR) confirmed the hydrogels’ network structure (natural–synthetic composition and photocrosslinking), while scanning electron microscopy (SEM) analysis confirmed the microporous morphology. The hydrogels are swellable in simulated biological fluids and the material’s morphology regulates the swelling properties: the maximum swelling degree was obtained for dextran–chitosan-based hydrogels because of their higher porosity and pore distribution. The hydrogels are bioadhesive on a biological simulating membrane, and values for the force of detachment and work of adhesion are recommended for applications on skin tissue. The Doxorubicin was loaded into the hydrogels and the drug was released by diffusion for all the resulting hydrogels, with small contributions from the hydrogel networks’ relaxation. Doxorubicin-loaded hydrogels are efficient on keratinocytes tumor cells, the sustained released drug interrupting the cells’ division and inducing cell apoptosis; we recommend the obtained materials for the topical treatment of cutaneous squamous cell carcinoma.

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Section: Synthesis Of Hydrogels and Ft-ir Datamentioning

confidence: 96%

New Methacrylated Biopolymer-Based Hydrogels as Localized Drug Delivery Systems in Skin Cancer Therapy

Luca

Nacu

Tanasache

et al. 2023

Gels

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“…Multifunctional, safe for the environment, and healthy materials are preferred in every field of work. Xanthan gum, a biopolymer, is one of the safest and most multifunctional materials [1,2]. Xanthan gum is considered a polysaccharide polymer produced from biological origin that weighs approximately 2.65 × 106 Da [3].…”

Section: Introductionmentioning

confidence: 99%

“…Xanthan gum is considered a polysaccharide polymer produced from biological origin that weighs approximately 2.65 × 106 Da [3]. Because of its natural origin and safety (Figure 1), xanthan gum is a valuable product [2]. The bacteria Xanthomonas campestris makes this biopolymer [4,5].…”

Section: Introductionmentioning

confidence: 99%

“…Egyptian Journal of Chemistry http://ejchem.journals.ekb.eg/ Xanthan gum has an extensive range of applications, varying starting the food industry to extraction of oil. It is considered one of the valuable materials owing to its biodegradability nature, safety for the environment and organisms, and desired properties such as moisturizing, thickening, stabilizing, and wetting, as well as resistance to various environmental conditions such as pH and temperature [2,5,7].Apart from these benefits, xanthan gum has the following disadvantages: it is susceptible to degradation by bacteria, and the thermal transition temperature of xanthan gum saltfree solution is about 40°C when compared to a saltcontaining xanthan gum solution of concentration equal to 0.5% xanthan gum that dissolved in 1% NaCl solution, where the thermal transition occurs at significantly higher temperatures, typically exceeding 90°C. Gums' drawbacks can be improved by changing them including chemical derivatization as well as graft copolymerization.…”

Section: Introductionmentioning

confidence: 99%

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Modification of Xanthan Gum with Styrene and Investigation of its Rheological Properties

Kusherova,

Negim,

Aidarova

et al. 2023

Egypt. J. Chem.

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A "green" polymer made by bacteria, xanthan gum has several applications in both the food and drug industries. Because of its harmlessness, xanthan gum is frequently used in other fields after quality improvement through modification. This article describes the grafting process of xanthan gum with styrene and investigates the rheological properties of the modified (grafted) copolymer. For copolymerization, different ratios of xanthan and styrene compositions (XG: St -1:1.6, 1:5, and 1:8 w/w%) were used. The FTIR spectra of XG-g-St revealed an increase at 1120 cm -1 , indicating the formation of additional ether groups due to the St and XG interaction. The rheology properties were investigated at 30, 60, and 80°C. The shear stress of XG dropped from 30 to 80°C, with a maximum shear stress value of 8 Pa at 30°C and a minimum value of 5 Pa at 80°C.According to the findings, grafted with styrene xanthan gum has higher shear stress and better resistance to temperature in comparison with un-modified pure xanthan gum. Due to the grafting new side chains and bonds appear on polymer molecules which affect its viscoelasticity. These findings could be useful in a variety of fields, including oil recovery and construction.

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Assessment of a Novel Xanthan Gum-Based Composite for Oil Recovery Improvement at Reservoir Conditions; Assisted with Simulation and Economic Studies

Khattab,

Gawish,

Hamdy

et al. 2024

J Polym Environ

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Chemical flooding is a crucial technique in petroleum recovery. Although synthetic polyacrylamides are widely used, they suffer from hard reservoir conditions (high salinity, temperature, and pressure) and high costs. Current efforts focus on eco-friendly and affordable biopolymers like xanthan gum to overcome these issues. This study screens xanthan gum modification to improve its rheological properties and tolerance to high temperature, salinity, and shearing action by copolymerizing it with vinyl silane, vinyl monomers, and silica nanoparticles. The new composite was characterized using Fourier Transform Infrared Spectroscopy (FTIR), Thermal Gravimetric Analysis (TGA), Atomic Force Microscopy (AFM), and proton Nuclear Magnetic Resonance (NMR) tests. Its implementation was evaluated in polymer flooding at 2200 psi pressure, 135,000 ppm salinity, and 196°F temperature. Unlike previous studies that evaluated xanthan gum at 176 degrees °F, 1800 psi, and 30,000 ppm, without combining those three factors in one experiment. The rheological properties of native and composite xanthan were examined at reservoir conditions, as well as their viscoelastic properties (G‵ and G‶). Flooding runs used actual Bahariya formation cores at the lab scale. Simulation studies were conducted on a lab/field scale using the tNavigator simulator and economic feasibility to calculate the net present value. The most outcoming findings of this research comprise 1) investigating the impact of salinity, temperature, and pressure on the rheological properties of native and composite xanthan. 2) The composite xanthan exhibits more resistant criteria, as it recovered 27% residual oil versus 22% for native xanthan. 3) Modeling and simulation studies exhibit 48% oil recovery for composite versus 39% for native xanthan and 37% for water flooding. 4) Economically, using native and composite xanthan through enhanced oil recovery methods increased net

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Modification of Xanthan Gum with Methyl Methacrylate and Investigation of Its Rheological Properties

Cited by 3 publications

References 0 publications

New Methacrylated Biopolymer-Based Hydrogels as Localized Drug Delivery Systems in Skin Cancer Therapy

New Methacrylated Biopolymer-Based Hydrogels as Localized Drug Delivery Systems in Skin Cancer Therapy

Modification of Xanthan Gum with Styrene and Investigation of its Rheological Properties

Assessment of a Novel Xanthan Gum-Based Composite for Oil Recovery Improvement at Reservoir Conditions; Assisted with Simulation and Economic Studies

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