Modification of the effect of tamoxifen,<i>cis</i>‐platin, DTIC, and interferon‐α2b on human melanoma cells in culture by a mixture of vitamins

Prasad, Kedar N.; Hernandez, Christine; Edwards‐Prasad, Judith; Nelson, Joan M.; Borus, Todd; Robinson, William A.

doi:10.1080/01635589409514349

Cited by 75 publications

(48 citation statements)

References 18 publications

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“…It has been reported that a combination treatment of minocycline with BC or 13-cis-retinoic acid, along with cisplatin, can result in decreased cytotoxicity (40). Furthermore, a mixture of three or four vitamins containing BC showed the potential to enhance the growth-inhibitory effects of cisplatin on melanoma cells (41). In the present study, we demonstrated for the first time that BC can potentiate the cytotoxic effects of cisplatin against NB CSCs.…”

Section: Discussionmentioning

confidence: 49%

Effect of β-carotene on cancer cell stemness and differentiation in SK-N-BE(2)C neuroblastoma cells

Lee

Park²,

Kim³

2013

Oncology Reports

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Abstract. Neuroblastoma is a solid tumor often diagnosed in childhood. While there have been intense efforts to develop a treatment for neuroblastoma, current therapies remain unsuccessful due to high rate of resistance and metastasis. Most cancers originate from a subset of self-renewing cells, primarily cancer stem cells (CSCs), which establish a tumor through continuous self-renewal and differentiation. The successful elimination of CSCs is an important goal in the development of effective strategies to achieve complete remission for cancers. Although β-carotene has been associated with several anticancer mechanisms, the efficacy of β-carotene against CSCs remains unclear. In the present study, β-carotene was shown to reduce cell growth and induce neuronal cell differentiation, concomitant with a marked increase in the phosphorylation of extracellular signal-regulated kinases (ERK) (p42/p44). More importantly, β-carotene inhibited self-renewal characteristics of CSCs and decreased expression of several stem cell markers. Levels of mRNA and protein of Drosophila delta-like 1 homolog (Drosophila) (DLK1) were downregulated following treatment with β-carotene. In addition, knockdown of DLK1 by siRNA enhanced the inhibitory effect of β-carotene on colony formation of neuroblastoma cells. β-carotene also potentiated the effect of cisplatin on the self-renewal characteristics of CSCs in neuroblastoma, revealing that β-carotene has the capacity to resensitize cells to cisplatin cytotoxicity by directly targeting CSCs. In conclusion, β-carotene was shown to strongly increase the anticancer efficacy against neuroblastoma cancer stem-like cells. Moreover, these results suggest that the targeting of CSCs is a novel mechanism of β-carotene. Thus, β-carotene is a potential chemotherapeutic reagent for this cancer.

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Section: Discussionmentioning

confidence: 49%

Effect of β-carotene on cancer cell stemness and differentiation in SK-N-BE(2)C neuroblastoma cells

Lee

Park²,

Kim³

2013

Oncology Reports

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“…␣-TOS enhances the growth-inhibitory effect of several chemotherapeutic agents on cancer cells in culture. For instance, it augments the effects of doxorubicin (Adriamycin; Pfizer, New York, NY) on prostate carcinoma cells (Ripoll et al, 1986); the effects of cisplatin, tamoxifen, and decaprazine on melanoma cells (Prasad et al, 1994) and parotid acinar carcinoma cells (Prasad and Kumar, 1996); and the effects of doxorubicin on leukemia cells (Fariss et al, 1994).…”

Section: Synergism Of Ve Analogs With Other Inducers Of Apoptosismentioning

confidence: 99%

Vitamin E Analogs, a Novel Group of “Mitocans,” as Anticancer Agents: The Importance of Being Redox-Silent

Neužil¹,

Tomasetti²,

Zhao³

et al. 2007

Mol Pharmacol

126

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The search for a selective and efficient anticancer agent for treating all neoplastic disease has yet to deliver a universally suitable compound(s). The majority of established anticancer drugs either are nonselective or lose their efficacy because of the constant mutational changes of malignant cells. Until recently, a largely neglected target for potential anticancer agents was the mitochondrion, showing a considerable promise for future clinical applications. Vitamin E (VE) analogs, epitomized by ␣-tocopheryl succinate, belong to the group of "mitocans" (mitochondrially targeted anticancer drugs). They are selective for malignant cells, cause destabilization of their mitochondria, and suppress cancer in preclinical models. This review focuses on our current understanding of VE analogs in the context of their proapoptotic/anticancer efficacy and suggests that their effect on mitochondria may be amplified by modulation of alternative pathways operating in parallel. We show here that the analogs of VE that cause apoptosis (which translates into their anticancer efficacy) generally do not possess antioxidant (redox) activity and are prototypical of the mitocan group of anticancer compounds. Therefore, by analogy to Oscar Wilde's play The Importance of Being Earnest, we use the motto in the title "the importance of being redox-silent" to emphasize an essentially novel paradigm for cancer therapy, in which redoxsilence is a prerequisite property for most of the anticancer activities described in this communication.Despite advances in molecular medicine, the third millennium has borne witness to neoplastic disease becoming a major cause for mortality in developed countries. Moreover, fast-growing economies in countries like India and China are likely to be severely affected by cancer in a decade or so as a result of heavy industrialization. Certain types of cancer, such as malignant mesothelioma (MM), seem to remain beyond the realms of treatment. In many other cases, mutations arise in the tumors, seriously compromising the outcome of the therapy. For example, in breast cancer, in which a high frequency of overexpression of the tyrosine receptor kinase erbB2 occurs, this is often associated with resistance to chemotherapy (Xia et al., 2006). We are therefore in need of treatment modalities that would overcome these problems and that are efficient, selective, and readily available to all Article, publication date, and citation information can be found at http://molpharm.aspetjournals.org. doi:10.1124/mol.106.030122.ABBREVIATIONS: MM, malignant mesothelioma; BH, Bcl-2 homology; DHFR, dihydrofolate reductase; DR, death receptor; ERK, extracellular signal-regulated protein kinase; FLIP, Fas-associated death domain-like interleukin-1␤-converting enzyme-inhibitory protein; IAP, inhibitor of apoptosis protein; IB, inhibitory subunit of nuclear factor B; JNK, c-Jun N-terminal kinase; MAPK, mitogen-activated protein kinase; MPTP, mitochondrial permeability transition pore; MTX, methotrexate; NFB, nuclear factor-B; O...

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“…Our interest in antioxidants originated from the pre-clinical studies, which showed that pretreatment with antioxidants, such as vitamin C, beta carotene, alpha tocopheryol succinate and retinoic acid, significantly enhanced the growth inhibitory effects of cisplatin, dacarbazine, tamoxifen and several other anticancer agents on human melanoma and parotid carcinoma cells [6,7]. In a study with mice transplanted with adenocarcinoma of the breast, vitamin A (retinyl palmitate) or synthetic beta-carotene in combination with (x)-irradiation or cyclophosphamide increased the cure rate from 0% to over 90% [22].…”

Section: Discussionmentioning

confidence: 99%

Chemotherapy Alonevs.Chemotherapy Plus High Dose Multiple Antioxidants in Patients with Advanced Non Small Cell Lung Cancer

Pathak

Bhutani

Guleria

et al. 2005

Journal of the American College of Nutrition

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Modification of the effect of tamoxifen,cis‐platin, DTIC, and interferon‐α2b on human melanoma cells in culture by a mixture of vitamins

Cited by 75 publications

References 18 publications

Effect of β-carotene on cancer cell stemness and differentiation in SK-N-BE(2)C neuroblastoma cells

Effect of β-carotene on cancer cell stemness and differentiation in SK-N-BE(2)C neuroblastoma cells

Vitamin E Analogs, a Novel Group of “Mitocans,” as Anticancer Agents: The Importance of Being Redox-Silent

Chemotherapy Alonevs.Chemotherapy Plus High Dose Multiple Antioxidants in Patients with Advanced Non Small Cell Lung Cancer

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