1993
DOI: 10.1248/cpb.41.649
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Modification of the Amino Group of Guanosine by Methylglyoxal and Other .ALPHA.-Ketoaldehydes in the Presence of Hydrogen Peroxide.

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Cited by 27 publications
(18 citation statements)
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“…The mutagenicity of methylglyoxal was improved markedly in the presence of hydrogen peroxide. This was associated with the formation of N 2 -acetyldeoxyguanosine in DNA [26][27][28].…”
Section: Dna Glycation Mutagenesis and Ner (Nucleotide Excision Repair)mentioning
confidence: 99%
“…The mutagenicity of methylglyoxal was improved markedly in the presence of hydrogen peroxide. This was associated with the formation of N 2 -acetyldeoxyguanosine in DNA [26][27][28].…”
Section: Dna Glycation Mutagenesis and Ner (Nucleotide Excision Repair)mentioning
confidence: 99%
“…[1][2][3] Methylglyoxal is an endogenous metabolite. 4) Moreover, it was identified as a precursor of AGE [5][6][7] which accumulates in the plasma of uremic patients at a reported concentration of 1.53Ϯ0.25 mM. 8) This compound is known to react with the guanidino group in proteins 4,7,9,10) and it binds and reversibly modifies arginine residues.…”
mentioning
confidence: 99%
“…4) Moreover, it was identified as a precursor of AGE [5][6][7] which accumulates in the plasma of uremic patients at a reported concentration of 1.53Ϯ0.25 mM. 8) This compound is known to react with the guanidino group in proteins 4,7,9,10) and it binds and reversibly modifies arginine residues. [11][12][13] The reactions have been shown to occur even at physiological concentrations of methylglyoxal.…”
mentioning
confidence: 99%
“…117 Moulds Apesar de o metilglioxal existir sob tantas formas em água, a mais reativa é a ceto-aldeídica, segundo Nukaya e colaboradores (1993). 119 Esta é a forma produtora de ácido fórmico, ácido acético e diacetilo em meio aquoso tamponado com fosfato e H 2 O 2 diluído. Neste trabalho, detectou-se radical acetila e consequente formação de N-acetilguanosina, a qual poderia indicar uma atividade mutagênica do metilglioxal.…”
Section: Efeitos Citotóxicos E Tóxicos Do Metilglioxalunclassified