Modification of T-cell receptor Vβ repertoire in response to allergen stimulation in peanut allergy

Peanut-lupine antibody cross-reactivity is not associated to cross-allergenicity in peanut-sensitized mouse strains

“…Peanut is a major food allergen and the most common cause of fatal and near-fatal food-related anaphylaxis [1][2]. The allergy to peanut is characterized by more severe symptoms than other food allergies and by a high rate of symptoms on minimal contact [3,4].…”

The effect of specific immunotherapy on T‐cell receptor repertoire in patients with allergy to house‐dust mite

“…Several studies have demonstrated restricted TCR use in individuals with various allergic diseases and that these T cell subsets are allergen specific and can exhibit Th2 functional activities in terms of cytokine production (16–24). The TCR repertoire, however, is not static and can be further changed by antigen exposure in predisposed individuals (20,22,25,26).…”

“…Recent data have suggested that the diversity of the TCR V‐alpha or V‐beta usage of the antigen‐specific T cells appears to be limited in several allergic conditions as well (15–25).…”

“…demonstrated that specific TCR‐V subsets mediate the allergic response to certain antigens, and that transfer of specific TCR‐V subsets from sensitized mice to naive mice resulted in allergic sensitization in the naive recipients (15). Selective expansion of T cells expressing a particular TCR‐chain variable gene segment was demonstrated in lymphocytes of humans allergic to isocyanates (16), peanuts (17,18), pollens (19–21), cats (20), and house‐dust mite (HDM) (22–24).…”

Tumour suppressor genes do not regulate the cell cycle

“…In vitro stimulation of peripheral blood mononuclear cells with crude peanut extract resulted in stimulation of clonal/oligoclonal T cell responses, together with increased usage of TCRVB11 in peanut allergic individuals. 137 Analysis of clonality is a further means of characterising T cells in clinical hypersensitivity reactions; however, apparent specific T cell responses to antigen in some atopic individuals, characterised by oligoclonality of T cell populations at the affected site, do not always provide unique clonality profiles that could be used as diagnostic markers for these diseases.…”